Excerpts

Eventually, severe placental oxidative stress proved to be a condition associated with a placental pathology with a highly significant prevalence of maternal vascular malperfusion, a condition derived from poor early placental development.

Both groups showed reduction in the severity of diarrhoea on day two ( p < 0.001) while, all outcomes showed a trend to be better in the ORS + Lr&Z group, without reaching statistical significance, probably due to the relatively small number of patients.

This result is in contrast with the majority of the data that reported a negative trend in MD adherence with age [ 10 , 11 ].

Also, an in vitro study of bone marrow-derived mesenchymal stem cells with curcumin shows an increasing trend towards M2 macrophage polarization, providing a favorable immune microenvironment for cutaneous wound healing [ 60 ].

Results showed a trend towards a non-linear J-shaped relationship of alcohol intake with BMI, with a significant positive association between alcohol consumption and BMI observed only at Very High levels of intake (>75% RDA Energy) in men and High to Very High intakes (>50% RDA Energy energy) in women.

The frequent occurrence of hypercholesterolemia in our study (57.3%), being a notable trend particularly in vitamin D-deficient children, is also worth noting.

The intestinal concretions of powder HMF may be significant enough to cause acute deterioration and warrant surgical intervention due to intestinal obstruction [ 24 , 25 , 26 ].

Also, an increasing trend of concentration of E-selectin, sICAM-1 and sVCAM-1 across the quintiles of the ‘western’ pattern was reported, suggesting that the pathogenic mechanisms may origin in endothelial dysfunction [ 33 ].

In this study the association for GI and diabetes risk was only borderline significant (HR = 1.08; 95% CI 1.00–1.17).

After adjustment for potential confounders as age, sex, income, physical exercise, smoking status, alcohol use, and energy intake, a positive trend was observed across quartiles of total iron intake and risk of MetS ( p for trend = 0.022).

Moreover, patients receiving EA support therapy presented a positive trend in terms of objective response rate, although no significant differences in overall survival were observed between the two groups [ 66 ].

This might be significant for the development of non-invasive biomarker panels that could substitute liver biopsy [ 21 ].

In this study, BC consumption decreased TNF-α concentrations in aged mice but not in young mice, though this effect was only moderately significant.

In this case, an increase in weight with borderline significance was shown.

Moreover, two recent meta-analyses that were specifically planned to evaluate the hypothesis that variations in the gut microbiota could explain or be used to predict obesity status in humans did not find a clear trend between the F/B ratio and obesity.

The hazard ratios for an association between the lipophilic index and total ischemic stroke did not indicate a clear trend across quintiles either ( Table 2 ).

NCGS showed a Marsh 1 grade in the 68.2%, versus the 41.5% in the other group, with a p = 0.07, close to significance.

There seems to be an increasing trend, but standard deviations are too large to draw that conclusion.

In the present analysis, a non-significant inverse correlation between abdominal muscle CSA and age, and a highly significant correlation between abdominal muscle PDFF and age in women, could be observed.

reported an increasing trend in the calculated vitamin C intake for vegetable consumption, but not for fruit consumption [ 7 ].

Regarding the average time taken for investigation of the outbreaks, there was a decreasing trend after 2008 and 2009.

Children of mothers with some university level education were less likely to have a free sugars intake ≥ 10% of EER (PR 0.82, 95% CI 0.69–0.98), while the association with being in the top tertile of free sugars intake just failed to reach significance (PR 0.83, 95% CI 0.68–1.01). 3.6.

The Australian National Nutrition and Physical Activity Survey (NNPAS) reported an increasing trend in free sugars intakes from 2–3 years of age throughout childhood, peaking in adolescence and then declining gradually through adulthood [ 8 ].

As regards the results at the end of the follow-up period, HDL-C and TMAO levels registered slightly significant variations in respect to the end of the treatment period ( Table 3 ).

Quali-Quantitative Analysis of the Polyphenolic Fraction The variability shown by the samples was taken into account, in terms of extraction yields of hydroalcoholic extracts, is highly significant in regards to the differences existing among geographic provenance, cultivars and even sub-varieties grown in the same geographic and pedoclimatic conditions but only the quali-quantitative profile obtained by HPLC-DAD analyses could show the real differences in terms of polyphenolics, and specifically for ellagitannins.