Barely Significant

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Population structure in the PLCO prostate cancer study We applied the PCA using the set of 12,898 structure inference SNPs in the original nested case-control study of prostate cancer (PLCOca-PLCOco) and found that the top 4 PCs are strongly significant with P-values less than 10 −4 based on the Tracy Widom test, while the 5 th is borderline significant ( Table 1 ).
We observed small values of D (mean 0.24), indicating that the deviation of each subsample from the uniform distribution is small, and moderate values of p (mean 0.2, with 32% of the p values<0.05), suggesting that this deviation from uniformity is at best only marginally significant ( Figure 4A ).
highly significantqualifiedgold
While the data show a clear and highly significant association of the biomarkers and models with stroke, it is evident that the results require further refinement and evaluation in larger prospective studies where we can fully assess the potential role in clinical practice.