Excerpts

Because 30% sequence identity results in widely different e -values (from nonsignificant to highly significant), for CAZy family assignments, we examined sequence conservation (percentage identity over CAZy domain length).

Interestingly, a highly significant increase was observed in the frequency of spontaneous release events (mEJPs; Fig. 2k ), perhaps consistent with elevation in AZ markers.

Fine-mapping methods refine marginally significant loci and discard associated but noncausal SNPs by accounting for LD, often within a Bayesian perspective 14 – 17 .

The enrichment among five relevant terms is highly significant (Supplementary Table 12 ) and strengthens at higher resolutions, suggesting increasingly precise localization of causal variants.

Such magnetic field and gate modulation of superconducting Fermi arcs open up a new avenue for the manipulation of Majorana fermions, which might be significant to the topological quantum computation.

While the lack of change in CS-δ 15 N for the Magnetic Island core was used as evidence that there was no N enrichment in the coastal GBR as a result of European settlement 46 , the absence of a decreasing trend warrants further investigation.

In both colon and small intestine, we observed an increasing trend with rising degrees of CIN for mitotic (pHH3 positive) cells per crypt (Supplementary Fig. 2I, J ), and for apoptotic cells (based on morphology) per crypt (Supplementary Fig. 2K, L ).

An apparent trend in the evolution of the CHIKV IOL since its emergence in 2004 is its incremental, sequential increase in fitness for transmission by A. albopictus .

9a ), and found that patients with PARP inhibitor treatment showed a trend of higher risk of bone fracture, serious bone, or musculoskeletal pain, as well as osteoporosis/osteonecrosis, compared with patients with Physician’s Choice Treatment or Placebo (Supplementary Fig. 9b ).

For both daytime and nighttime, the relative risk (RR) curve showed an increasing trend as temperature increased beyond the MMT.

Moreover, we observed that among the events with concordant changes between both species, there was an enrichment of microexons, with a significant trend toward less inclusion in glioma (Fisher’s test p -values 5.389e–05 for RNA-seq and 5.521e–04 for Ribo-seq) (Fig. 5b ).

Gfat1 TG mice also showed a trend of thicker LV internal diameter (LVID) in systole as compared with those in the control group (Supplementary Fig. 9c ).

In contrast AML blasts within the same host showed no changes in, or a slight trend toward increased proliferation (Fig. 4b , right panel).

When a model contained a variable of interest with borderline significance, we also performed likelihood ratio testing to evaluate whether inclusion of the variable offered improved prediction of the data.

The data points appear to be quite scattered and we do not observe a clear trend in this plot.

Two other neuroimaging phenotypes showed nominally significant effects on depression, including higher MD in the ATR for MR-Egger (tMD-ATR; β = 0.107, p for MR-Egger = 0.028, p FDR = 0.166; however, the Egger intercept was not significant, p FDR = 0.432, Supplementary Fig. 11 , Supplementary Data 6 and Supplementary Table 3 ) and ICVF in SLF (tICVF-SLF; β = −0.025, p = 0.030, p FDR = 0.179 for IVW).

Numerous highly significant interactions were inferred between mo-Macs and aggressive/metastatic tumor cells involving the activation of TNF, TGF-β, and EGFR signaling pathways in tumor cells; these interactions may induce ERK-MAPK signaling, invasive mesenchymal phenotypes, and tumor growth.

Under thermoneutral conditions, glucose clearance in beige cell recipients was not statistically different to ADSC controls, although a positive trend was noted (Supplementary Fig. 15 ).

Period estimates from genes that lost rhythms in expression profiles are used here to illustrate an overall trend, rather than provide information on individual genes.

We tested these genes on an independent dataset of 4,877 cases and 6,203 controls, HIST1H1E showed nominally significant (Supplementary Table 3 ).

Near the future M 7.1 hypocenter, there was a gradual increase in φ to values above 1, while in other regions, φ-values showed low values or a decreasing trend to values of φ ~ 1 or below 1.

Genes embedded in Cluster C2 displayed a decreasing trend throughout the growth curve and mainly included genes involved in RNA processing, metabolism of coenzymes and amino acids transport and metabolism.

Pathway-level methods were also more robust against batch effects, thus enabling the aggregation of data from various cohorts, resulting in highly significant biomarkers 18 – 22 .

However, using the PathOlogist activity scores, we identified 9 significant ( q ≤ 0.05) and 31 near-significant (0.05 < q ≤ 0.25) pathways in both microarray and RNA-seq datasets.

We observed a clear trend for larger ECS volume fractions in the parkinsonian SN.