Barely Significant

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Interestingly, both Anzali and Haraz basins, which had the lowest recharge ratio, were the only basins that demonstrated a decreasing trend in groundwater electrical conductivity during the study period 8 .
Decline in Iran's groundwater recharge.
Nat Commun · 2023 · PMC10590393
highly significantqualifiedgold
A molecular replacement search with the kcTRP5b.1 model yielded a highly significant solution; subsequent refinement and iterative model building revealed good agreement between the design and crystal structure across the core alpha helices (Fig. 6a ), but divergence in two of the four repeat-repeat loop connections (Fig. 6b and Supplementary Fig. 10a ) leading to a globally dissimilar topology.
De novo design of knotted tandem repeat proteins.
Nat Commun · 2023 · PMC10598012
15 , we found a decreasing trend of TDP-43 binding to RNA in most of the transcripts, where alteration in the variant resulted in significant changes of binding events in the high-attention region; for example, in transcript ENST00000547986 from K562 cells shown in Fig. 8 a, a mutation of the poly-U binding peak at position 94,971
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Thus, tools to aid in the early differential diagnosis of MSA would comprise a highly significant advance. α-syn-containing deposits are the histopathologic hallmark of synucleinopathies, but α-syn accumulation is nonetheless heterogeneous in different diseases in terms of its distribution, conformation and seeding capacity.