Excerpts

mRNA expression of the re-epithelialization marker Cdh1 (encoding E-cadherin) was significantly upregulated, whereas mesenchymalization marker Cdh2 (encoding N-cadherin) showed a trend toward reduction (Supplementary Fig. 1H ).

Therefore, the nominally significant results should be interpreted with caution and need to be validated in our planned new phase 2/3 trial.

It is worth noting that an increasing trend of small LiF precipitates is observed at higher F dopant concentrations, as shown in Supplementary Fig. 7 .

Moreover, the relatively wide confidence interval, which approaches statistical significance, suggests that a larger sample size or longer follow-up may be necessary to definitively assess the cardiovascular impact of combination therapy in MASLD patients.

In contrast, the uptake efficiency by hepatocytes exhibited an increasing trend as the mass ratio of PEI 25k -GalNAc to siRNA approached 2:1 (Supplementary Fig. 4 ).

Further examination of these genera showed a trend towards lower ARG counts in Enterococcus , Escherichia , and Klebsiella strains within the PS cohort compared to NPS, though differences were not statistically significant (Fig. 3c ).

The interaction model in APOE ε3/ε3 shows no significant p value for 19q13.31 :rs10423769-A in Africans, NOCT :rs13116075-G in African Admixed ancestry, CASS4 :rs6024870-A in Complex Admixed History, and LRRC37A :rs2732703-G in American Admixed ancestry, but highly significant p values for APOE :rs449647-T and TOMM40 :rs11556505-T in European and NOCT :rs13116075-G in Africans, with opposite directional effects compared to APOE ε4 carriers.

In fact, compared to NCD feeding, HFD itself increased ASC death in M- Tipe2 +/+ mice, largely due to its contribution to TIPE2 loss in macrophages; even in NCD condition, TIPE2 deficiency in macrophages also caused an increasing trend of ASC death (Supplementary Fig. 6f–h ).

Additionally, the expression level of nuclear respiratory factor 1 (NRF1) and transcription factor A (TFAM) exhibit an increasing trend upon exogenous expression of LplA, indicating that mitochondrial biogenesis is activated (Fig. 3p ).

Compared with that in the Fe 3 O 4 group and other groups, the absorption of MB clearly significantly decreased, whereas the O 2 production ability significantly increased in the FBFO and Laser groups (Fig. 2f, g ).

Even when the top three PCs (the explained variance was 46.7%, which was similar to that of the top five PCs in mTh LCN →M2 axons) were used, the difference was apparent at the pull onset (Supplementary Fig. 13g ).

This number of permutations was selected to get more precise probabilities, as the P values of some genes resulted marginally significant when performing the permutation tests with fewer repeats (1000−10000).

The velocity vectors pointed to directions consistent with an increasing trend of the percentage of viral RNAs in individual cells, which inherently served as an indicator of the infection time course 40 .

5B ), a clear trend of decreasing ancestry with increasing distance can be observed (dashed pink line, Fig. 5B ; solid black line, Supplementary Fig. 3 ; slope = − 7.554537e-05, r 2 = 0.366, p -value < 0.001).

In addition, baseline serum corisin levels exhibited an increasing trend in patients with diabetic nephropathy who experienced a greater decline in eGFR over a two-year follow-up period (>4 mL/min/1.73 m2) compared to those with a lesser decline (<4 mL/min/1.73 m2), suggesting a potential role of corisin in the progression of kidney function deterioration in diabetic CKD patients (Supplementary Fig. 3 ).

An obvious trend is the lengthening of the Warburg region as the loading density increases.

This leads to a notable enhancement in the thermal transport, with plateaus observed above room temperature in the thermal conductivities of CsAg 5 Te 3 and Cs 3 Bi 2 I 9 , or even an increasing trend in argyrodites 24 – 26 .

Interestingly, we observed that the expression levels of the full-length SlSPX5 transcript in the lines containing the deletion were not significantly down-regulated compared to those under Pi-replete condition, but rather showed a trend of induction by Pi deficiency (Fig. 6c ).

We found a highly significant overlap of genes regulated in the same direction (up or down relative to Col-0 control) in phot2 and camta2 in both temperatures [Fig. 3E ].

Meanwhile, the mass change of the Pt quartz electrode showed a trend of slight decline followed by an increase (Fig. 4c ).

Of the three female-specific regions (gwas-pw), two contain genome-wide significant SNPs in females only and the third includes a SNP nearing significance in females only (Supplementary Fig. 11 ).

We observed significant PFS benefit and marginally significant OS benefit for ICI-treated samples with high relative proportions of mregDCs (Fig. 3B ).

The comparisons demonstrated a highly significant correlation of signal intensities ( R 2 = 0.78) indicating that the majority of origins are impacted similarly by the two ADN treatments (Fig. 2e, f ).

Preliminary results indicated that patients with residual motor function (e.g., post-stroke and incomplete SCI) exhibited a slight trend of reduction in RMSE over time within a single session, without corresponding changes in motor or stimulation currents (Supplementary Figs. 8 and 9 ).

The results showed a trend towards higher anxiety levels in Gtf2i -KO mice, indicated by their spending less time in the open arms compared to controls (Fig. 4C , mean control 249.1 ± 19.62 s, mean Gtf2i -KO 200.3 ± 16.59 s).