Excerpts

Planned comparisons showed that groups did not differ during the CS period, p = 0.16, showed a trend toward significance in the ITI, p = 0.06, and differed significantly during the Post-CS period, p = 0.04.

Tissue MCP-1 also demonstrated a trend toward significance by health status ( p = 0.06), where unhealthy animals had higher levels ( Supplementary Table S5 ).

However, the univariate survival analyses confirmed that the patients with high drebrin + T cell infiltration showed a trend toward a short RFS (hazard ratio (HR), 2.40; p = 0.06; 95% confidence interval (CI), 0.95–6.02) ( Figure 3 A).

There was a strong trend ( p = 0.06) for RG but not CP diminishing the AUC for IkBα degradation.

We recorded a significant increase in striatal ChAT + interneurons in IR-HG sham mice versus healthy CTRL and a strong trend in the same direction between IR-NG and CTRL mice ( p = 0.06) ( Figure 5 a,c).

The group treated with 30 mM Phe showed a statistically significant difference in comparison to the 2.5 mM, 5 mM, and 10 mM treatment groups, while a statistical trend was observed in comparison to the control cells (corrected p -value = 0.06).

That way, the intermediate- ( p < 0.0001) and high-stress ( p < 0.01) regimes both showed a significant relative reduction in the IVDs’ height (intermediate-stress: 26.1 ± 4.3% reduction and high-stress: 20.9 ± 1.7% reduction, respectively), and a strong trend was observed with the low-stress regime ( p = 0.06) ( Figure 1 b).

Using the fixed-effects model, we did not find a significantly greater FBG level reduction in the AGO group than SSRIs; however, a trend towards significance has been observed ( p = 0.06).

The first principal component (captured by changes in the intake of kilocalories, carbohydrates, disaccharides, sucrose, and added sugar) showed a borderline significant association with changes in leptin levels ( p = 0.060).

In our EpiPath cohort, there was a strong ELA-associated increase in immunosenescence-associated chronic inflammation, together with increased T h 17 cell numbers, although this narrowly missed significance ( p = 0.06, [ 51 ]).

The Dunn–Bonferroni post hoc test indicated that the most notable difference in thyroid volume was observed between the CT and TT genotypes, although it was still just a trend toward significance ( p = 0.06). 3.

Conjunctival Antigen-Presenting Cells The percentage of bone-marrow-derived CD45 + cells in the conjunctiva obtained by impression cytology from all three sites—superior bulbar (SB), nasal bulbar (NB), and temporal bulbar (TB)—was significantly higher in the KCS group ( p < 0.02) and approached significance in cells obtained from the SB alone ( p < 0.06).

However, we observed a decreasing trend for LDH-A staining ( p = 0.06, n = 4), showing a potential role in the ratio of decreased lactate to pyruvate ( Figure 4 D).

Although NOP receptor expression in tissue from ModTBI rats appeared lower than in sham rats, it did not quite reach significance with Dunn’s multiple comparisons test ( p = 0.0602) 24 h post-TBI ( Figure 3 a).

The results (see Figure 6 ) outlined that the dogfish that were acclimated to 75% seawater (SW) showed somewhat higher average levels of mRNA expression than fish acclimated to either SW (100%) or 120% SW, although this higher level was not quite statistically significant ( p = 0.0606 and 0.0805, respectively). 2.3.

Although borderline for statistical significance, IL-10 showed a trend for inverse correlation with C3 and C4 levels (r = −0.359, p = 0.0608 and r = −0.326, p = 0.0906, respectively).

Due to the absence of a significant group-by-time interaction (noting a statistical trend for WBCs, p = 0.061), temporal dynamics were assessed based on the pooled data from both groups.

Moreover, when analysing the total counts during the first 60 min of the test ( Figure 5 B), univariate ANOVA showed an almost significant effect of drug treatment (F(3,44) = 2.643, p = 0.061).

In this regard, GSPE showed a trend to increase mRNA levels of Sirtuin 1 ( Sirt1 ) compared to CAF-VH group in animals subjected to standard photoperiod (L12) ( p = 0.061).

Total band density for eNOS (using the non-phospho-discriminating antibody) showed an increase in the IHS group in outer medulla, with a strong trend ( p = 0.061) for cortex.

However, in the RT-only subgroup, this association was only borderline significant ( p = 0.061). 2.5.

When miR-29c-3p was inhibited, Npc1 expression was up-regulated compared with the AAV-scrambled/saline group (* p < 0.05), meanwhile Npc1 expression in the AAV-anti-miR-29c/METH group showed a trend of up-regulation compared with the AAV-anti-miR-29c/saline group (* p = 0.061, Figure 6 C).

In animals exposed to LPS alone, an increase in IBA1 staining intensity was observed at the level of a statistical trend ( p = 0.0610) ( Figure 3 and Figure 4 ).

Effect of GPR37L1KO on the Corticosterone Level after PAT A three-way ANOVA on the level of circulating corticosterone revealed a significant effect of genotype x sex [F (1,54) = 4.04, p = 0.049; Figure 6 ] and a strong trend towards significant effect of genotype [F (1,54) = 3.66, p = 0.061; Figure 6 ], age x sex [F (1,54) = 3.65, p = 0.061; Figure 6 ] with no significant effect observed for other factors ( Figure 6 ).

Pre-Conditioning Serum Leptin Levels Predict Time to Relapse (TTR) Depending on Disease Entity and Disease Stage In the discovery cohort, multivariate Cox regression analysis showed a trend towards lower relapse rates with higher serum Leptin levels (HR per log2 increase (95% CI): 0.91 (0.82–1.00); p = 0.061; Table S1 ).