Excerpts

In spite of increasing prevalence in diabetes, we observed a decreasing trend in diabetes-associated hospitalizations.

However, it is worth mentioning that in this trial, HF hospitalizations showed a trend favouring SafeR [ 41 ].

High psychological job demands showed a trend towards a reduced risk of developing RA.

This would have resulted in highly significant results even in non-relevant differences.

[ 37 ], our results showed a trend to higher eccentric strength during the NHE in previously injured legs (ES: 1.07–1.32).

Age, diabetes duration in years, ulcer size, and severity wound score average exhibited an increasing trend for increasing grades of ischaemia severity ( Table 1 ).

Non-ischaemic patients exhibited a decreasing trend in ischaemia rates from one to two and three affected foot zones (71.1%, 22.6%, and 6.3%, respectively).

The logistic regression statistical analysis showed that, among the variables considered, the invaded margins and the tumor volume were predictors of local recurrence, the volume at borderline significance.

Our study findings show an interesting trend where adults aged more than 25 years showed higher BI and infotainment.

This has been seen as weakly significant or correlated in comparison with the use of wearable devices for healthcare management purposes.

Differently from the primary analysis, the sensitivity analysis conducted using only studies with minimally invasive surgical technique and excluding the Davine, investigation [ 19 ] in which less than 20% of patients received a thoracotomy, showed a trend to a shorter LOS in favor of OFA.

The analysis of the proportion of each ILD subtype in the total ILD population from 2015 to 2021 demonstrated an increasing trend in the proportion of CTD-ILD, but a slow decrease in the proportion of OP.

These changes, although statistically insignificant (maybe due to the small sample size and ceiling effect), represent a positive trend.

Blood results such as high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), and CK-myoglobin-binding (CK-MB) were measured according to the standard algorithm in our hospital, starting on postoperative day (POD) 1 and continuing on a daily basis until a decreasing trend was observed.

On the contrary, studies evaluating the effect of abstinence on motility, morphology, and SDF rate, although contradictory and not conclusive, showed a trend toward improvements with shorter abstinence period [ 15 ].

The authors showed a decreasing trend in semen volume in the second, third, and fourth collections after two hours of abstinence compared to the first one after 3–4 days of abstinence [ 32 ].

The thrombolysis and in-hospital mortality showed an increasing trend but did not reach statistical significance ( p = 0.07 for thrombolysis, p = 0.10 for mortality).

Unexpectedly, in our population, blood eosinophilic count did not show statistically significant differences between never and former smokers, even if it showed an increasing trend in former smokers.

In the multivariate model, we included all significant factors associated with BKV clearance and we included the delay of BKV occurrence post transplantation because the association was really close to significance and a shorter delay of initial viremia appeared to be significantly associated with BKV endpoint.

However, while the majority of PHF is managed conservatively, in recent years, an increasing trend in total shoulder arthroplasty (TSA) has been reported [ 12 , 13 ].

In contrast, highly significant differences were found in all kinetic parameters ( Table 3 ).

Several other hormonal and reproductive factors showed a trend for increased risk of CVE, such as early menopause, pregnancy at an early age, and reproductive life span, although not significantly.

However, a clear trend towards a lower proportion of venous thromboembolic history in the after group was observed (1.4% after vs. 6.2% before for DVT and 2.8% after vs. 4.3% before after for PE), suggesting that use restrictions have been partially applied in current practice.

A decreasing trend, in standardized rates, has been observed in the last few decades which is due to the improvements in primary prevention, lifestyle modification, better control of cardiovascular risk factors (CVRF), and better management and treatment, mainly interventional, in the acute phase of events [ 3 ].

Conclusions This analysis of our prospective RCT on using HBOT in severe COVID-19 confirmed the effectiveness of randomisation (except for IL-6), showed a clear trend towards fewer deaths in the HBOT group, confirmed the possibility of safely conducting HBOT in this patient group, showed a lower need for normobaric oxygenation in the group of patients treated with HBOT and demonstrated significant beneficial effects of HBOT on CRP, ferritin, LDH and CD3.