Excerpts

Within the transfected FH-MC-LDLR population, the suppression elicited by free sterols was extremely significant when compared to Lovastatin ( p = 0.00004) and significant with regards to the ethanol control ( p = 0.02).

While sample size used for this analysis is fairly small (due to the exclusion of netted and orange or green rind accessions), the strongest genome-wide effect that we found for this trait, on chromosome 10, was still marginally significant at FDR30% (P = 4 × 10 −5 , MLM).

Another correlated SNP in the same region (rs269101, r 2 = 0.42 in 1000 genomes phase3 Finnish individuals) showed a trend toward association in our GWAS ( p = 4.2 × 10 −5 ) and in the replicate ( p = 0.054), further supporting the result.

We also re-ran the model, including average mean diffusion in the TBSS-derived skeleton as an additional predictor, which had minor effects on the results, reducing the p-value for atrophy slightly (0.031), while retrieval activity was still highly significant ( p = 4.46 e −5 ) and R 2 (adjusted) = 0.237.

For the plastic bag-samples, a highly significant difference between the reference material and the two obtained samples (plastic bag-metal and plastic bag-no metal) was observed (1-way ANOVA, F = 12.9, p = 4.5 × 10 −5 ), while the means of the two plastic samples showed no significant difference (post-ANOVA Tukey-test, p adjusted = 0.11).

The P-value is highly significant when corrected for multiplicity (207 sites, Bonferroni corrected P-value = 4.6e-5).

There were two SNPs in the serum IgG analysis, one SNP in the total protein analysis, four SNPs in the globulin analysis, four SNPs in the ZST analysis, one SNP in the specific gravity analysis and three SNPs in the crude illness analysis, which approached significance ( P < 5 × 10 −5 ) (Table 3 ).

The difference between the survival curves for of the high and low risk phenotypes is highly significant (p < 0.00005).

Across the significant surprise effects, this yielded a highly significant positive correlation (r = 0.75, p < 0.00005; Fig. 2C ).

Also, all the other measures showed clearly significant results resembling the associations with the ACarPA status (all p < 5.7 × 10 –5 , Supplementary Table S3 ).

Predictive value of biomarkers and clinical variables on cumulative ICU survival ICU survival at 28-day was associated with highly significant values of IL-1RA serum levels ( P = 0.00006, HR 1.31, 95% CI 1.15–1.50) and SOFA score ( P = 0.001, HR 1.18, 95% CI 1.07–1.30) in septic patients.

The difference for DCH prevalence was statistically extremely significant (p-value = 0.00006, OR = 4.04005, CI95% = [1.96601; 8.30211]) when compared animals from collection A and collection B (Fig. 1A ).

Three such modules (red, ivory, and light yellow) showed highly significant correlation with the MeJA treatment (Pearson r = 0.75—0.88; p = 6.04E−05–2.03E−09; Fig. 6 A; Supplementary Table S7 ).

An extremely significant increase was detected throughout the day’s 14 ( P = 0.00007, 0.0001, and 0.0008) and day’s 28 ( P = 0.000, 0.000, and 0.0001) of period studied in all present treated groups (Pro 4, Pro 7 and mixture of Pro 4 and Pro 7 strains respectively) compared to untreated group.

Abundance estimates provided by RepeatMasker showed highly significant positive correlation with those yielded by RepeatExplorer in both the Southern (Spearman r s = 0.84, N = 15, P = 0.000074) and Northern (r s = 0.97, N = 17, P < 0.000001) lineages.

Only one of the 1089 ligand/receptor screens for these dRy variants was positive, in contrast to 102 of 8815 screens for sequences having this Arginine, which is a greater than 12-fold enrichment and highly significant (hypergeometric p-value = 8 × 10 −5 ; Table S4 ).

The dissimilarity metrics, measured separately with Bray-Curtis, Jaccard, and Jensen-Shannon (JSD) indices with 10,000 permutations, were all highly significant (PERMANOVA, p = 9.999e-05), representative of the centroids being different between the two groups.

In individual comparisons, the correlation value ranged from 0.85 to 0.98 and was highly significant in all the cases (P-value < 0.0001).

Importantly, multivariable Cox analysis demonstrated that CCNF remained a highly significant predictor of OS independently of histologic grade and TNM stage (HR 2.86, 95% CI 2.02–4.06, p < 0.0001; Table 4 ).

The difference was highly significant (t-test, t = 19.931, df = 18, p < 0.0001), suggesting that the FTS experiences stronger selection than the HTS.

Linear regression analysis showed a highly significant correlation between hemispheric loss and hippocampal area loss (R2 = 0.855, p < 0.0001), with hippocampal loss tending to be greater (B = 1.209) than hemispheric area loss.

In the absence of BPs, vWF expression by the endothelial growth media stimulated pMSCs showed an increasing trend over the experimental period with a significant 4-fold up-regulation (p < 0.0001) in expression at the end of ten days.

All four models were highly significant ( p < 0.0001) with non-significant lack-of-fit tests ( p > 0.05), indicating adequate model fit.

Statistical analysis revealed highly significant linear and quadratic effects for all metrics ( P = 0.0001, indicating a complex relationship between selenium dose and growth, with potential for an optimal selenium level.

Moreover, the Wilcoxon rank-sum test reveals that the differences in microbial diversity between these two ecosystems were extremely significant ( p -value < 0.0001).