Excerpts

We observed a significant trend for the medians (Cuzick test for medians trend, p < 0.05) of the relative expression of miR-143-3p (p = 0.029), miR-143-5p (p = 0.020) and miR-30b-5p (p = 0.033) with increasing severity of the lesions (Fig. 3 a).

At 14 dpi, dynamics shifted and WT mice showed a statistical trend towards an increase of TNF-α mRNA expression compared to CLEC12A −/− mice ( p = 0.05, Fig. 4 A), likely related to prolonged virus infection in WT mice.

Similarly, AST levels were higher in the nanocurcumin group (38.44 ± 23.38 U/L) compared to the placebo group (27.21 ± 10.07 U/L), with a P -value approaching significance ( P = 0.05).

Out of 19,927 genes included in analysis, 613 were nominally significant between randomization groups (Fig. 4 A; p < 0.05), of which 313 were up-regulated and 300 down-regulated in the placebo-smokers versus the vitamin C-smokers.

If the result of the MR analysis was nominally significant ( P < 0.05), we inferred that there might be a causal relationship between the gut microbiota and the outcome 26 .

In addition, with the increase of Fe-BC application amount, soil organic matter content showed an increasing trend, and there were notable variations between the groups that received different treatments ( P < 0.05).

CC), the combined frequency of heterozygous and homozygous mutant genotypes (CG + GG) was 48.39% in cases and 40.32% in controls, but this difference did not reach statistical significance ( p = 0.05; OR = 1.39, 95% CI = 1.01 to 1.91).

During the summer, the average ET a was 329.61 mm, with an increasing trend of 0.43 mm/year ( p < 0.05).

Associations between biomarker levels and post-interventional clinical and radiological variables Patients with post-interventional ASPECTS values < 8 (n = 21) showed higher serum levels of β-syn (p = 0.0014) and GFAP (p = 0.008) compared to patients with ASPECTS ≥ 8 (n = 9), whereas the increase of NfL was of borderline significance (p = 0.05) (Supplementary Fig. 2 ).

Although limited by sample size, the P value for LMNA did not reach statistical significance ( P < 0.05), whereas CEBPB exhibited a significant response (Fig. 8 K, L).

The mean concentrations of K, Zn, and Cr were highly significant ( P < 0.05) amongst the sampled fish, notably showing elevated levels in fish sampled from the Patuakhali area.

Among them, 59 immunophenotypes exhibited a nominally significant causal association with TMD (IVW, P < 0.05).

In general, the Tukey-test (Table S1a–f) showed a significant effect of interspecific competition ( p < 0.001) in all cases except for the bur weight in 2023, whereas for the intraspecific competition it was highly significant ( p < 0.001) for the plant biomass in both years and for bur number in 2022, significant ( p < 0.01) for the bur number and only marginally significant ( p < 0.05) for the bur weight in 2022 (Fig. 3 ).

The control and DSEO -3 groups showed a decreasing trend, with peaks on days 1, 6, and 9 for the control and day 9 for the DSEO -3 group ( P < 0.05).

Negative sensory descriptors such as musty or earthy odor and taste were minimally perceived and did not reach statistical significance (p < 0.05).

Moreover, the p -value for rs359240 in the PC-UKB sample was nominally significant ( p < 0.05).

Sex-specific differences in trends were nominally significant (p < 0.05) in six countries—Benin, Kuwait, Argentina, Saint Vincent and the Grenadines, Thailand, and Guyana—but only two (Saint Vincent and the Grenadines and Thailand) remained statistically significant after Bonferroni correction.

With time, the expression levels of osteogenic factors displayed an increasing trend ( P < 0.05).

ANOVA summary typical of experimental Plackett–Burman tests indicated that the model was highly significant, due to the low probability value (p value ~ 0.05).

For the DrugBank dataset, the PS3N model showed highly significant improvements in Precision and Recall (both with p < 0.05), confirming the model’s strength in accurately classifying interactions.

Moreover, the presence of chocolate ingredient had a borderline significant effect on AFB1 (p = 0.05) and a significant effect on OTA (p = 0.002), with higher percentages observed in SKUs containing chocolate.

Primary outcome At Week 7, LM/S did not demonstrate significant improvement compared to CAU in depressive symptoms (adjusted mean difference = − 1.21, p =.80, d = 0.24), while the PLM showed a marginally significant reduction relative to CAU (adjusted mean difference = − 3.96, p =.05, d = 0.78).

Pooled analysis Metabolites with nominally significant differences (p<0.05) and trends (0.05<p<0.10) between screening and Year 3 within the FP and AP groups Metabolites that were nominally different are reported in Table 2 with circulating concentrations reported in Table S1.

In the main positive dataset, amino acid residues Ala, Phe, Leu, Pro, and Tyr are highly significant (adjusted p-value < 0.05), while in the main negative dataset, the residues Cys, Asp and Thr are significant.

Infantis showed a trend characterized by a high APC from 2008–2010 (p < 0.05) followed by a lower APC from 2010–2018 (p > 0.05) (see Suppl.