Over the past four decades, the increased heat gain in the southwestern Barents Sea through AW inflow was not compensated by surface heat loss, which had a negative trend (Fig. 1c ), resulting in a strong ocean warming trend (Fig. 3a ).
Although correlations between SAM and SFRs are hardly significant on monthly time scales (Supplementary Table 1 ), the low-pass filtered time series share similar features and covary with a maximum at 11 months lag ( r = 0.70, r = 0.52 after trend removal, Supplementary Fig. 1 ).
A gene-set enrichment analysis against the MSigDB pathway database ( http://software.broadinstitute.org/gsea/msigdb/ ) identified the Hedgehog and Wnt pathways as highly significant gene sets associated with Meis-binding sites (Supplementary Fig. 3 ).
In contrast, EcM-associations may contribute to the neutral latitudinal trends in beta-diversity and species turnover, but contribute to an increasing trend in species nestedness of host trees with latitude (Fig. 2 ), possibly through positive PSFs and habitat adaptation 26 , 34 , 36 .
Similarly, weaker PSFs may also shape a decreasing trend of total beta-diversity for EcM trees and a neutral trend of total beta-diversity for AM trees via species turnover and species nestedness because total beta-diversity is the sum of species turnover and species nestedness.
Main effects of Group were highly significant for all three questions ( ps < 1.0 × 10 −13 ), driven by lower ratings of the NSC group.
However, the 95th percentiles of the distributions peak at 15 species for butyrate and 12 species for total biomass and display a decreasing trend with richness beyond these thresholds.
In line with our morphological findings, Phb1-SCKO animals treated with ISRIB showed a trend toward reduced performance in the rotarod test as compared to Phb1-SCKO mice treated with vehicle (p-values Phb1-SCKO + ISRIB vs Phb1-SCKO + Veh: Day 2 = 0.0936, Day 3 = 0.0979, Day 4 = 0.0723) (Fig. 7f ).
p < 0.05 is considered to be statistically significant and p < 0.01 is extremely significant.
In addition, animals in the 3M-052-Alum group showed a trend towards lower lung pathology compared to animals in the Alum alone group.
The phosphoproteomes of fresh-frozen and formalin-fixed cells also showed a good correlation with Pearson correlation coefficients of 0.7–0.9 ( p < 0.01), an expected trend, considering that the variability is generally higher on the (phospho-)peptide level (Supplementary Fig. 5B ).
Comparison of FOXM1 and ANXA2R RNA-seq profiles showed a highly significant positive correlation between their expression levels in 33 samples from our cohort (Fig. 6E ) and in 299 TCGA glioma samples (Fig. 6F ).
By comparing vulnerabilities under two different concentration pathways (RCP 2.6 and RCP 6.0), our study reveals a clear trend of decreasing climate vulnerabilities from RCP 6.0 to RCP 2.6 for all crops, and for most of the exporting locations.
Overall, bile acid analogs were separated into multiple subnetworks and unconnected nodes with a clear trend of separating sodiated and protonated ion identities.
With increasing functional distinctiveness (depicted by functional composition) of maximum canopy height, the functional distinctiveness of wood density increased, while the functional distinctiveness of leaf litter characteristics showed a decreasing trend (Fig. 2j and k ).
However, tumor-specific T cells from IRE monotherapy showed a trend of suppressed cytokine production, especially when assessed for capacity to secrete both cytokines (Supplementary Fig. 5a, d ).
There was an increasing trend in male mice as well, but this was not statistically significant (Fig. 6c ).
In observations and reanalyses, only seven out of the eleven datasets show a significant trend (significant at 99%) in globally averaged Rx1day for the historical period 1982–2015, ranging from 0.02 to 0.09 mm/day/year (Supplementary Table 1 ).
This characteristic, a near-constant predicted year followed by a positive trend, is consistent with the emergence of the anthropogenic signal from the noise of natural variability 43 .
The results presented here thus highlight the importance of these lipoproteins in mediating changes in membrane stability, an effect that could be highly significant in the crowded OM.
The carcinogen metabolism genes, GSTM1, GSTM2 , and GSTM4 are also located in this region and our eQTL analysis of breast tumor revealed highly significant associations between rs17024629 and these genes.
The larger subpopulation of cells (subcluster 0) included a subgrouping of cells, highly expressing CCL19 showing a strong trend toward more SSc fibroblasts (Fig. 3b ), the SSc CCL19 + fibroblasts clustering separately from the control CCL19 + fibroblasts (Fig. 2c ), expressing higher levels of CCL19 (Fig. 3a ) and localizing primarily perivascularly (Supplementary Fig. 4 ).
This procedure was performed iteratively, adding the most highly significant independent SNP to the model at each step, ending when there were no more independent SNPs that reached genome-wide significance.
Looking for the subset of these phenotypes available in our scan of Thr95Ile, we do find a nominally significant increase in BMD but no detectable increase in MCH or erythrocyte distribution width.
The progressive implementation of restrictions with spatially and temporally heterogeneous applications (see Table 1 ) between October 14 and November 6 (day of introduction of tiers) induced a clear trend of decline of human activities, with a decrease in the number of visitors in locations outside the residential settings and an increase in the time spent at home (Fig. 1 ).