Excerpts

6B, D ), and highly significant statistical differences between active MASTER-NAADP and inactive MASTER-NADP for the number of peaks (Fig. 6C ), and the mean responsiveness (Fig. 6D ).

Hematoxylin & eosin (H&E) with histopathological scoring by M.P.R., renal pathologist, in a blinded fashion showed an increase in interstitial inflammation in both diabetic groups as compared to their respective non-diabetic controls, with an increasing trend (non-statistically significant) in the diabetic NPHS2-rtTA mice as compared to the diabetic KLF6 PODTA mice (Supplementary Fig. 2a , Supplementary Table 2 ).

Although this enhancement in vitro is not as dramatic as expected, it might be significant in vivo because the actual concentration of Mst7 and Pmk1 in vivo might be much lower than that used in the in vitro assay.

We note that despite the highly significant muscle eQTL, VGLL3 was lowly expressed in human skeletal muscle (median transcripts per million (TPM): muscle = 0.9 TPM), whereas it was highly expressed in human adipose tissues (subcutaneous adipose: 24.8 TPM, visceral adipose: 17.4 TPM, GTEx 60 : Supplementary Data 8 ).

With regard to heating, the market for heat pump (HP) systems in Europe shows an increasing trend with record high installations of over 2 Mio. in 2021 16 .

For the cumulative sea ice production (SIP) in June to August of each year during 2000–2013 available from satellite estimates, there was an overall trend of increasing SIP with increasing winter SAM (Fig. 3a–n ).

The presence of an excess of highly significant P -values for cells harboring targeting gRNAs versus non-targeting controls (NTCs) also indicates that this multiplex framework successfully detects upregulation of genes from CRISPRa perturbations (Fig. 2d ).

We next performed a within-trio analysis, quantifying the difference in PGS liability between a proband and each of their parents and compared this quantity with repeated random sampling from nominally significant PGS with matching direction of effect and not linked to proband VUS HPOs (N permutations = 10,000; median PGS per proband = 168).

There was also a strong trend for the DEGs to have only one or two exons.

In quantitative terms, these four fCO 2 -products suggested that the Pacific Ocean contributed 0.04 Pg C yr −1 decade −1 of the 2010s trend in the North, while the other three fCO 2 -products (below the fCO 2 -product average) suggested that the Pacific Ocean had a negative trend in the 2010s (−0.01 Pg C yr −1 decade −1 ), as simulated by the GOBM average.

This is induced by the fact that three of the seven fCO 2 -products suggested a greater trend in the 2010s compared to the 2000s, and a fourth fCO 2 -product suggested a strong trend in both decades.

Expressions of core autophagy genes 27 showed a trend of decrease with age at both the mRNA and protein level in the liver (Supplementary Fig. 9 ), a tissue in which age-related decline in autophagy activity has been well demonstrated 28 , 29 .

Lungs of the NS8593 treated mice showed a trend towards less immune infiltration, correlating with the decreased illness exhibited by NS8593 treated mice (Fig. 8f ).

Specifically, in humans, we observed a dominant occurrence of C-mode 1 and 2 (Kruskal–Wallis test, p < 0.001) while mice occurrence of sensory-oriented C-mode 3 and 4 was observed instead (Kruskal–Wallis test, p < 0.001), with macaques showing equiprobable (Kruskal–Wallis test, p = 0.25) C-mode occurrence (although a slight trend for a mouse-like profile was apparent).

Similarly, improving cholesterol trafficking using HPγCD showed a trend toward fewer microglia dying (Supplementary Fig. 6f ).

Initially, a blank control experiment for the isomerization of 3a was explored only under the irradiation of 365 nm LEDs, of which the results presented an obvious trend of an unstopped transformation to E -isomer (Supplementary Fig. 21 ).

NTAs were less abundant than length variations (average of 13.9% of UMI), but still followed a decreasing trend from E3 to E7 (Supplementary Fig. 14c ).

The miR-302/367 family also follows an increasing trend with development, with over 400 of their targets decreasing in expression from E3 to E7.

5d ), and their body weight also maintained an increasing trend within 10 days (Supplementary Fig. 29 ).

However, it cannot detect circulating antibodies absent from the B cell sequencing database, which may be significant.

Patients assessed as the responders (partial metabolic response [PMR] and complete metabolic response [CMR]) using PERCIST/Lugano showed a trend towards improved PFS but no significant differences were observed ( P = 0.11; hazard ratio, 2.2; 95% CI, 0.8–6.6; Fig. 4f ).

We observe a general decreasing trend of the sensitivity index for the meteorological forecast, while an increasing trend for the impact function.

We found a marginally significant difference in power between the French and Dutch listening conditions in the beta band (FDR corrected for multiple comparison across all frequencies, corrected p -value = 0.06, one sampled t -test, dof = 24).

The smFRET data reveal a significant trend of lower FRET efficiencies in the apo (Fig. 4 a, b) and agonist-bound conditions (Fig. 4 c, d) for GluN1/GluN2D receptors relative to GluN1/GluN2A receptors.

The crystallinity change of the spreading P-membrane, similar to that of the E-membrane, exhibits an increasing trend and reaches 33%, which is higher than the 17% for the knife-scraping P-membrane (Supplementary Figs. 6 and 7 ).