For SCFAs, butyrate was significantly associated with extreme high vaccine response (aOR:10.00, 95% CI:1.81-107.2; p=0.025), while propionate was of borderline significance (aOR:1.33, 95% CI: 0.97-1.92; p=0.091) and acetate did not show significant association (aOR:1.01, 95% CI:0.99-1.02; p=0.368).
The number of involved spinal cord segments showed a trend toward significance but did not retain it in the multivariable model (β = 0.10, 95% CI: -0.01-0.21, P = 0.091). 3.4.
The high-chimerism group showed a trend toward higher median donor γδ T cell counts ( Figure 2C , p=0.0911), suggesting improved engraftment.
The biochemical pregnancy rate per ET also showed a trend toward being higher in the treated than in the untreated group (11.4%, 4/35 vs. 5.9%, 2/34; p = 0.092), although this trend disappeared in the SET-only analysis (14.8%, 4/27 vs. 6.5%, 2/31; p = 0.402).
Compared with the HC group, the PA group showed lower anti-Hsp60 IgM levels (p = 0.0329) and a decreasing trend in anti-Hsp70 IgM levels (p = 0.0925) ( Figure 2E ).
The high vinegar intake group showed a trend toward longer PFS: the median PFS was 492 days in patients consuming ≥0.05 g compared with 151 days in those consuming less (P = 0.093) ( Figure 7 ).
The significant difference in CD4+ T cell CCR5 density was lost when CCR5 genotype-matched subgroups were compared; however, a weak trend was maintained ( P =0.093, Supplementary Table 4 ).
Results Tumor stage did not differ significantly (P = 0.173), while metastasis stage approached significance (P = 0.093), with a higher proportion of M0 cases in the PD-L1 low group.
S vs DNS ( Figure 2 ) small differences were seen for the SIRS and sepsis S and DNS groups, some of which approached significance/were significant (highlighted in bold); SIRS Day1 [lymphocytes (p = 0.0931), CRP (p = 0.1286)], Day2 (white blood cells (p = 0.0885), neutrophils (p = 0.1206) and basophils (p = 0.033) and Day5 (white blood cells (p = 0.0599), neutrophils (p = 0.0879) and lymphocytes (p = 0.1803).
This increase in average AUC value is significant compared with the immunogenicity score ( p = 0.0135) and a strong trend toward significance is observed when compared to the 7-allele method ( p = 0.0938).
Moreover, the secretion of granzyme B by CD8 + T cells was significantly increased ( P = 0.006, Figure 4E ) and that of IFN-γ showed an increasing trend ( P = 0.094, Figure 4F ) after stimulation of the anti-CD3/CD28, in response to the suppression of PTEN.
There was a slight trend toward increased NK cell degranulation when MDMs were exposed to UV-irradiated virus compared with uninfected (NT) controls ( P = 0.094, Figure 7 B).
On the other hand, expression of CXCR3 and CCR4 showed a trend towards a decrease in Exp-allo Tr1 cells compared to T conv cells (CXCR3 60.3% ± 25.51 vs 86.30% ± 7.7, p=0.0940 ; CCR4 60.3% ± 9.7 vs 93.2% ± 5.2, p=0.0759 ).
Quantifying microglia by this classification scheme we found in the cingulum bundle age-related increases in density that approached significance for both amoeboid [ F (1, 11) = 3.36, R 2 = 0.234, p = 0.0941] and hypertrophic [ F (1, 11) = 2.63, R 2 = 0.193, p = 0.1330] microglia ( Figures 6D,E ).
The frequency of NK cells showed a decreasing trend (mean (MPN) = 8% vs mean (HC) = 14%; p = 0.095) in MPN patients, but no differences were observed in the frequencies of T cells, B cells, CD3 + /CD56 + cells, or T cell subsets ( Supplemental Figure 4B ).
In pairwise comparisons, the separation between RA-ILD and RA-non-ILD groups showed a trend toward significance but did not reach the conventional threshold (R2 = 0.062, P = 0.095).
Contrary to extrafollicular area, a clear trend (p=0.0952) towards increased levels, both as frequency or normalized counts, of IFN-α2 hi cells in SLE compared to control follicles was found ( Figure 1F , Supplementary Figure S2B ), further supporting our transcriptomic findings.
AD risk showed no significant correlations, although a negative trend was observed with PDW (rg [SE] =-0.088 [0.053]; p=0.096), in line with previous epidemiological reports.
Notably, the number of SAE/patient shows a trend toward significance with more SAE in the treatment group (p=0.096).
By contrast, here we did not detect any significant genetic correlations between platelet parameters and AD risk ( Table 1B ), although PDW variability showed a trend of significance (rg [SE] = -0.088 [0.053]; p=0.096).
0% ( p =0.013), and there was a strong trend toward better OS than patients with low S727 TILs H score ( p =0.099).
The Kaplan–Meier curve in Figure 2A only showed a trend towards longer OS (log-rank p = 0.0990) in Fn + patients (78%) compared to Fn − patients (61%).
However, PHEN treatment showed a trend ( p < 0.1) toward reduced TNF-α production compared with VEH-treated arthritic rats (Figure 3 C) and PT treatment significantly inhibited TNF-α release compared with VEH- or TERB-treated arthritic rats ( p < 0.05) (Figure 3 C).
Although pregnancy status was not significantly associated with either measure of constitutive immunity in 2012, we observed an interesting trend in 2013, whereby sheep that were pregnant had lower bactericidal capacity than those that were not pregnant ( P < 0.1).
P < 0.05 was considered as “significant” (*), p < 0.01 as “highly significant” (**), p < 0.1 as “tendency (TD)”.