Barely Significant

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However, while there is an increasing trend of multidrug resistance in both Gram-negative and Gram-positive bacteria, there has been a significant global decline of investment into new drug development ( Livermore, 2012 ; Woolhouse and Farrar, 2014 ).
Among the other prominent bacterial phyla, we found that the average relative richness of Patescibacteria , Bacteroidetes , and Actinobacteria showed a trend of gradual increase with increased N fertilizer inputs during the first year of the present study, and Patescibacteria and Actinobacteria showed significant positive correlations with soil NO 3 – .
The average relative richness of Actinobacteria , Bacteroidetes, and Patescibacteria gradually decreased with a prolongation of the treatment period ( Figure 4 ), with those of Bacteroidetes and Patescibacteria decreasing significantly and the decreasing trend observed for Bacteroidetes reaching an extremely significant level under continuous treatment with N 180 .
According to CAZy annotation, there was an increasing trend over the phenological periods in genes encoding GHs, GTs, PLs, CEs, AAs, and CBMs, among which the GHs, PLs, and CBMs in the withering period were present at significantly higher levels than in the regreen and grassy stages ( P < 0.05) ( Supplementary Figure S4 and Supplementary Table S6 ).
As shown in Figures 5A,B , although the F v / F m ratio in all treatment groups showed a decreasing trend along with the increasing exposure concentrations, the F v / F m ratios of SR-induced cells (N – + NaCl, SHX + NaCl, N – + H 2 O 2 , and SHX + H 2 O 2 ) were higher than those of non-SR-induced cells (NaCl and H 2 O 2 ) at every corresponding concentration.
Regional Biases Within the Western Australian regions sampled, there appeared to be an overall trend for a relatively increased presence of Ascomycota in northern sample sites and a corresponding relative increase in Basidiomycota (particularly biotrophic rusts of the Puccinia spp.) in southern sites ( Figure 2 ).