Excerpts

Furthermore, our analyses yielded a small negative relationship between the number of antihypertensive medications taken and depressive symptoms ( β = −0.006; 95% CI [−0.011, −0.001]; p = 0.012), and a positive trend with well-being ( β = 0.007; 95% CI [0.000, 0.015]; p = 0.046).

Using human genetic data from the 1000 Genomes Project, we calculated the DH value for the NOVA1 locus, which was nominally significant at p = 0.046.

All F1 hybrid females had a full-complement (four) of pouch young, whereas many non-hybrid females had less than four pouch young, and this reduction was marginally significant by a Fisher’s exact test ( P = 0.047).

Although of marginal significance, signalling entropy was higher in the CTCs from patients exhibiting resistance (Wilcox test P =0.047, Fig. 5e ).

Diversity at two amino acid positions in SERA2 (aa93 and aa95) showed nominally significant age effects (aa93: −0.12 mismatches per year, quasi-Poisson model, P = 0.047; aa95: −0.39 mismatches per year, quasi-Poisson model, P = 0.032), but their statistical significance did not survive multiple-testing correction.

Despite many molecular evolutionary investigations, the strongest evidence for molecular convergence thus far appears to be a marginally significant (FDR-corrected P = 0.0486) enrichment of sound perception genes in which convergent and parallel amino acid substitutions were observed 2 – 4 .

4d , red data, median change = −0.207 a.u., p = 0.005, signed-rank and HB tests), and the boundary separation showed a trend towards being smaller (Fig. 4e , red data; median change = −0.025 a.u., p = 0.049, signed-rank and HB tests; Fig. 4e is not significant).

By comparison, the relationship between spiral index and CCI was weaker in the coarse version of the task, which was reflected by a marginal significance ( p = 0.049, Spearman rank correlation) in monkey R, and non-significance ( p = 0.89, Spearman rank correlation) in monkey A.

The Group × Time interaction was marginally significant [ F (2,89.432 = 3.123, p = 0.049].

Still, there was a marginally significant preference after a day (mean AUC = 0.51, t (82) = 1.99, p = 0.049), which did not remain significant after false discovery rate (FDR) correction for multiple comparisons (adjusted p = 0.056, q < 0.05).

The difference of the effect of average variability on choice consistency and confidence ratings is marginally significant (Δ β cons−conf = −0.39 ± 0.24, P = 0.049; Fig. 1 d), however, this effect becomes more pronounced when removing two participants with outlying confidence rating behavior (Δ β cons−conf = −0.53 ± 0.25, P = 0.02; Fig. 1 d and Supplementary Figs. 1 and 3 ).

Indeed, we observed a marginally significant correlation between irAE ROR and objective response rates 14 in anti-PD-1/PD-L1 therapy ( Rs = 0.44; P = 0.049; Supplementary Fig. 1 ).

Males had slightly more affected organ systems than females, although this was only nominally significant (mean and ranges: 3.55 [1–12] for males, 3.49 [1–11] for females; linear regression p = 0.049; Supplementary Fig. 1 ).

We identified seven outliers in the analysis of SmkInit and CD risk using the MR-PRESSO approach and the causal association became nominally significant after removing these outliers (beta=0.13, P = 0.049, Supplementary Table 3 ).

Although the proliferative index of Acomys fibroblasts was not significantly altered in response to 150 μM H 2 O 2 (Tukey-HSD, t = 1.93, P = 0.916), after 48 h in culture, 300 μM exposure did produce a marginally significant decrease (18.95%) in EdU + cells (Tukey-HSD, t = 3.32, P = 0.0493) (Fig. 3a and Supplementary Table 6 ).

The sds3 G1-Cas9 was tested under conditions similar to the M and P crosses in the present study, but a marginally significant inheritance bias (67%, n = 176, Fisher’s two-sided exact test, p = 0.0495) of the w U6b-GDe element was shown only in one out of the four crossing regimes (F 0 Cas9-bearing female, F 1 trans-heterozygous female), whereas the same Cas9 isoline mediated significant bias of the kmo sgRNAs inheritance in all six combinations of parental crossing in our hands (Figs. 1 – 3 ).

P- values of less than 0.05 were considered statistically significant, and a statistical trend was recognised for p- values of 0.1 ≥ P ≥ 0.05.

Five transcripts show enrichment of CELF1 binding sites in the 3′ UTR, including PCK1 , DPYS , GSTA1 , ACY1 , and BIN1 (all P < 0.05), while a sixth, PIGT , fell just short of statistical significance ( P = 0.05).

The Mann-Kendall method was then used to test the significance of the trend, which indicates a significant trend change when p < 0.05.

Factors such as age of initial sexual intercourse, duration of menstrual period, and gravida and para appeared associated with microbiota composition at one or more sites, but failed to reach statistical significance after controlling for multiple testing (permutational multivariate analysis of variance (PERMANOVA), P < 0.05 but q > 0.05, Supplementary Data 8 and 9 ).

While integrative analysis of pathways restored by the microbiota-targeted interventions did not yield any FDR-significant results in either sex, several nominally significant pathways ( p- value < 0.05) were observed, highlighting potential effects on developmental, signaling, and metabolic processes.

Our combined analysis across all race/ethnic-groups identified 32, 30, 75 and 55 nominally significant signals (at P < 0.05) out of 104, 122, 181 and 156 variants examined in association with FEV1, FVC, FEV1/FVC ratio, and COPD, respectively (Supplementary Data 3 ).

In stage 2, we investigated the SNP with the strongest association at each region in the Asian populations and found that eight were nominally significant ( P <0.05) with an effect in the same direction and generally the same order of magnitude ( Table 1 ; Supplementary Fig. 4b ).

A p -value Bonferroni-corrected for 378 independent liver enzyme loci was used to determine significance ( p < 1.3 × 10 −4 ); alleles trending toward significance ( p < 0.05) were also reported separately.

We first regress Y trc against c 1 , ⋯ , c K jointly and select the covariates with nominally significant coefficients ( p < 0.05).