Excerpts

Interestingly, that variant, which was only border-line nominally significant in the standard marginal model ( P = 0.058), was reported to be associated with HDL, LDL, TG, and TC ( P = 7.9 × 10 −20 , P = 1.1 × 10 −34 , P = 3.5 × 10 −28 , P = 2.5 × 10 −32 , respectively) in the Willer et al. 28 study that included 188,577 individuals (Supplementary Data 5 ).

A marginally significant linear association (Fig. 2k and Supplementary Fig. 3e ; R 2 = 0.12; P = 0.058, n = 30) was observed between patient prevalence and total length of the involved gene pairs, and no significance was observed in brain and solid tumors (Supplementary Fig. 3f, g ).

Although the effect was nearly significant, decoding accuracy did not significantly increase with gradient order ( ⍴ = −0.03, p = 0.058, Spearman’s correlation).

Stromal CD8 + T cells showed a similar tendency but with marginal significance (stromal CD8 + T cells, P = 0.058; Fig. 6d ).

For AZD0530 (also known as saracatinib, a Src and Abl inhibitor), we found a previously reported gene set for SRC signaling 22 , which consisted of eight genes, was significantly associated with the drug in CCLE ( P = 3.89 × 10 −4 , NES = 1.91) and marginally significant by the GDSC model ( P = 0.059, NES = 1.48).

Further, when using reward expectancy neurons only, no increase in the decoder’s performance was observed (Δ performance = +0.01 ± 0.02 with n = 30 neurons, p = 0.21), while there was a statistical trend increase in the decoder’s performance when excluding reward expectancy neurons (Δ performance = +0.10 ± 0.04 with n = 99 neurons, p = 0.059).

This reduction in social parasites was marginally non-significant (one-sided t -test, p = 0.059, df = 2, t = −2.65).

Comparing the two groups with linear regression analysis we found a marginally significant IPC activity by Group interaction (17 sighted controls & 19 early blind individuals, t -value = −1.95, p = 0.059, r 2 = 0.29 two-tailed, 95% CI = [−0.02, 0.0005], Fig. 6E ).

Mangrove sediment samples showed a similar pattern to the seagrass meadows and the presence of allochthonous sources had a marginally significant positive effect on the amount of CaCO 3 in the sediment ( t -value = 4.29, df = 1.81, p = 0.0596).

A difference in survival, trending towards significance, was seen between WT ( n = 11) relative to CD8 KO mice ( n = 9; p = 0.06), implanted with kinome KO GL261 glioma cells (Fig. 1c ), suggestive of CD8 T-cell-mediated selection in WT mice implanted with kinome KO GL261 glioma cells.

albicans (partial Spearman P = 0.015, R 2 = 0.57) and a clear trend with Candida genus abundance (partial Spearman P = 0.06, R 2 = 0.46; Fig.

Furthermore, a statistical trend in the interaction effect was also found F(2, 26) = 3.15, p = 0.06 in which post-hoc comparisons revealed that only in the opsin condition animals at phase 20 cm kept significantly increased defensive distances compared to phase 10 cm as well as to phase none ( p < 0.05 and p < 0.001) respectably, while no differences were found within the control group.

In the Baby Animals task, generalization accuracy was significantly associated with age, β = 0.01, SE = 0.001, t (180.6) = 8.90, p < 0.001, 95% CI [0.008, 0.012], and showed a trend toward a significant association with verbal intelligence, β = 0.003, SE = 0.002, t (180.0) = 1.90, p = 0.060, 95% CI [−0.0001, 0.007].

Mutant frontal OFs showed a trend of greater area compared to WT (2053 ± 411 μm 2 , n = 6, compared to 1562 ± 381 μm 2 , n = 6, p = 0.06), and mutant parietal OFs had a significantly greater area compared to WT (1773 ± 281 μm 2 , n = 6, compared to 1231 ± 355 μm 2 , n = 6, p = 0.02).

CD14 + monocytes were lowest in LDs and exhibited a marginally significant decreasing trend in LDs when compared to SDs ( p = 0.06).

Within the generalized estimating equations model, marginally significant time × group interaction effects were found in the FACT-B scores (quality of life) from T0 to T2 ( p = 0.06; see Table 1 ).

When we remove White 20, one of two birds with the fewest numbers ( N = 3) of HVC X recorded, all but one of the remaining birds considered individually had P values < 0.001 (16 birds), with the remaining one marginally significant ( P < 0.06), and with the group data yielding values of R = –0.75 and P < 10 −4 .

Combining these regions into a meta-ROI, we observed that the AD+LB+ group exhibited faster glucose hypometabolism than the AD+LB− group at a statistical trend level ( p = 0.06, Fig. 3C ).

We found marginally significant effects (repeated measures analysis of variance (RM ANOVA), offline: F 2,22 = 3.22, P = 0.06; online: F 2,22 = 2.72, P = 0.09); however, the differences were small and the opposite direction for on- vs. offline stimulation.

When including both vmPFC effect on k g and aIns effect on k l in the choice model, the regression with NPM was only marginally significant ( p = 0.06), meaning that residual error was roughly flat (Fig. 3b ).

Interestingly, NOD mice treated with BIBO3304 displayed a significant decrease in glucose levels (Placebo, 5.35 ± 0.11 mM; BIBO3304, 5.03 ± 0.09 mM; * P < 0.05), which is associated with a strong trend to increased insulin levels (Placebo, 73.31 ± 9.42 pM; BIBO3304, 103.2 ± 11.87 pM; P = 0.06), indicating that β-cells in a T1D environment are responsive to the inhibition of Y1 receptor signaling.

Total developmental time from egg to adult emergence ranged between 23 and 31 days and was shorter on smaller hosts (ANCOVA: F 1,109 =8.11, P <0.005, r 2 =0.05, n =112) and shorter in broods developing from larger numbers of eggs (ANCOVA: F 1,109 =32.48, P <0.001, r 2 =0.22, n =112); the interaction between these main effects was marginally nonsignificant (ANCOVA: F 1,108 =3.62, P =0.060, n =112).

RT-qPCR confirmed induction of NOTCH/TGF‐β‐pathway genes ( NOTCH1 , HES1 , TGFB2 , TGFBR2 , and ID3 ) and reduction of ASCL1 and DLL3 , with some markers showing borderline significance (e.g., TGFBR2 P = 0.06) (Fig. 9j and Supplementary Fig. 18h, l ).

The results for females were marginally significant for all villages ( N =126, r =−0.14, Student’s t -test P =0.06) and inland villages ( N =29, r =−0.27, Student’s t -test P =0.08), but not for coastal villages ( N =97, r =−0.1, Student’s t -test P =0.14).

The SI values for the non-rewarded cue were also elevated in preterm mice (Term NR =0.11 ± 0.19, Preterm NR = 0.2 ± 0.07), but the differences in their distribution between term and preterm mice were marginally significant (K-S test, D = 0.41, p = 0.06), likely due to the low number of significantly modulated neurons (Term=16 and Preterm=23).