Excerpts

A novel locus near ITGB8 among APOE -ε4 non-carriers Specific to APOE- ε4 non-carriers, we identified a locus on chromosome 7 (lead SNP: rs73072750; MAF = 0.11) associated with worse executive functioning at baseline, with a nominally significant interaction effect ( β non-carriers = −0.06, p non-carriers = 4.67 × 10 −10 ; β carriers = 0.02, p carriers = 0.16; β interaction = 0.07, p interaction = 8.55 × 10 −6 ).

In rats fed the Accessible Fiber diet, modest but partially significant differences—explaining a relatively small proportion of the variability—were observed between colonized and non-colonized groups (ANOSIM_Bray: R = 0.1083, permutations = 999, p = 0.053; ANOSIM_Jaccard: R = 0.1629, permutations = 999, p = 0.024; Fig. 7A, B ).

2h ); their residue weight percentages calculated from thermogravimetric (TG) curves also showed an increasing trend (Supplementary Fig. 13 ).

The median estimated h 2 SNP across all 3321 edges was 3.63% and nominally significant effects were found in 1083 edges (32.6% of total) with a median h 2 SNP of 6.2%.

17 plots the decay time as a function of P eff , showing a decreasing trend with increasing irradiation power.

Although FAO dependency did not differ significantly across genotypes or treatments, a mild trend toward increased FAO reliance was observed in TNF-treated SNCA 3x ENLs under CSB6, potentially reflecting partial restoration of metabolic flexibility 74 .

In contrast, the frequency of miniature GABA-mediated events showed a trend towards a decrease in MPS IIIA (Fig. 5P ).

We found no significant effect of response presence on measured spine volume, although we observed a weak trend toward slightly larger volumes during responding sessions (Fig.

This identified highly significant decreases in multiple pathways that govern male gametocyte development within the ∆PfDPL parasites (Fig. 3f , Supplementary Fig. 5g and Supplementary Data 4j, k ).

This challenge is likely to be significant due to the high surface-to-volume ratio of 2D materials, rendering interfacial adhesion energy particularly sensitive to environmental exposure.

Consistent with prior findings 12 , activation of the pathway by RNAi knockdown of the phosphatase vhp-1 or overexpression of sek-1 and atf-7 showed a trend toward increased catp-3 mRNA expression, suggesting that p38–ATF-7 signaling may contribute to catp-3 transcriptional regulation (Fig. 5a ).

However, a notable trend emerges with ZSM-5-650: the selectivity toward ethylene, the primary dehydration product, decreases as the temperature increases.

While total ubiquitylated protein levels showed a trend toward decreased accumulation, K48-linked polyubiquitylated protein levels were significantly reduced in NACET-treated brains (Fig. 5D , Fig.

EC prediction performance showed a trend toward higher values during renewal compared to acquisition; however, renewal did not differ significantly from either acquisition or extinction after correction for multiple comparisons ( z s < 1.55, p s FDR > .10).

Similarly, in the behavioural studies, learning was highly significant at the group level during both acquisition ( z = 19.75, p FDR s < .001, d = .37, CIs = [.61, .75]) and extinction ( z = 16.11, p FDR s < .001, d = .53, CIs = [.84, 1.07]), with only 2 out of 180 individuals showing slight negative trends (see Fig. 3E ).

The age variable shows an increasing trend, with chronic disease likelihood rising steadily as women age.

In contrast, soils under higher-intensity management, which exhibited lower SOM, microbial biomass, and nutrient contents, showed a trend toward increased microbial biomass after glucose addition, while glucose mineralization was lower than in soils under lower-intensity management.

An increasing trend is observed for both maximum (red) and average (blue) values in scattering efficiency when decreasing confinement, indicating that the role of disorder is fully revealed in the strongly confined regime.

Intriguingly, 8-m-old male Lmna f/f ;AC mice exhibited a mild trend toward reduced average adipocyte size at room temperature (RT) (Fig. 4e ), accompanied by reduced mRNA levels of Ucp1 , Pgc1a , and Pparg in iWAT (Fig. 4g ).

Using grain LOX activity levels as phenotypic values, we consistently detected a highly significant GWAS signal for the Tu population grown in three different environments (Fig. 2b and Supplementary Fig. 3c, d ).

We observe a clear trend among the models: models on average categorize 86% (±0.7%) of the statements as speciesist, but only label 37% (±0.8%) of the statements as morally wrong (see Fig. 1 ).

For cholesterol metabolism, the high expression of APOE and LIPA genes in MP0 cells indicates that cholesterol metabolism in MP0 is under active regulation, with an overall trend toward enhanced cholesterol uptake, transport, and lysosome-mediated degradation, which helps maintain intracellular cholesterol homeostasis (Fig.

The VCNs showed a trend consistent with the fluorescence levels, with SRV2 RV transduced T and NK cells exhibiting slightly higher VCN values (Fig. 2e, j ).

3b ), SuSiE predominantly captured cell-type-specific patterns but missed numerous shared effects, whereas mvSuSiE excessively weighted on both cell-type-specific and shared-by-all patterns, resulting in an unexpected trend where the number of eGenes increased with the number of shared cell types.

Let \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{{\mathcal{H}}}}$$\end{document} H denote a set of marginally insignificant SNPs.