We then validated our findings using western-blotting for AATC, which showed a trend for decreased levels in SNCA 3x already at a basal level ( p = 0.2775), with a higher tendency noted upon the addition of TNF ( p = 0.1870) (Fig. 5H ), in line with the proteomics finding.
In the case of IL-5 and IL-10, 15% (11/73) and 16.4% (12/73) of patients diagnosed <10 years ago responded, respectively, while only 4.3% (1/23) of those diagnosed >10 years ago responded, which corresponded to a nonsignificant trend ( p = 0.283 and 0.179) in the same direction as observed for IFNγ.
Additionally, tracer uptake in the blood pool of symptomatic EAE mice was significantly higher than in naïve mice (p < 0.0001), with a trend toward significance in pre-EAE mice (p = 0.29; Supplementary Fig. 3a ).
Instead, we observed a weak trend towards prolonged survival in the KRAS-driven intestinal cancer model (median survival of 502 days ( VKras G12D/+ ;Snail KI/+ ) vs 354 days ( VKras G12D/+ ); p = 0.29; Fig. 2h, i ).
The percentage of potential T-cell responses achieved in each category revealed a nonsignificant trend toward higher responses among ACPA + RA patients to the created peptides (33%) than to no change (17%; P = 0.2918) and destroyed (13%; P = 0.1692) peptide groups, in addition to significantly more frequent responses among ACPA + RA patients to the created peptides (33%) than observed for the controls by χ 2 test (2.5%; P = 0.0002; Fig. 6b ).
Although the increase of oral Veillonella showed a trend toward higher esophageal colonization, this was not statistically significant (Fisher’s exact test, p = 0.303, n = 10; Supplementary Fig. 4L ).
While CosMx had significant differences between percentage of cells based on biological cell size differences ( p = 0.023), Xenium-UM and Xenium-MM also showed a trend towards a higher percentage of cells with gene pairs of bigger biological differences ( p = 0.31).
Macrophages/monocytes showed a decreasing trend without statistical significance ( p = 0.3254) (Fig. 1e ).
Yet, in BMDMs that engulfed ACs, Wdfy3 knockout BMDMs showed a trend of higher F-actin signals (Fig. 2g , right panel, P = 0.34).
Indeed, postextinction l -DOPA administration significantly increased the number of potential CS+ offset-related vmPFC pattern reactivations (time × group: F 3,114 = 3.51, P = 0.02, partial η 2 = 0.09; n = 40), particularly 45 min after extinction and there was still a near-significant trend 90 min after extinction (post hoc two-sample t test; pre: P = 0.39; post: 10 min: P = 0.09; 45 min: T 38 = −3.05, P = 0.004, Cohen’s d = 0.97; 90 min: T 38 = −1.95, P = 0.06, Cohen’s d = 0.62; n = 40; Fig. 2e ).
This relationship was only marginally significant in monkey S (ANOVA; monkey N: 1.03, p = 0.46; monkey S: F = 1.73, p = 0.04).
While a positive trend was seen ( rightmost column, Fig. 5b , blue ), this was not significant (Pearson correlation p = 0.47, N = 33).
2c ) .When we excluded the good prognosis subgroup (Q4 PFS) from the survival analysis, the SENS signature showed a trend in separating the PFS curves of “SENS+ without the 75 th percentile” (SENS+ w/o 75 th ) and SENS─ patients (mPFS values of 9.30 and 6.30 months, respectively; p = 0.560) (Fig. 2c ).
Moreover, by looking into the pattern of change over time, we noticed that the face inversion effect did not show a decreasing trend from the second test session to the end of the HDTBR (linear trend test for the effect from BR13 to BR 43: F (1,14) = 0.01, p = 0.941), standing in stark contrast to the gradual change of the BM inversion effect during the same test period (linear trend test: F (1, 11) = 32.38, p < 0.001).
2c (red squares), and confirmed a clear trend: Δ V gradually decreases with increasing temperature and drops to zero when the temperature approaches 230 K.
AFM profiling of free-standing thin films, transferred onto silicon wafers, further confirmed that thicknesses remained below 250 nm, with a clear trend of increasing thickness with longer IP reaction times and elevated FTCS concentrations (Fig. 2g, h , Fig.
Fisher’s exact tests confirmed that these overlaps were highly significant at both stages and in both brain regions (Supplementary Data 6 ).
With vegetation regrowth on these deposits, the total OC shows an increasing trend, with peak values reaching ~4% of the pre-equilibrium state.
Compared to PBS, long-term immunized mice exhibited an increasing trend in TNF-α-producing CD69+CD4+ and CD69+CD8+ T RM cells, although the differences were not statistically significant (Fig.
GluN2B expression also showed a trend toward a decrease; however, this change did not reach statistical significance (Fig. 7a, c ).
The qPCR results of four selected genes ( Erbb4 , Sema5a , Fbln2 , and Mest were selected as they exhibited highly significant P -values, i.e., ranked among the top 20%) and were consistent with RNA-seq (Supplementary Fig. 8 ), indicating the reliability of the transcriptomic analysis.
Empirical SocialCov matrices also showed an increasing trend in the average number of contacts (correlated with both the Normalcy and Stringency indexes, Fig.
The results demonstrated that, in contrast to the WT and Com- bre2 groups, the Δ bre2 group formed significantly fewer spores; however, it exhibited an increasing trend in mycelium production, although this trend was not statistically significant (Supplementary Fig. 3C–E ).
The comparison using non-parametric tests showed that EAAs have on average lower pleiotropy than NEAAs, however with borderline significance (Supplementary Fig. 7 ).
Among selected parameters, only age was associated with remission of clinical obesity, with borderline significance (Supplementary Table 9 ).