Barely Significant

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looked at a risk variant of AMD in the C3 locus (rs2230199) and showed a trend towards elevated levels of the complement activation marker C3a [ 53 ]. rs2230199 is a C>G transversion; if specific knockdown of the pathogenic (G) allele by random indels (generated by active Cas9 targeting) is possible, then indeed this could be an ideal strategy.
Additionally, the activation of CB2 receptors and the modulation of iNOS/eNOS cardiac equilibrium may be significant mechanisms for mediating the cardioprotective impact of the synthetic cannabinoid agonist, WIN55,212-2, towards ischemia–reperfusion injury in an experimental model of type 2 diabetes [ 46 ].