Excerpts

The three genome-wide significant results were then investigated further by examining their association with coronary artery disease (CAD) using a large sample (n = 5,765 CAD; n = 7,624 controls) with two linked SNPs, located in the ELF5 gene region, nominally significant.

There appears to be a clear trend: the more weight there is assigned to exploratory steps, the easier it appears to decide on the node groupings.

Although no clear biological meaning can be attached to these canonical variables, which are linear combinations of features used in each section where the coefficients are data-dependent, this methodology reveals the existence of large and highly significant differences between the cells.

A decreasing trend in the feedstock conversion was observed from 93.8 to 50.6% when the water content in ethanol increased from 5 to 80 wt.% under the same reaction time of 5 hours.

This risk was highly significant, particularly in non-obese men (461%), but not in their obese counterparts or in women.

Expression of 361 genes displayed highly significant differences in their level of expression between never and current smokers.

Finally, aquatic vegetation in Eastern Lake Taihu was inhibited and showed a decreasing trend in our study period due to increased eutrophication and a deteriorated underwater light environment.

Our findings indicate that NOS1 may be significant in the pathophysiology of human ischemic heart disease with a preservative role in maintaining myocardial homeostasis. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2015 Nov 12; Accepted 2016 Mar 18; Collection date 2016.

Jackal survival also appeared to show an increasing trend over the years (‘Time’ factor in Table 4 ), and this factor was included here for controlling this source of variation.

ANOVA showed significant contributions by season, salinity zone, and year to the variances of f_chl-a taxa for several major taxonomic groups, with highly significant (p ≪ 0.001) effects of climatic conditions on all but one group ( Table 2 ).

73290, showed extremely significant differences in SNPP in all four investigated environments.

In 2007, van Gool and colleagues found that after 3-year rhGH plus GnRHa combined treatment, short adolescent boys showed a trend towards decreased BMD 41 .

In terms of the medium- and large-split contrast, the accuracy rates were virtually the same, although the difference in reaction time was highly significant.

Our results indicate an increasing trend with age in the production of HLA-DR by FP-MSCs after exposure to IFN-γ.

In recent years, there is also an increasing trend to apply proteomics in zebrafish for developmental analyses, disease studies and assessments of chemical toxicity.

Both changes in the expression level were highly significant ( p -values 2.5 × 10 −6 and 4.9 × 10 −6 ).

The PMCH gene is not detected significant in the ordinary regression (P-value: 0.429), but is detected highly significant in the robust regression (0.022).

The increasing trend of summer and winter precipitation over the Himalaya is associated with an increasing trend in precipitation extremes connected to the changing pattern of the summer monsoons 20 , 24 , 25 , 26 , 27 , and an enhancement in the strength and frequency of winter westerly disturbances 18 , 28 , 29 , 30 , 31 (extratropical storms driven by the Westerlies, that bring sudden winter rain and snow to the northwestern parts of the Indian subcontinent), respectively.

The activation profile of the different OSNs revealed a highly significant activation in response to food odor compared to controls in ciliated and microvillous OSNs (cOSNs, mOSNs) ( Fig. 3a,b ).

The calculated R ′ showed a decreasing trend with depth for both Fe and P, reflecting that the capacity of the sediment solids to sustain the pore water Fe or P became weaker with depth.

There was an increasing trend with depth down to the sediment bottom at Sites 3, 7, 8, 10, 11, 14, 15 and 16 for both Fe and P, and at Site 5 for Fe.

And a clear trend of antifouling capability is revealed as GO-P-S membrane >P membrane >GO-P membrane.

A clear trend which was already found and discussed by Miyake et al. 7 is the strong increase in K 1 when going from 1–12 to 1–12-X phases.

2 ), performed with the REDFIT method, reveals a significant periodicity at 208 years and marginally significant periodicities at 83, 31, 18–16, 11, 9 and 7–3 years ( Fig. 2 , Supplementary Fig.

Nevertheless, the median lines and the Inter-Quartile Ranges (IQRs) clearly suggest a decreasing trend with a high confidence.