Excerpts

More recently, a multitude of gene association and genome-wide association studies (GWAS) have identified MAPT as a highly significant genetic risk factor for sporadic Parkinson’s disease (PD), despite the lack of obvious tau tangles in the majority of PD patients 14 15 16 17 18 .

However, mRNA expression analysis of M1- and M2 macrophage markers in uteri from atERαKO mice revealed a statistical non-significant increase of the M1-marker Nos2, but more importantly a highly significant reduction of the M2-marker Arg1 by HFD ( Fig. 2G ).

Hepatocellular carcinoma (HCC) is highly prevalent especially in Asia and sub-Saharan Africa, and has an increasing trend in previously low incidence areas such as the US and Europe 1 .

officinale showed a trend towards the east and the north, which is consistent with previous genetic structure studies of D. officinale 50 51 .

As can be seen, with the increase in the inclination of the well, the force required to break the rock first follows a decreasing trend, and then it increases, which is reasonable considering the change in vertical stress from the pressure of the fluid column to the stress caused by the weight of the overburdened rock, but this increase in the model presented by Xin Ling is such that the reduction of the cutting force that is required to break the rock eventually occurs up to the well inclination of about 10° and then the increasing trend becomes so intense that the order of the numbers changes sharply.

109 of the 381 nodes within our network were overlapping with the PodNet components, which was highly significant (adjusted p-value, 2.1 × 10 18 ).

However, AR expression was not an independent predictor for either 5-year overall survival or disease-free survival, although it showed a trend ( Supplemental Table S2 ).

A marginally significant interaction for both of these comparisons AGO2 resulted from the slightly larger effect of siRNA treatment in Wolbachia infected cells compared to Wolbachia -free.

The p -values for the females-only sample for these SNPs were nominally significant but not significant when corrected for multiple testing (0.047 and 0.038, respectively).

It has been suggested that Precambrian cherts have much higher δ 30 Si values than Phanerozoic cherts do and that the former show an increasing trend from 3.5 to 0.85 Ga, reflecting a decrease in ocean temperatures.

Our recent study revealed a highly significant upregulation of SLC22A3 transcripts in PDAC tumors compared with non-neoplastic tissues 10 .

3a presents a clear trend that for a given resin formulation, the higher the curing temperature, the faster the decay of the sensor signal with respect to the processing time.

Kruskal-Wallis tests revealed highly significant differences among the three categories in their dN/dS, dN, dS, node degree, tissue specificity (τ), and multifunctionality ( Table 3 ).

In a band-conduction model, the resistivity is given by Arrhenius-type behavior: but the prefactor temperature dependency may be significant.

As can be seen, the current model’s trend of changes is such that when σ h < σ v , i.e., σ h = 80 MPa , increasing the well deviation angle up to 30° reduces the difference between the failure angle in the presented model and the model provided by Xin Ling, and, once again, this issue follows an increasing trend from 30° on.

From the above figure, it can be observed that when the first-floor area is 2000 m 2 , the annual energy consumption per unit area exhibits a decreasing trend followed by an increasing trend as the window-to-wall ratio increases.

The two nominally significant Reactome results (FDR ≤ 0.1) were Regulation of actin dynamics for phagocytic cup formation::2029482 and Fcgamma receptor (FCGR) dependent phagocytosis::2029480 .

It may be significant that the type of radiation used in this study, moderate energy X-rays, is quite similar to the type of low energy, and largely unfiltered, fluoroscopy X-rays used here 20 , albeit for therapeutic rather than diagnostic purposes, and contrasts with the rather higher energy radiation to which nuclear

The Canadian study also reported an increasing trend for IHD mortality with dose in the entire dose range with an inverse risk modification by dose fractionation using 10-year lag, the evidence for which became much weaker when dose was restricted to less than 0.5 Gy, or when 5-year lag was used 18 .

This contrasts with analysis over the full dose range, when a negative trend in excess mortality risk with dose was observed for all circulatory disease, IHD, all deaths, and all deaths excluding circulatory disease.

However, we found only one highly significant pathway for the cerebellum (Neuroactive ligand-receptor interaction, p.adj. = 5.26 × 10 –9 ), which was not shared with any other tissue and is therefore not part of the heatmap (Fig. 6 D).

All ANOVA models were highly significant.

A clear trend to higher current densities with higher Cr content is observed.

Every 1-unit increase of score of pattern II was significantly associated with an increased risk of rhinitis, though the effect in females was marginally significant.

Linear trends indicate that 76% of the meteorological stations show a positive trend in annual precipitation during 1985–2010, and notably, five of them are statistically significant at the 90% confidence level (see Supplementary Table S1 , Fig.