Excerpts

Lastly, iron content in cecal contents was not different between the groups but showed a trend of increased levels in both VSG groups (Fig. 3j ).

Extending the handle duplex closer to the 5′ end thus produced a clear trend, suppressing N but enhancing N′ (Fig. 3d and Supplementary Table 3 ).

However, for both PV and VM neurons there were more well-myelinated axons below the identity line, suggesting that there was a slight trend toward loss of myelin after recovery (ΔPLM for axons with >75% PLM at baseline, PV: median: –6%, range: [–82%, 15%]; VM: median: –8%, range: [–90%, 10%]) (Fig. 5e, f ).

To address whether mTOR signalling correlated with the expression of mitochondrial proteins in human tumour material, tumour TMAs were probed with antibodies directed against phosphorylated rpS6 and SDH and the data show a highly significant positive correlation (Fig. 5m ).

Assessment of common myeloid progenitors (CMPs) and granulocyte/macrophage progenitors (GMPs) in juvenile offspring, showed a trend towards increased frequencies in offspring born to IAV-infected mothers, respectively (Fig. 4d, e ).

A large and nominally significant proportion (45%) of AUD and DPW-associated SNPs were within intronic, UTR and non-coding regions of the genome (Supplementary Fig. 6 ).

These differences were highly significant for all three variants between subgroups of younger (20-50 y.o. n = 25) and older (>50 y.o. n = 25) adults in our cohort (Fig. 1i ).

For the RNA-seq data, nominally significant differentially expressed genes were used to test the enrichment of up- and down-regulated ALP pathways using Fisher’s exact test.

Please note that trigram token frequency co-varied greatly with word frequency, which could explain the marginal significance.

The nC3 cluster, however, shared a marginally significant number of specific-signature genes with cycling populations in the human fetal gland (i.e., cycling sympathoblast and chromaffin, FDR < 0.05, Fisher’s exact test, Fig. 5e ).

All of these differences were highly significant.

Although previous research has not yet detected any global trends in TC rainfall rates 19 , Lau and Zhou 20 found an increasing trend of total TC lifetime accumulate rain in the Atlantic and a decreasing trend in the northeast and northwest Pacific during two recent decades (1988–2007) using relatively low-resolution Global Precipitation Climatology Project (GPCP) data.

Overall, observations exhibit an increasing trend in the average TC rainfall rate of about 1.3% per year, a fact that is contributed mainly by the combined effect of the reduction in the inner-core rainfall rate with the increase in rainfall rate on the rainband region.

This impact on dosage is also observed at the protein level for Bag3 , as we found a highly significant linear correlation between mRNA and protein levels (Fig. 5b and Supplementary Fig. 5 ).

In the comprehensive GHG mitigation scenario that further accounts for non-CO 2 abatement measures, non-CO 2 emissions show a decreasing trend, reducing to 9.8 Gt CO 2 -eq yr −1 in 2100.

Several additional serine proteases, HTRA3 (high-temperature requirement A serine peptidase 3), DPP7 (dipeptidyl-peptidase 7), FAP (fibroblast activation protein alpha), were upregulated in human scars (Figure S6 ), and also showed a trend in mouse scars.

Quantile-quantile plots of observed versus expected P values (minor allele frequency (MAF) >0.01) for all AML cases and cytogenetically normal AML cases showed minimal inflation of test statistics across all three GWAS after adjustment for nominally significant principal components in each GWAS ( λ GC = 1.021, 1.025, and 1.055 for all AML in GWAS1, GWAS2, and GWAS3, respectively; λ GC = 1.006, 1.011, and 1.025 for cytogenetically normal in GWAS1, GWAS2, and GWAS3, respectively) (Supplementary Figs. 6 – 7 ), minimizing the possibility of hidden population stratification and cryptic relatedness.

We next tested the effect of different S100B concentrations (0.5, 1, 5, 10, and 30 μM) with 0.5 μM TauO, and observed a decreasing trend in TauO seeding activity, which was significant at the higher tested concentrations (Supplementary Fig. 19 ).

The results also suggested a decreasing trend in the sensitivity of almost all parameters from the L3 to the L1, except the nuclear degradation, indicating that the WUS nuclear level in the L3 is more sensitive to most of the biological processes studied.

The negative adjuvant TKI predictor, RB1 alterations, combined RB1 mutations and RB1 CN loss, since they were functionally similar and both presented marginal significance of treatment interaction due to small sample size of each category (Supplementary Table 3 ).

The seedling-only plots of non-subalpine species exhibit a clear trend towards historical climate values for MSP and MTWM, with a greater trend (i.e., magnitude of SORD) in burned plots on average.

Expression of TOM20 exhibited a decreasing trend with progressive hypoxia and was significantly reduced by 3 h of hypoxia (Fig. 5A, B ; F 2,15 = 3.98, p = 0.0428; n = 6 biologically independent replicates each).

We found a clear trend showing a striking downregulation of most piRNA pathway genes during the developmental transition from spermatogonia to spermatocytes (Fig. 5e ).

Children had the highest mean score value for PC1 (2.765), followed by AMD (0.142) and ASD (−2.351), and these differences were highly significant (Fig. 1C ).

Finally, PCA for T cell memory clustered variables showed a trend to separate the three groups (Supplementary Fig. 3C ).