When miR-29c-3p was inhibited, Npc1 expression was up-regulated compared with the AAV-scrambled/saline group (* p < 0.05), meanwhile Npc1 expression in the AAV-anti-miR-29c/METH group showed a trend of up-regulation compared with the AAV-anti-miR-29c/saline group (* p = 0.061, Figure 6 C).
Moreover, when analysing the total counts during the first 60 min of the test ( Figure 5 B), univariate ANOVA showed an almost significant effect of drug treatment (F(3,44) = 2.643, p = 0.061).
When the gene expression was determined in fibrosis patients (n = 41) compared to the control group (n = 32), a slight trend towards upregulation in VEGFA (fold change = 1.56, p = 0.0617), CXCL8 (fold change = 1.65, p = 0.1009), and CDKN1A (fold change = 2.13, p = 0.0148) was observed, without being statistically significant with the exception of the CDKN1A gene.
Although the stability of exosomal profiles was higher than that of plasma profiles, the overall difference was marginally significant ( p = 0.0618679).
Partial correlations controlling for age ( Table 2 ) showed a significant negative correlation between D-loop methylation levels and CSF p-tau (r = −0.64; p = 0.025), and a negative correlation with a tendency towards significance between D-loop methylation and CSF t-tau (r = −0.53; p = 0.062).
Fractalkine The result for fractalkine ( CX3CL1 ) showed only a statistical trend ( p = 0.062) that did not meet the significance threshold; accordingly, this finding should not be over-interpreted.
Ratio had an F-value of 6.42 and p = 0.0155, whereas concentration showed a borderline effect ( p = 0.0575), and the concentration × lactose interaction was also near significance ( p = 0.0620).
The interaction effect between genotype and drug was also marginally significant ( p = 0.062) ( Figure 5 F).
A negative trend between PEC reduction and disease duration was observed ( p = 0.062, r = −0.357), with no correlation between disease duration and baseline PEC or baseline EREFS ( p = 0.771 and p = 0.398, respectively). 2.6.
Brain MeSH levels were also not significantly different between experimental groups and sham-kindled mice, but there was a strong trend for a main effect of stimulation ( Figure 4 B; F (3,35) = 2.683, p = 0.062).
While vascular invasion displayed a near-significant difference (Mann–Whitney U test, p = 0.062), no correlation was found with UICC stage, nodal status, grading, or recurrence ( Table 2 ).
Consistent with these urinary findings, plasma leucine concentrations were significantly lower in patients with PKU compared with controls ( p < 0.001), while plasma isoleucine only showed a trend ( p = 0.062).
EGFR was significantly up-regulated only by BDE-47 and not by BDE-209; in addition, a borderline significant down-regulation by MIX was noted ( p = 0.0621).
The effect of sex (male) approached significance in the EPI model (EPI: Coefficient β = −127.11, p = 0.0624), with a negative coefficient indicating lower EPI levels in males compared to females.
Additionally, elevated MAPK8 expression was observed in tumors graded G1/G2, although this was of borderline significance ( p = 0.063).
HbA1C shows a borderline significant association with an OR of 1.386 (95% CI: 0.983–1.953, p = 0.063). 2.3.
Finally, TBARS (thiobarbituric acid-reactive substances) levels, indicative of lipid peroxidation, did not exhibit a different pattern in response to HT, although a marginally significant time effect was observed ( p = 0.063; Figure 2 c).
Another SNP in CHRNA3 , rs938682T/C, showed a marginally significant association for variant genotypes (TC/CC) compared with the wild-type genotype (TT), with an OR = 0.68 (95% CI, 0.45–1.02; p = 0.063) in the dominant model as the fitting model.
Remarkably, a significant relationship between bulk plasma ELISA and EV LINE-1 mRNA levels was found ( R 2 = 0.41, p = 0.024), along with a near-significant relationship with EV ORF1p levels ( R 2 = 0.30, p = 0.063).
As a matter of fact, subjects with a baseline-impaired DLCO (<80% pred at T0; n = 38) showed a trend in improvement at 6 months ( p = 0.063).
TNF-α secretion did not differ in all conditions, although an increasing trend was visible in Mct10/Mct8 dKO M1 BMDMs ( p = 0.063, Figure 5 C).
Furthermore, the interaction between genotype and treatment reached a borderline significance in p-tau protein levels when normalized by the loading control ( p = 0.0638, Figure 5 C).
control, p < 0.05), while O+B showed a trend of increased global H3K4me2 compared to the olanzapine-only group ( p = 0.064) ( Figure 4 A).
Hippocampus showed a strong trend that failed to reach statistical significance (WT: 1 ± 0 vehicle vs. 1.495 ± 0.200 ZNS, p = 0.064; het: 1.605 ± 0.123 vehicle vs. 1.291 ± 0.148 ZNS, p = 0.300).
We identified a weak trend associating SNCA and GBA1 expressions with human serum albumin levels in depressive patients at inclusion (ρ = 0.164, p = 0.064, and ρ = 0.157, p = 0.079, respectively), which appeared stronger in the male subgroup (ρ = 0.315, p = 0.014; ρ = 0.230, p = 0.077), and particularly evident in medicated patients (ρ = 0.287, p = 0.019; ρ = 0.255, p = 0.042).