Excerpts

Interestingly, histological analyses of iLNs of BPA +/+ mice at maximum tolerated tumor size (59 days versus 42 days of BPA −/− ) showed a trend of increase in the pigmented areas of BPA +/+ similar, yet lower than that observed in BPA −/− mice (Fig. 4a–d ).

Moreover, higher hRNase 1 expression significantly correlated with poorer survival in tumors with grade 2 in a near-significant trend (Fig. 1b ), and hRNase 1 appeared to be a more significant poor prognostic factor in breast cancer patients with lymph node (LN)-negative non-metastasis, compared with those with LN-positive metastasis (Fig. 1c ).

With increasing dendrimer generations, the modified NADH molecules became larger and the measured K M values followed an increasing trend, although there were no significant differences between AdhD-SP free and AdhD-SP encapsulated in the three different particle morphologies.

Furthermore, a similar temporal pattern of total plant taxa richness was obtained when analysing the data before taxonomic assignment and the data containing all terrestrial seed plant sequences (Methods), as indicated by the highly significant correlations of these time-series with total plant taxa richness (Supplementary Table 1 ).

Over the past four decades, the increased heat gain in the southwestern Barents Sea through AW inflow was not compensated by surface heat loss, which had a negative trend (Fig. 1c ), resulting in a strong ocean warming trend (Fig. 3a ).

Although correlations between SAM and SFRs are hardly significant on monthly time scales (Supplementary Table 1 ), the low-pass filtered time series share similar features and covary with a maximum at 11 months lag ( r = 0.70, r = 0.52 after trend removal, Supplementary Fig. 1 ).

The intercalation energies showed an increasing trend as the intercalation stage increased from Stage 1 to Stage 3: −2.46, −2.445, and −2.292 eV, respectively, because of ion repulsion between the intercalants.

The significance of the MSH3 -related locus—and the likely large effect that it exerts—are further supported by the near-significant effect that was observed in an even smaller-sized sample of HD patients ( n = 218; TRACK-HD cohort) 16 .

There is also a clear trend that the larger species formed during the recombination process have a longer lifetime than the smaller isoelectric species, which indicates that they are more stable in (i.e., they are more resistance to) an oxidative environment.

Some skeletal muscles showed a trend in decreasing mutant mtDNA (TA, gastrocnemius at 24 weeks PI), but results did not reach significance (Fig. 4b ).

The parameter δ i ,DJO ( t ) yields the following main specification based on a (almost insignificant) general effect, and a strong negative effect of about additional 1.655 percentage point reductions in growth for poor countries (i.e., having GDP per-capita [PPP] below the median in the base year): 22 δ i , DJO ( t ) = 0.00261 ⋅ T i ( t ) − T i 0 − 0.01655 ⋅ T i ( t ) − T i 0 1 GDP CAP , i ( t 0 ) < M e d i a n ( GDP CAP , i ( t 0 ) ) Kahn et al.

Individual genetic correlations were nominally significant at α = 0.05 (based on | r G |> 1.96SE) except those between body and abdomen mass and between body mass and female LRS.

While we did not find a clear trend in the association between educational level and risk of infection as reported in other countries 29 – 31 , we found that those with a doctorate degree were at highest risk, reflecting our previous findings in the Geneva population 21 ; this risk is likely linked to the type of occupations held by these individuals, most of whom worked in the healthcare sector in our sample.

Accordingly, our BA signature also correlated with the shorter survival of relapsing patients and showed a trend towards an increased frequency of peritoneal disease upon relapse (Fig. 3f , Supplementary Fig. 3d ), consistent with the pattern of metastatic spread in patients with rCRCs 12 , 13 .

By comparing vulnerabilities under two different concentration pathways (RCP 2.6 and RCP 6.0), our study reveals a clear trend of decreasing climate vulnerabilities from RCP 6.0 to RCP 2.6 for all crops, and for most of the exporting locations.

Overall, bile acid analogs were separated into multiple subnetworks and unconnected nodes with a clear trend of separating sodiated and protonated ion identities.

There was an increasing trend in male mice as well, but this was not statistically significant (Fig. 6c ).

In observations and reanalyses, only seven out of the eleven datasets show a significant trend (significant at 99%) in globally averaged Rx1day for the historical period 1982–2015, ranging from 0.02 to 0.09 mm/day/year (Supplementary Table 1 ).

This characteristic, a near-constant predicted year followed by a positive trend, is consistent with the emergence of the anthropogenic signal from the noise of natural variability 43 .

Highly significant increases in both KRAS4A and KRAS4B transcripts were found in RNAseq data from KRAS mutant versus WT lung adenocarcinoma (LUAD) tumors, but KRAS4A showed a greater fold increase (1.7) than KRAS4B (1.2) (Supplementary Fig. 9A–C ).

After adjusting for missing storms, the century-scale decrease in USA-striking HU fraction is weaker and of modest significance, largely reflecting the influence of a maximum in the 1910s (Fig. 3 ).

The adjusted basin-wide MH record retains a nominally positive trend, but the trends after 1878 are not significant, and those computed from 1851 are only marginally significant.

This procedure was performed iteratively, adding the most highly significant independent SNP to the model at each step, ending when there were no more independent SNPs that reached genome-wide significance.

With five additional protons compared to molybdenum, silver exhibits a larger increase in charge radius, perhaps indicating an increasing trend in magnitude towards doubly-magic 100 Sn.

There was a highly significant correlation ( r = 0.82 for TCID50 and r = 0.83 for plaque assays) between the infectious viral particles and viral RNA levels in the supernatants (Fig. 1h, i ), indicating that the qPCR accurately represents infectious virus particle yield but may even underestimate the effects 5 , 24 .