Excerpts

For the 61,575 genes that had representative sequences in UniRef, were FDR-significant, were robust, and were associated with IBD, 2104 (3.4%) were nominally significant in the validation cohort.

SPARC models thus predict a decreasing trend in ODS lifetimes, reflecting the disequilibrium between tropospheric and stratospheric concentrations when tropospheric concentrations are increasing.

Without expectation maximization, the extreme labels (i.e., 0,1) track well with helix stability, but structures labeled between 0.1 and 0.9 do not show a clear trend of helix compaction.

During that time, global river discharges showed a trend of decreasing N:P due to human activities and P was considered the primary limiting nutrient in surface waters 95 .

A gene-set enrichment analysis against the MSigDB pathway database ( http://software.broadinstitute.org/gsea/msigdb/ ) identified the Hedgehog and Wnt pathways as highly significant gene sets associated with Meis-binding sites (Supplementary Fig. 3 ).

In contrast, EcM-associations may contribute to the neutral latitudinal trends in beta-diversity and species turnover, but contribute to an increasing trend in species nestedness of host trees with latitude (Fig. 2 ), possibly through positive PSFs and habitat adaptation 26 , 34 , 36 .

Similarly, weaker PSFs may also shape a decreasing trend of total beta-diversity for EcM trees and a neutral trend of total beta-diversity for AM trees via species turnover and species nestedness because total beta-diversity is the sum of species turnover and species nestedness.

Main effects of Group were highly significant for all three questions ( ps < 1.0 × 10 −13 ), driven by lower ratings of the NSC group.

The significance of the MSH3 -related locus—and the likely large effect that it exerts—are further supported by the near-significant effect that was observed in an even smaller-sized sample of HD patients ( n = 218; TRACK-HD cohort) 16 .

There is also a clear trend that the larger species formed during the recombination process have a longer lifetime than the smaller isoelectric species, which indicates that they are more stable in (i.e., they are more resistance to) an oxidative environment.

Some skeletal muscles showed a trend in decreasing mutant mtDNA (TA, gastrocnemius at 24 weeks PI), but results did not reach significance (Fig. 4b ).

In line with our morphological findings, Phb1-SCKO animals treated with ISRIB showed a trend toward reduced performance in the rotarod test as compared to Phb1-SCKO mice treated with vehicle (p-values Phb1-SCKO + ISRIB vs Phb1-SCKO + Veh: Day 2 = 0.0936, Day 3 = 0.0979, Day 4 = 0.0723) (Fig. 7f ).

p < 0.05 is considered to be statistically significant and p < 0.01 is extremely significant.

In addition, animals in the 3M-052-Alum group showed a trend towards lower lung pathology compared to animals in the Alum alone group.

The phosphoproteomes of fresh-frozen and formalin-fixed cells also showed a good correlation with Pearson correlation coefficients of 0.7–0.9 ( p < 0.01), an expected trend, considering that the variability is generally higher on the (phospho-)peptide level (Supplementary Fig. 5B ).

Comparison of FOXM1 and ANXA2R RNA-seq profiles showed a highly significant positive correlation between their expression levels in 33 samples from our cohort (Fig. 6E ) and in 299 TCGA glioma samples (Fig. 6F ).

First, a positive trend in luminescence quantum yield was observed from [Ru(bpy) 3 ] 2+ ( 17 ) to bis(annulation) product 31 to tris(annulation) product 33 .

Motif enrichment analysis of the differentially open regions in the NR identified a highly significant overrepresentation of the homeobox and sox TF binding motifs (Fig. 4a ; Supplementary Data 7 ).

When their average distance to the closest transcription start site (TSS) was examined, we observed a significant trend: both for NR and RPE peaks, activating CREs tend to occupy positions closer to the TSS than the repressing regions (Supplementary Fig. 5c ).

There was an overall trend of decreasing \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\langle \dot{\epsilon }\rangle$$\end{document} ⟨ ε ̇ ⟩ with increasing number of taps (Fig. 4 ).

However, this result contrasts with recent results showing that tyrannosaur juveniles outcompeted smaller theropods 109 , although we estimated marginally non-significant competition in North American carnivores (tyrannosaurs over dromaeosaurs; Supplementary Table 3 ).

Unsurprisingly, Chlamydiaceae show a highly significant association with animal host-associated microbiomes (Fig. 6b ).

At 6–8 weeks post TAM, LOH tumors showed a trend toward increased tumor numbers and significant increases in tumor size compared to both “no LOH” control groups (Fig. 1c, d ).

4g ): there was a slight trend for activity to rise shortly after the previous saccade (normalized times near −1) during short fixation durations and for activity to rise later in the interval during longer durations (Fig. 4g best-fit line slope = 0.010 ± 0.001(1/s) and offset = −0.622 ± 0.007, estimate ± SEM).

Highly significant increases in both KRAS4A and KRAS4B transcripts were found in RNAseq data from KRAS mutant versus WT lung adenocarcinoma (LUAD) tumors, but KRAS4A showed a greater fold increase (1.7) than KRAS4B (1.2) (Supplementary Fig. 9A–C ).