Excerpts

There was only a marginally significant difference ( P = 0.04) with higher incidence of TGCTs in CP-treated 129S5 mice than in CP-treated 129S1/SvImJ mice.

Phyla-level phylogenetic binning of 16S rRNA data revealed a nominally significant correlation between the Bacteroidetes:Firmicutes ratio and age- and sex- adjusted BMI (r = 0.116; p = 0.04), but no significant correlation with metabolic syndrome traits [fasting glucose (r = 0.075; p = 0.19), systolic or diastolic blood pressure (r = 0.016; p = 0.78 and (r = 0.043; p = 0.45), respectively), fasting triglycerides (r = 0.078; p = 0.17), HDL-cholesterol (r = −0.052; p = 0.36); all adjusted for age and sex) Results from unweighted UniFrac analysis [16] also did not distinguish among the subjects based on BMI ( Figure S5 ).

A borderline significance (RR 0.29, 95% CI: 0.09–0.95; p = 0.04) in favour of HVGIC was established after the period of 60 months.

Moreover, when considering the mean percent of contributing pairs as a threshold to separate good from poor years, more pairs contributed to the production of young during good years (49.82±1.98%) than poor years (40.84±3.59%), but the difference between the number of pairs was only marginally significant ( t = −4.03, p = 0.04).

For both the 80°C and 90°C burns there was a strong trend of increasing perfusion with time post-burn, with B/N ratios at day 7 significantly higher than at 24hrs and day 3 (p ≤ 0.04, p ≤ 0.03). 4 Discussion An effective burn model must have reliable and consistent tissue injury.

There was a small higher risk of 30 day mortality, but only at a borderline level of statistical significance (OR 1.07, 95% CI 1.00–1.14, p = 0.040).

For the right intra-parietal sulcus, a post-hoc pairwise comparison of the information values across subjects reached marginal significance with respect to the right intra-parietal (p = 0.04), right frontal eye field (p = 0.04) and superior frontal gyrus (p = 0.06).

With the no-schooling group as the baseline, the subjects with a “primary education” were positively associated with total cost at a borderline significance level (estimated coefficient = 1579.521, p -value = 0.040).

There were no associations in scleral thickness between the anterior segment and posterior segment (except of a modestly significant ( P = 0.04) association between limbal scleral thickness peripapillary scleral thickness).

Although there was no significant relationship between exercise intervention and mtDNA-CN change (P = 0.29), there was a nominally significant association between mtDNA-CN and metabolic syndrome (P = 0.04), which has been seen in previous literature.

Further stratified analyses between boys and girls showed that nominally significant genetic association with BMI z-scores was found in girls but not in boys ( Fig 1A ; in girls: AG vs AA coefficient = 0.6, p = 0.04, 95% CI: 0.02–1.18; GG vs AA coefficient = 1.33, p = 0.02, 95% CI: 0.17–2.49).

PennCNV showed a trend at the PARK2 locus (p = 0.04; Figure S1A ) that was not significant after correcting for multiple tests.

We found a highly significant strain effect ( F 1, 56 = 102.07, p = 3.2×10 −14 , η p 2 = 0.646), no significant effect of week studied ( F 3, 56 = 1.72, p = 0.17, η p 2 = 0.084), and a modestly significant interaction effect ( F 3, 56 = 2.96, p = 0.040, η p 2 = 0.137) using a two-way ANOVA on transformed in-cage activity data.

The expiration/inspiration ratio showed a marginally significant benefit (WMD = 0.05, 95%CI 0.00 to 0.09, P = 0.040).

This difference was significant for the Runner group [t(9) = -3.105, p = 0.012] but barely failed to reach significance for the Team sports group [t(9) = -2.392, p = 0.040 uncorrected, with an alpha adjusted to 0.025].

Relationships between cooperativity and specialization versus network node and edge counts were either statistically significant or marginally significant (p = 0.04 and 0.06, 0.07 and 0.11, respectively) ( Fig. 4C, 4D ).

The results suggest no statistically significant differences after up to 48 months and borderline significant differences in favour of HVGIC sealants after 60 months (RR 0.29; 95% CI: 0.09–0.95; p = 0.04 / RD -0.07; 95% CI: -0.14, -0.01).

Tumors having both alterations, while present in a small subpopulation (n = 6), had worse prognosis of borderline significance ( P = 0.04, Fig. 7 ).

Additionally, a significant trend was observed for the end of the nesting season, which has been delayed by an average of 1.0 days.yr -1 (p = 0.04, R2 = 0.19).

Hypsodonty shows no relationship with time in either clade ( Table S4 , Dataset S2 ), but ANCOVA shows the observed difference in the intercepts is marginally significant ( p = 0.04, Figure S5 , Table S3 ), meaning that Karnimata species have higher tooth crowns than the “ Progonomys clade”.

Sighted controls’ error when the sound ended 25 cm to the right was only marginally significant (one sample, 2-tailed t-tests with Bonferroni correction for multiple comparison, t (7) = 2.44, p = 0.04).

Although the enhancement effect of BSA in the phospho-T286-induced CaMKII binding failed to reach significance in the ANOVA model, it was significant by t-test, [t(5) = −2.2813, p = 0.04] ( Fig. 4 ).

Further none of the secondary variables did show any significant differences from placebo apart from MMTT AUC C-peptide 0-4h and GGI AUC Glucose0-1h which showed mechanistically contradictory borderline significant effects of p = 0.04 and 0.045 respectively (Fig F in S1 File and Table 2 ).

The groups were not significantly different overall, but the pattern of increasing activity in controls versus a decline in tumour mice was maintained, but was only marginally significant (‘Group×Time’; F(14,308) = 2.3, p = 0.04).

Although there were statistically marginally significant differences observed with respect to week 16 cholesterol and non HDL cholesterol (p = 0.04 and p = 0.03, not corrected for multiple comparisons), within each arm there were no significant changes from baseline.