Excerpts

This analysis leads us to discuss why submesoscale dynamics might be significant for ecosystem diversity, but less important for marine productivity.

Strikingly, TetO-YAP:Cas9 mice infected with AAV-Cre-sgRNA-Nuak2 demonstrated a substantial and highly significant reduction in liver overgrowth and hepatocyte proliferation (Fig. 2b, c ).

Differentially methylated regions in CSS/NCBRS The identified probes in the three sets showed a trend towards co-occurrences within genes (Supplementary Data 1 – 3 ).

Based on theoretical considerations on the relationship of canopy, volume, and individual tree mortality (see Supplementary Note 1 ), in conjunction with increasing growing stock 39 and harvesting intensity 43 across Europe, we expected a high correlation between canopy mortality and wood extraction but a negative trend in individual tree mortality.

We finally summarized all posterior distributions with regard to their median and 95% credible interval (2.5% and 97.5% quantile of the posterior) and calculated the probability of a positive trend ( P ( α > 0)).

2d ) showed a trend similar to that of junctional Myosin-II and previously described tension distribution.

Re-expression of TRIM24 showed a trend in rescuing tumor growth but the change was not statistically significant.

We observed highly significant upregulation of TRIM28 mRNA in metastatic PCa as compared to benign and/or localized PCa in multiple microarray datasets 3 , 44 , 45 (Fig. 6a, b ).

The absence of an increasing trend in long-term positions may be seen as encouraging.

This results in data points with low p values (highly significant) appearing toward the top of the plot.

There was only a marginally significant difference in CFU-G, and slight reduction in CFU-M, but consistent with studies of fetal livers, results show marked decreases in CFU-Mk and CFU-E formation in chromosome 21 silenced samples of transgenic subclones, (Fig. 5a ).

In contrast, the NS1 IgG3 subclass levels showed a trend to be higher in patients with DF (median 0.04, IQR: 0.03–0.06) compared with those with DHF (median 0.02, IQR: 0.01–0.03) although this was not significant ( p = 0.1).

The two closely adsorbed H exhibit a favorable trend for combination in structural configuration for potentially efficient H 2 generation.

Accordingly, mature brain tissues show a significant TREND-lengthening phenotype compared to embryonic stem (ES) cells (Supplementary Figure 7c ) including all four representative transcripts from the APA-affected module with a role in neurodifferentiation (GNB1, AES, IGF1R and EIF2S1; Fig. 4b ).

Double KO mice showed a trend towards a reduction in mean frequency and mean amplitude of IPSCs that was similar to that of Nlgn2 KO mice (Fig. 7c, e , purple bars).

There was also a nonsignificant trend toward a decrease in Complex II activity (Fig. 2c ).

A model that included (Table 2 , model 1) sex, disease severity (total Mayo clinical and endoscopic severity score), and histologic characterization of rectal eosinophils agreed with the model for the full cohort, adding sex with borderline significance.

Complementary loss-of-function approaches validated the specificity of the Ddr dn -induced phenotype, as lineage-specific RNAi using short hairpin microRNA (shmiR) constructs showed a trend suggesting synergy with low doses of Ddr dn to cause a penetrant de-adhesion phenotype (Supplementary Figure 4 ).

America showed no trend in percent fire-induced forest loss, and Africa showed a decreasing trend (Supplementary Fig. 3a ).

Trend analysis of these short-term records showed an increasing trend in percent fire-induced forest loss in Eurasia, the western US, and Australia.

During marine isotope stage 5 (MIS 5), three negative peaks in the loess δ 13 C IC exhibit a decreasing trend from MIS 5e to MIS 5a, corresponding to changing summer insolation maxima.

When we plotted the ED 50 values for morphine analgesia in WT, S375A, 10S/T-A and 11S/T-A mice against their respective ED 50 values for respiratory depression and constipation we found highly significant correlations (Fig. 4 , Supplementary Table 1 ), suggesting that both opioid effects cannot be uncoupled.

By contrast, no source sector in India shows an obvious trend; the trend in total emissions from India is uncertain, and it is not clear what could be driving that trend, if one exists.

Contribution of various source sectors We find a clear trend in CH 4 emissions from China’s coal sector while other source sectors do not show a corresponding trend (Fig. 5 ).

We incorporate atmospheric CH 4 observations into an inverse model and find an increasing trend in CH 4 emissions across much of Asia, including in China and India (Figs. 2 and 3 , Supplementary Figs. 2 and 3 ).