Accordingly, although there were overlapping CIs for hazard rate ratios, the difference in risk of CV death between ACEI-treated patients with ischemic versus non-ischemic CHF, showed a trend for increased risk of CV death with increasing score A in patients with ischemic CHF (P = 0.332 [ Fig 4 ]).
These associations were non-linear, but with a significant trend in odds of diabetes with increasing bilirubin among men (men: p-trend = 0.003, women: p = 0.34).
bevacizumab group, pemetrexed did not exhibit an obvious change in PFS (HR = 0.96, p = 0.752; I 2 = 35.8%, p = 0.212) or OS (HR = 0.98, p = 0.744, I 2 = 0.0%) but exhibited a slight trend to reduce grade 3–4 AEs (HR = 0.79, p = 0.343, I 2 = 65.7, p = 0.088).
However,decreased BMI(median OS 8.9 vs 9.3 months; HR 1.218, 95% CI 0.936–1.585; P = 0.142; Fig 4B ) showed a trend to worse prognosisand BMI at diagnosis did not influence on OS ( P = 0.357).
However, when the same comparison was performed after separating major (intracranial, gastrointestinal or any other type of bleedings requiring blood transfusion) from minor bleedings, we found a significantly lower incidence in minor bleedings in favor of the NOACs (RR = 0.69 95% CI 0.56–0.85; p = 0.0003) ( Fig 5A ), while no statistically significant difference in the incidence of major bleedings was evident, despite a clear trend in favor of the NOACs-treated arm (RR = 0.82 95% CI 0.53–1.25; p = 0.36) ( Fig 6 ).
Minimal regulation of pleiotropic immunomodulatory cytokines Regarding the pleiotropic cytokines, a slight trend towards an IL-13 (control: 3.12±0.19 pg/ml, DR: 2.85±0.14 pg/ml; p = 0.36; Fig 2C ) down-regulation was observed in DR samples.
After controlling for other variables, there were no differences when comparing odds of ideation among females to males in the depression cohorts (OR = 2.3, 95% CI: 0.75–6.98; p = 0.14), nor was there a significant trend among age categories (p = 0.37).
When looking at the linear frequency domain, for LF/HF, only a slight trend with small effect size towards a decreasing ratio value after yoga intervention could be identified (p = 0.383, g* = -0.263).
patagonica did not differ between the two locations (La Hormiga and El Hormigón; two-way ANOVA comparing abundance of open spaces associated to coral colonies among locations, main effect location: F 1,3,1501 = 0.0152, p = 0.9093) or over time, despite showing an increasing trend (2005, 2006, 2007, 2010; main effect time: F 3,- = 1.4271, p = 0.3886).
There was no evidence of a decreasing trend in catch at 10 m (estimate = 0.085, ± SE = 0.098, p = 0.39) or 25 m (estimate = 0.096, ± SE = 0.082, p = 0.24).
This lower performance in ALT in the immediate test was due to a (marginally significant) performance drop of performance in ALT from the last 5 trials at the end of training (at which time there was no difference (two tailed t -test, P = 0.40) between ALT and LONG-ITI) to the first immediate test ( P = 0.05) Dissociation of time and interference-induced between-trial forgetting Between-trial forgetting due to either time or interferences or both during training was assessed by taking the difference in performance between conditions (see Methods ).
When edaravone was added to tPA-treatment at 1 h (E + tPA 1 h), the mortality rate was similar to those received tPA alone (27.7%), but the infarct size showed a trend of further reduction (15.5%, p = 0.40 compared to the tPA-treatment alone).
However, young women had a reduction in their experiences of physical IPV at the hands of their husbands in the past year (10% - 4.4%, β = -0.08, p-value = 0.077) also approaching conventional statistical significance, while older women reported a slight increase in experiences of physical IPV (6% - 9.6%, β = 0.03, p-value = 0.404).
Although, there is an increasing trend, no significant correlation (Spearman’s rho = 0.108, p = .410) is found between expression level and tumor stages.
For the context test, while we did not find any main effects there was a strong trend for an effect of the demonstrator’s sex ( Fig 2B ; two-way ANOVA, OBSERVER’S SEX: F 1,27 = 0.6907, p = 0.4132; DEMONSTRATOR’S SEX: F 1,27 = 3.914, p = 0.0582; OBSERVER’S SEX x DEMONSTRATOR’S SEX: F 1,27 = 3.600, p = 0.0685; N = 7–8 per group).
However, at 15 U/kg/wk doses, the Vela-injected mice showed a trend toward greater (∼66%) reductions of GC levels compared to ∼55% in Imig injected mice (p = 0.42).
Although there was a decreasing trend of mean water content from the W1 to W4 treatment, no significant difference was found ( P = 0.43).
Analyses revealed a small but significant overall effect of distributing practice on acquisition performance ( η 2 = .127, p <.001) and a marginally significant effect on retention performance ( η 2 = .108, p = 0.44).
A weak trend of sBAT-R 2 * normalization was observed after reheating (0.15±0.70 s -1 , P = 0.441 compared to the Baseline MRI and -0.50±1.33 s -1 , P = 0.173 compared to the Cold MRI ) ( Table 1 , Fig 3B ) whereas SAT-R 2 * remained increased (0.47±0.55 s -1 , P = 0.028 compared to the Baseline MRI and 0.07±0.49 s -1 , P = 0.767 compared to the Cold MRI ) ( Table 1 , Fig 3B ).
The intermediate risk group showed a trend to reduction in mortality (17.8% to 10.3%, aHR 0.82, p = 0.46) which was not observed in the low risk group (7.8% to 9.2%, aHR 1.4, p = 0.31).
Among the total study population, RICI showed a decreasing trend (y = –0.6571x + 89.571, p = 0.462), whereas UAO and Tumor showed an increasing trend (y = 2.2044x + 23.824, p = 0.091 and y = 1.4769x – 0.9341, p = 0.001, respectively).
Control mice ( Fig 3A ) showed a trend to interact more with the novel object (not significant, p = 0.466) and Tg2576 mice showed a trend to interact less with the novel object (not significant, p = 0.257).
The same trend was not observed for bacteria – inoculation treatment only had a weakly significant effect on the community composition of bacteria (multivariate PERMANOVA, F 3,52 = 0.100, p = 0.47, R 2 = 0.054) ( Fig 6B ).
There was no statistically detectable relationship between time-attacking and egg mass ( P >0.40); however, the data followed a similar pattern, no relationship in 2009 and a negative trend in 2010 ( Figure 2 ), (2009: P >0.50; 2010: R 2 = 0.23, P = 0.1179).
Results In a Spearman rank-order correlation hemi-matrix, of 55 paired combinations of the 11 biomarkers, 28 (51%) were significantly correlated among each other (p≤ 0.05), with the strongest association being retinol and tocopherols (r = 0.697, p<0.001), and 4 associations (9%) showed a trend (p> 0.5 to ≤ 0.10).