Barely Significant

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In addition, an increased number of CD11b + Ly6C + monocytes was observed at 21 and 28 days post-Mtb infection, while a decreasing trend in the number of CD11c + MHC-II + dendritic cells, and CD11b + F4/80 + macrophages was significant at 21 and 28 days post-Mtb infection, respectively, compared to those of Mtb-infected alone (Fig. 2D, E ).
All the lead variants from these loci showed at least nominally significant association in the latest available data freeze from the publicly available FinnGen dataset (freeze version 10) for the ‘Body-mass index, inverse-rank normalized’ trait, suggesting that these single nucleotide variants (SNVs) represent valid hits (Supplementary Fig. 4 ).
highly significantqualifiedgold
Negative local genetic correlations on the 17q21.31 cytogenetic band between genu area and neuroticism implicated the closely located CRHR1 and KANSL1 genes, which were also highly significant genes observed with genu area and splicing QTLs (sQTLs) in various cortical and subcortical tissue types in the TWAS analysis.
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Calculating the relative strength of the TSS hotspot for all disease gene sets listed in the Human Phenotype Ontology 69 , we found highly significant associations ( p adj < 10 −50 ) with over 20 neoplasms and carcinomas (mean Jaccard index JI=0.22), decreased mitochondrial activity (two phenotypes; JI=0.52), seven neurological phenotypes (JI=0.18) and defective limb development (three phenotypes; JI=0.11), Fig. 5 c.