Excerpts

The results showed that three sphingomyelins significantly correlated with the abundances of several proteins, positively with 14 proteins and negatively with 29 proteins, while in total, 25 of these proteins were nominally significant between PD and control in the proteomic data alone.

7d ), and the correlation of Log 2 -Fold-Changes of nominally significant genes was low between different brain regions, and modest between 4 and 12 weeks for the same brain region (Supplementary Fig. 7e ).

Consequently, the NRE dom /PRE dom mainly features a decreasing trend in the exposed areas with global silicate rocks.

Consistently, we observed significant translational and post-translational attenuation of eQTL effect across all PhastCons score strata on top of a clear trend of decreased QTL effect size as the evolution conservation scores increase (Fig.

To further reduce the number of false positives, for each potential omics-specific QTL identified at 10% FDR we further test genotype association with the other two omics-types and remove any variant that has nominally significant association.

The FD is of resource economics traits and dominant vegetation type (herbaceous and woody wetlands) had a marginally significant interaction effect on productivity (Supplementary Table 4 and Supplementary Fig. 3a ).

3 ) shows an increasing trend in Δ F net from values below zero after March 2015 to positive values in 2019.

Values of the type-I error rate ( p ) <0.05 were considered statistically significant, and p < 0.01 and p < 0.001 were characterized as highly and very highly significant, respectively.

However, with the widest prior ranges (60 and 80), the relative risk estimates associated with NA and HA stalk were less precise, with credible intervals overlapping 1, suggesting borderline significance.

When the mean incubation period increased from 1 to 2 days, some borderline significant parameters—such as the effect of HA stalk on susceptibility and NA on infectivity—shifted slightly above 1 in the upper value of the 95% credible intervals.

In line with knock-down by siRNA, treatment with the calcium channel blocker drug nicardipine 55 or AOX1 inhibitor drug raloxifene 56 also showed a trend towards increased HDR when combined with M3814 (Fig. 3h ).

5C ), a proxy for addition of sediment-derived melts 42 , 68 , defining a positive trend.

These increases were preferentially more medially distributed and showed a trend toward the anterior portions of the striatum.

1 A shows that the total adoption rate in Washington is around 1.9% in 2022, and the incremental adoption rate presents an increasing trend from 2010 to 2022.

Latitudinal analysis revealed a clear trend: RWHPC decreases with increasing distance from the equator and increases with greater rainfall depth.

Sedimentary archives from the ECS reveal a striking divergence: while δ 13 C org exhibits an increasing trend, 10 of 13 cores show coherent declines in δ 15 N from the early 1900s to present, with an average rate of −1.09 ± 0.48‰ per century (Supplementary Figs. 8 and 9a–b ).

Conversely, a weak trend between MW and toxicity suggests that heavier compounds are less toxic.

2e shows the winter NPP calculated in the grid with the highest observation frequency, displaying a positive trend of winter NPP rate.

In contrast to the climate models, historical observations suggest that the ITF transport showed no significant trend during the past century or even an increasing trend during the recent decades when the ocean has been rapidly warming 11 , 30 , 31 , 33 , 34 .

Many of the genes involved in the 50 highest ranking triples have already been linked to AML in the literature (see SI for Table S3 for a list of highly significant triples and Table S4 with links to the literature associating the involved genes with AML).

Subperiod-specific, pooled RRs at the 99th percentile of daily warm-season temperatures showed a negative trend over the study period (Fig. 2c ), suggesting a decreasing vulnerability of the German population to heat over time.

Among the 2465 CHIP variable-protein pairs being compared (493 proteins × 5 CHIP variables [ DNMT3A, TET2, ASXL1, JAK2 , and composite CHIP]), 30.8% was nominally significant in at least one of the SomaScan-based and Olink-based results.

The electrochemical impedance spectroscopy (EIS) of 50 μm Li||Ni92 cells at different state of charges (SOCs) shows that the cell with the GMFN shows a decreasing trend of impedance from the 1 st to 10 th cycle (Supplementary Fig. 35 ).

These measurements reveal a clear trend of more than a 10-fold increase in surface emission as the cavity scales from D Dirac = 0 to D Dirac = 6.

Candidates have at least 100 residues (mean = 875.61 ± 2.36, n = 62374), highly significant matches with mammalian VGL-chanome members (E-value < 4.6 × 10 − 5 , phmmer ) and Pfam ion channel domains (E-value < 3.5 × 10 − 5 , hmmser ch ), best-hit matches with mammalian VGL-channels (96.54% of candidates), and the majority (86.59%) have a predicted topology with 2, 4, 6, 8, 12 or 24 transmembrane (TM) domains (Supplementary Fig. 1c ).