Excerpts

Because the sample size was limited (although still among the largest of such studies in the field), we used raw p-value < 0.05 as threshold for nominally significant differential expression (supplementary Table 1 ).

There was a clear trend towards more advanced development (i.e. to the mid- and late brachiolaria stage at higher food densities (Supplementary Figs 1 and 2 ).

For leaf element ratios, we found that precipitation was the only factor retained in the C:P model and exhibited a marginally significant negative effect on this ratio (Table 1 ).

We also found that CHBs belonging to haplogroup D5 showed a trend towards having a very high VL and a lower frequency of VL <100 IU/mL (Fig. 3 ), which was considered as the cut-off for clinical HBV-DNA negativity.

The statistical significance of phenotype variables was assessed with the function anova.cca in vegan package, using 999 permutations to test for the marginal significance of each term after accounting for the effects of the others.

In many regions there was a clear trend for better agreement between rCPS estimates at higher injected doses.

Consistent with increased glycolysis with Age, citrate and isocitrate showed a trend towards increased abundance with Age in females (Fig.

The nitrate concentrations in the soil leachate were higher in May and mid-June than at the end of June and the end of July, and there was a decreasing trend of nitrate concentration over time.

In terms of clinical outcome, the 48 patients with EGFR mutation showed a trend towards longer DFS and a significantly longer OS, than those without EGFR mutation (Fig. 1A,B ; log-rank test, p = 0.069 and p = 0.015, respectively).

Second, an analysis of HR for bladder cancer stratified by obesity across smoking status strata showed a significant trend of increasing HR for bladder cancer across obesity and smoking status in multivariate-adjusted models.

The positive association between bladder cancer and BMI showed an increasing trend beyond the reference BMI.

This drug content is clearly significantly higher than conventional drug-loaded MSN having <1% wt. internal loading 16 , 35 , 42 – 45 .

4a are not able to show a clear trend, in Fig. 4b we reported the comparison between the number of cells undergoing the power-law behavior and the number of cells showing behaviors ascribable to active mechanics (oscillatory, saltatory or immediate retraction) as a function of the incubation time.

However, if saturated and unsaturated fatty acids were entered simultaneously into a multivariable model, each was a highly significant predictor (Combined model 1, Table 2 ).

All pairwise comparisons showed highly significant Fst-values (range = 0.081–0.096), confirming the significant discriminatory power of the random forest detected SNP subset.

The REACH-Pilot study comprised of 7 patients showed a trend towards improvements in 6-min walk distance and diuretic use 36 .

3d and the inset), the engineering stresses of grey matter after storage of 0 h, 1 h and 4 h are 1.06 ± 0.41 kPa, 0.93 ± 0.24 kPa and 0.69 ± 0.14 kPa (mean ± s.d.), respectively, indicating a decreasing trend in the engineering stress of grey matter due to the prolongation of storage duration.

H 2 values of growth rates (dynamic traits) showed an increasing trend until reaching maximal levels (>0.7) in the middle of the growing season (DAP 65 to 72 or DAP 72 to 87).

For the taxa that differed between HC and NAFLD, partial correlations between diagnosis status and abundance were highly significant after controlling for BMI or IR.

Additional pathways that showed a trend towards enrichment involved processes related to cell growth, proliferation, and apoptosis and included cell epidermal growth factor receptor (EGFR) signaling and the PI3 kinase and p53 pathways (p = 0.07–0.09).

Figure 3 shows that on an annual basis, less than 36% of the ice-free Greenland has experienced a significant trend and, if any, a cooling is observed during the last 15 years (<0.15 °C change per year).

In the 1990s, highly positive J / w values (more than +25 μmol kg −1 km −1 ) with an increasing trend were found for CW, and negative J / w values (less than −10 μmol kg −1 km −1 ) with a decreasing trend were found for DW, indicating increased (decreased) convective supply of DO to CW (DW).

The correlation coefficient between the Ct values of each allele was highly significant (Supplementary Figure 6 ).

From Arg0 to Arg3, there was an increasing trend of lipophilicity and molecular weight.

The incidence of OTSCC has shown an increasing trend in the population based cancer registry (PBCR) in India 9 , 10 .