Excerpts

A total of 55 Korean women of different age groups, between 19 and 60+ years of age enrolled in this randomized, split-face clinical study showed highly significant improvements in skin barrier function, elasticity, and dermal density versus control treatment, possibly related to the restoration of commensal microbiota diversity observed.

If the value is higher than the table value for the 0.01 step but is less than the table value for the 0.001 steps, the differences between values are distinctly significant (**).

The SUN prospective cohort showed an inverse, weakly significant dose-response relationship for MUFAs on depression [ 9 ], while data on the protective effects of oleic acid (C18:1) are more consistent [ 56 ].

Prevalence in the general population is variable, with an average of about 1% and an increasing trend in many countries [ 3 , 4 , 5 ].

Although it was not the main aim of this study (i.e., underpowered to robustly detect effects on HOMA-IR), we nevertheless observed that BCAA restriction was associated with a decrease in HOMA-IR levels in healthy subjects assigned to the BCAA-restricted diet over seven days, with a p -value approaching significance.

A systematic review demonstrates the significant clinical benefits of fibre-supplemented enteral feeds in patients suffering from diarrhoea, with a positive trend also observed for patients with constipation [ 24 ].

We found that rat offspring born to dams fed an obesity-inducing high fat diet (HFD) exhibited a highly significant increase in local mammary tumor recurrence after initially responding to tamoxifen therapy [ 7 ].

Lipid Metabolism In the pilot study of patients with MetS, TRE led to significant reduction of atherogenic lipids such as total cholesterol (~7%), low-density lipoprotein cholesterol (LDL-C) (~11%) and non-high-density lipoprotein cholesterol levels (~9%), and a favorable trend towards reduction was found for TG and LDL-C particle number [ 16 ].

Specific improvements were noted in the UPDRS total scores and subscores, indicating a positive trend in symptom management with intranasal glutathione.

There was also a strong trend to less IgE-associated eczema, but there was no difference in “any IgE-mediated disease” [ 83 ].

A highly significant association between prescription of gastric acid suppression medication and anti-allergy drugs was detected over time [ 20 ], confirming again the allergy-protective function of gastric digestion.

In our cohort of moderate hypercholesterolemic patients, we observed a positive trend between plasma 27-OHC and non-HDL-C, but no correlations of oxysterols with TC and LDL-C, although 24-OHC levels positively correlated with apoB concentrations.

However, the placebo group showed a trend towards the deterioration of CARTS, suggesting a potential favorable effect of B12 on DAN despite the absence of a statistically significant result.

However, this risk was marginally significant for UC.

Inclusion of the interaction term resulted in a nominally significant PC2 vs. group interaction ( P FDR = 0.3883, P raw = 0.0485) showing that the effect of PC2 was stronger in the meat group (0.346) compared with dairy (0.050).

The water content of Mg may be significant not only in the water used for drinking, but also in water used for cooking, since a higher concentration of Mg in the water used for boiling may reduce the leakage of Mg in food during cooking, and may reduce the loss of Mg in the boiled food.

This might explain why we observed an association between absolute concentrations of EPA and AD dementia and a borderline significant association between the relative proportion of EPA and AD dementia but non-significant findings for the relationships between the other percentage PUFA and dementia and AD dementia.

In a meta-analysis of cohort studies, women with higher versus lower baseline serum levels of 25(OH)D had a barely significant 8% lower incidence of breast cancer [ 91 ]; the inverse association was limited to premenopausal women.

[ 73 ] on patients affected by diffuse axonal injury (a subset of TBI seen with blunt trauma to the head) [ 186 ] reported a near-significant positive trend in cognitive outcomes in the group randomised to three 360 mg capsules of boswellic acids per day compared to placebo, for whom spontaneous recovery during the study period did not approach statistical significance.

However, in the FCM group both Hb and iron showed a trend towards a decrease from 8 to 12 weeks of therapy.

Thus, PYY action on the limbic system (including the amygdala) might be significant when considering the modulation of hedonic pathways [ 20 ].

Although several religious denominations were analyzed, the categorization may not capture the diversity within each religious group; there may be significant differences in practices and beliefs within the same denominations that were not addressed in this study.

A greater part of the variability in blood lipid concentrations could be explained by the additive effects of several SNPs, which, taken individually, may only have small, and barely significant, effects [ 10 , 11 ].

General Observations Regardless of the type of diet and CCl 4 administration, rats in Groups 2–5 showed a trend toward increased body weight ( Figure 2 A).

A study performed in the United States about the trends of vitamin D concentrations showed that non-Hispanic Whites but not Hispanics and Blacks-showed a slight trend towards an increase in vitamin D levels from the year 1998 to 2010; however, Mexican-Americans in this study did not show this variation [ 20 ].