Excerpts

The resulting p ≪ 0.001 confirms a highly significant difference in protein feature adaptation across the evaluated models.

Furthermore, the 19 F T 1 of Phe20 showed a small, but marginally significant, increase from 0.68 ± 0.02 to 0.73 ± 0.02 s, indicating its slight rigidification at nanosecond timescale upon the mutation (Supplementary Fig. 6 , see also Supplementary Note in Supplementary Information).

We also examined interactions between genetic factors (the PRS and top variants) and the taxa associated with asthma; none were significant after adjusting for multiple comparisons ( q ≥ 0.90), though many were nominally significant (Supplementary Data 12 ).

For the binary system PVA/x Cu(TFSI) 2 , where “x” represents the weight ratio (WR) of Cu(TFSI) 2 to PVA, a clear trend was observed: the ionic conductivity (σ 1 ) escalated with increasing Cu(TFSI) 2 content, rising from 0.096 mS cm −1 for PVA to 1.012 mS cm −1 for PVA/60 wt% Cu(TFSI) 2 .

This phenotype was reminiscent of IRE1α β-/- mice where the percentage of CD4 + T cells showed a trend towards declining, and the percentage of CD8 + T cells was significantly diminished.

Thus, the integration of multi-modal data (e.g., text descriptions, amino-acid sequences, protein structures) represents a significant trend in the development of protein design models.

In analyses of astroglial/neuronal injury and AD-related blood biomarkers, the Cog-PASC group showed a trend toward higher GFAP levels, although this did not reach statistical significance.

Calculating the relative strength of the TSS hotspot for all disease gene sets listed in the Human Phenotype Ontology 69 , we found highly significant associations ( p adj < 10 −50 ) with over 20 neoplasms and carcinomas (mean Jaccard index JI=0.22), decreased mitochondrial activity (two phenotypes; JI=0.52), seven neurological phenotypes (JI=0.18) and defective limb development (three phenotypes; JI=0.11), Fig. 5 c.

We found a strong spearman correlation of 0.21 ( P = 1.5 × 10 −235 ) between nominally significant estimates of h ^ Y and the MR-IVW absolute deviation from the weighted estimate (Fig. 5c ) (Supplementary Data 13 ), suggesting that MR-link-2 detects region-specific pleiotropy accurately (without the knowledge of estimates from other regions).

7d ), and the correlation of Log 2 -Fold-Changes of nominally significant genes was low between different brain regions, and modest between 4 and 12 weeks for the same brain region (Supplementary Fig. 7e ).

Consequently, the NRE dom /PRE dom mainly features a decreasing trend in the exposed areas with global silicate rocks.

Consistently, we observed significant translational and post-translational attenuation of eQTL effect across all PhastCons score strata on top of a clear trend of decreased QTL effect size as the evolution conservation scores increase (Fig.

To further reduce the number of false positives, for each potential omics-specific QTL identified at 10% FDR we further test genotype association with the other two omics-types and remove any variant that has nominally significant association.

The FD is of resource economics traits and dominant vegetation type (herbaceous and woody wetlands) had a marginally significant interaction effect on productivity (Supplementary Table 4 and Supplementary Fig. 3a ).

3 ) shows an increasing trend in Δ F net from values below zero after March 2015 to positive values in 2019.

Analysis of cell populations show an increasing trend in the proportion of fibroblast after Mtb infection (Supplementary Fig. 2F ).

A positive trend in tumour-localized CAR T cell mass was observed for mice bearing cytokine-expressing tumours compared with those with unmodified tumours (+37% in SK-N-AS and +18% in SK-N-BE2c), although this did not reach statistical significance.

Combined knockdown showed a trend toward further reduction, but BAX depletion alone had the strongest impact.

5C ), a proxy for addition of sediment-derived melts 42 , 68 , defining a positive trend.

These increases were preferentially more medially distributed and showed a trend toward the anterior portions of the striatum.

1 A shows that the total adoption rate in Washington is around 1.9% in 2022, and the incremental adoption rate presents an increasing trend from 2010 to 2022.

Latitudinal analysis revealed a clear trend: RWHPC decreases with increasing distance from the equator and increases with greater rainfall depth.

2 ), combined with published δ 238 U records 16 from different stratigraphic sections, reveal a decreasing trend following the Sturtian deglaciation (Fig. 3 ).

Sedimentary archives from the ECS reveal a striking divergence: while δ 13 C org exhibits an increasing trend, 10 of 13 cores show coherent declines in δ 15 N from the early 1900s to present, with an average rate of −1.09 ± 0.48‰ per century (Supplementary Figs. 8 and 9a–b ).

Conversely, a weak trend between MW and toxicity suggests that heavier compounds are less toxic.