Barely Significant

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Indeed, with the exception of lixisenatide, all other GLP-1 RAs showed a trend toward a reduced incidence of MACEs (i.e., time to first event of either CV death or non-fatal myocardial infarction or stroke), which was significant in most of these trials, prompting a revision to the place of this class of drugs in the treatment algorithms of professional societies [ 57 , 58 ].
Interestingly, in the context of this clinical success, a clear trend emerged quite early demonstrating that inherent features of TILs and TCR-engineered T cells resulted in durable and complete responses when treating solid cancer [ 11 , 15 , 214 , 215 , 216 ], while, for instance, the “poster child for CAR therapies” [ 217 ], the CD19-directed CAR, led to complete remissions of >88% when treating leukemia and lymphoma in clinical trials.
highly significantqualifiedgold
However, while the association with age per year (OR = 1.078 [95% CI 1.059–1.097]), male sex (OR = 3.174 [95% CI 2.081–4.480], diabetes (OR = 1.930 [95% CI 1.399–2.662] and the PNPLA3 148M risk variant (OR = 2.083 [95% CI 1.492–2.909] remained highly significant in multivariate analysis ( Table 3 ), the association with each of the SAMM50 minor alleles was lost when the regression model included the PNPLA3 I148M risk variant, suggesting that variation of SAMM50 rs3827385 and rs3761472 are linked to the risk factor PNPLA3 148M. 2.5.