Barely Significant

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A higher P -value threshold of 0.25 for PST was chosen because, in our dataset, the number of immune signatures with P -values below 0.05 was limited (Supplementary Table S1 ), and raising the threshold allowed for the inclusion of potentially informative immune signatures that showed a trend toward association with survival, reflecting the more subtle role of immune features in these tumors.
In an institution-clustered GEE model with robust standard errors, point estimates were directionally consistent with the primary model; stenosis at C3/4 remained significant (OR 2.13, 95% CI 1.38–3.29), and the association for posterior decompression and fusion was attenuated to borderline significance (OR 2.71, 95% CI 0.99–7.44) (Supplementary Table S2).
Based on tree-ring-based reconstructions of June–August VPD, 43) also found an increasing trend in summer VPD during recent centuries in Central Europe and the Mediterranean region over the past four centuries, supporting the signal of intensifying atmospheric drought across the World.