Excerpts

Moreover, a fairly significant correlation has been found between oxidative DNA damage in the human trabecular meshwork (HTM) and increased intraocular pressure and visual field defects in glaucoma patients [ 37 ].

Here we have shown improved episodic memory performance in delayed word recognition and marginally significant improved visuo-spatial Corsi Block performance at 3, but not 6, months following intervention alongside a lowering of systolic blood pressure at both time points.

Though our visuo-spatial findings here did not quite reach significance, beneficial effects of blueberry supplementation on visuo-spatial memory in aging rats is well documented (for example [ 9 , 25 ]), and polyphenol-rich chronic interventions with procyanidins have previously shown positive visuo-spatial benefits for older adults [ 26 , 27 ].

Additionally, the number of total newborns and live newborns showed an increasing trend in the daidzein group.

There was a decreasing trend in both SIRT1 and PPAR-α expression levels in the IDH2 FRU mice compared to the other groups, which is also in agreement with phenotypes (i.e., Figure 1 E).

We did not find a positive trend of WMA after 6 months of age calling into question the validity of the skim milk studies.

Models for Māori and non-Māori showed a trend towards increasing serum vitamin B 12 concentration with an increase in vitamin B 12 intake increased but was not statistically significant. 3.7.

They showed that the PNPLA3 I148M genetic variant was strongly associated with increased liver fat content, and that the association remained highly significant after adjusting for BMI, diabetes, ethanol intake, and global and local ancestry.

SDNN did not change after supplementation with marine n -3 PUFA, but a significant effect on SDNNi and a borderline significant increase in rMSSD and HF was observed, indicating an improvement in vagal modulation.

A highly significant ( p -level of 0.01) relationship with an R 2 of 0.59 was observed between the enzymatically measured fructan hydrolysis in wheat flour and the remaining fructan levels in the model system after fermentation for 72 h.

Also, the intake of certain types of fiber that may be significant predictors in the pathogenesis of cholelithiasis has been described [ 13 , 14 ].

When infants were excluded, there was a significant trend toward lower DS use with increasing age.

GZMA, GZMH, GZMM, GNLY and PTPRC showed no association between expression levels and time post-partum ( Table S4, Figure S2 ) whereas PRF1 had a borderline significant decrease ( p -value 0.068) ( Table S4 ).

Our data, showing a highly significant negative association between s-leptin levels at 5 mo and weight gain from 5 to 9 mo, could be a result of decreased leptin resistance when other foods were introduced, with s-leptin then having an anorexigenic effect.

[ 30 ], the mean difference, limit of agreement (LoA), as well as Bland-Altman index were calculated, after a log transformation applied due to non-parametric distribution, as commonly applied [ 34 ], while a Bland-Altman index of 5% was interpreted as a positive validation [ 35 ] and a Bland-Altman index of 10% was interpreted as a borderline significant [ 36 ], which was assumed a priori [ 37 ], (2) analysis of cross-classification in quartiles: the share of correctly classified and grossly misclassified (classified to the opposite quartiles) individuals were indicated, while at least 50% of correctly classified and, at the same time, less than 10% of grossly misclassified individuals was interpreted as a positive validation [ 38 ]; (3) analysis of the weighted κ statistic: as a method recommended by Cade et al.

Although, as in all correlational studies in general, it is hard to postulate a certain correlation between the variables studied and to draw any conclusions about causality, an interesting trend may be observed with regard to the phenomena under study.

Also, an in vitro study of bone marrow-derived mesenchymal stem cells with curcumin shows an increasing trend towards M2 macrophage polarization, providing a favorable immune microenvironment for cutaneous wound healing [ 60 ].

Results showed a trend towards a non-linear J-shaped relationship of alcohol intake with BMI, with a significant positive association between alcohol consumption and BMI observed only at Very High levels of intake (>75% RDA Energy) in men and High to Very High intakes (>50% RDA Energy energy) in women.

The frequent occurrence of hypercholesterolemia in our study (57.3%), being a notable trend particularly in vitamin D-deficient children, is also worth noting.

The intestinal concretions of powder HMF may be significant enough to cause acute deterioration and warrant surgical intervention due to intestinal obstruction [ 24 , 25 , 26 ].

Also, an increasing trend of concentration of E-selectin, sICAM-1 and sVCAM-1 across the quintiles of the ‘western’ pattern was reported, suggesting that the pathogenic mechanisms may origin in endothelial dysfunction [ 33 ].

In this study the association for GI and diabetes risk was only borderline significant (HR = 1.08; 95% CI 1.00–1.17).

The hazard ratios for an association between the lipophilic index and total ischemic stroke did not indicate a clear trend across quintiles either ( Table 2 ).

All of the models that were generated were highly significant, as the p-values ranged between 0.018–0.001.

During the training period (days 29–32), we observed that as the training time extended, the escape latency of the mice in the saline/saline/saline (control) (F(3, 47) = 4.103; p < 0.05; Figure 4 D) and STZ/LiCl/MC5523 (F(3, 31) = 4.091; p < 0.05; Figure 4 D) groups showed a decreasing trend.