Excerpts

However, it is notable that in a sensitivity analysis that excluded one influential case, there was a marginally significant moderating effect of salivary total IgG on the HCMV IgG serum-saliva relation [ b = −0.00, t (82) = −1.84, p = 0.07].

About other miRNAs, miR-30a showed an interesting trend resulting higher in NR vs R (p=0.07); instead, there were no statistically significant differences in miR-21, miR-22, miR-34a, miR-125b, miR-150 and miR-155 expression between two patient groups ( Supplementary Figure S6 ).

It was revealed that in the group of parturient women, the age distribution of seropositive and seronegative women differed—29 (25, 33) years and 27 (25, 32) years, respectively (p = 0.07 borderline significant).

Renal disease is a major predictor of damage progression in SLE, and our findings of a near-significant association of IL-18 with organ damage in multivariable analysis ( p = 0.07) are supported by previous findings in a smaller study which reported increased serum IL-18 in SLE patients with organ damage ( 53 ).

No differences were observed among the groups after 8 weeks of treatment; however, memory Tregs showed a strong trend toward increased activation (HLA-DR + CD194 + ) in the L. johnsonii N6.2 treatment group after the washout period ( p = 0.07) (Table S5 in Supplementary Material).

Of note, the expression of STAT3 in M-MDSC of CoV2+ when compared to CoV2- participants approached significance (0.4 ± 0.3 vs 15.9 ± 10.6; p=0.07).

While IGHJ4 gene usage was not associated with significant differences in prognosis (p = 0.37; Figure 2D ), patients harboring IGHJ6 gene showed a trend towards inferior five-years RFS (p = 0.07; Figure 2E ).

II–IV), expression of miR-146a was higher in patients with severe GvHD (grade II–IV) compared to patients with no/mild aGvHD (grade 0–I) ( p = 0.003), while expression of miR-155 showed a trend to higher expression in patients with severe aGvHD (stage II–IV) ( p = 0.07).

Our data support this mechanism, as patients in the MAS group had a significantly higher percentage of CD8 + T cells ( P = 0.004), and an elevated CD8 + T-cell percentage showed a strong trend toward being a risk factor for MAS in the multivariate analysis ( P = 0.0703).

There was also statistical significance found for the other three biomarkers: NEU (OR = 1.032, 95% CI: 1.005-1.059, P = 0.023), NLR (OR = 1.035, 95% CI: 0.998-1.074, P = 0.071, marginally significant), and SII (OR = 1.0001, 95% CI: 1.0000-1.0003, P = 0.041).

IL-12 was the only cytokine that showed a trend of higher PHA-induced production in controllers relative to the HCs ( P= 0.071, Figure 5E ).

low expressors, only in the group of CD47 low expressors showed a trend towards the negative impact of high CD163 expression on overall survival was observed ( Figure 4H , Supplementary Figure 4A ; p=0.071 and p=0.687).

In our search for correlations between microbial translocation markers, we observed a link between rDNA and LBP ( r = 0.279, p < 0.001, Figure 2J ), and an almost significant link between sCD14 and I-FABP ( r = 0.153, p = 0.071, Figure 2K ).

There was a statistical trend for a main effect of LPS on Ifn β 1 expression in males ( p = 0.071), but there was no interaction with IH ( p = 0.961).

Prophylactic use of rituximab showed a trend toward better overall survival both in Kaplan-Meier analysis (p=0.0717) ( Figure 1H ) and the Cox model (HR=0.66; 95%CI=0.43-1.03; p=0.0687).

Only procalcitonin levels showed a marginally significant correlation (r=0.173, p=0.072).

Forgetfulness was near significance (OR: 2.356, 95% CI: 0.944–6.205, p =0.072).

In the low education group, only Animal Fluency approached significance (+0.99, P = 0.072), with other domains remaining nonsignificant.

Mixed-effects logistic regression identified macular damage (p=0.027, OR = 3.70) and optic nerve atrophy (p<0.001, OR = 6.47) as significant predictors of poor visual outcomes, while complete-type BD showed a trend toward association (p=0.072, OR = 2.00).

Pre-booster titers in males and females are at the limits of significance: the log10 difference is -0.042 AU/ml (CI 95% -0.09; -0.00) p = 0.073, where men experience a titer increase of 10%.

Considering ORR, although close to significance, a relative change in the frequency of CD21 - B-cells was not associated with ORR in the univariable analysis (OR=0.09, 95%CI=0.01-1.25, p =0.073), but reached statistical significance in the multivariable logistic regression model (OR=0.21, 95%CI=0.00-0.71.9, p =0.032). 4 Discussion There is evidence that B-cells and TLS in the tumor microenvironment might be linked to ICI treatment response ( 14 ).

Although subtype proportions did not reach statistical significance between pSS and controls (classical P = 0.61, non-classical P = 0.61), intermediate monocytes showed an increasing trend (P = 0.073), consistent with previously reported intermediate monocyte expansion in inflammatory diseases ( 33 ).

Here, we also observed a positive trend between serum sCD14 and LBP(Spearman r = 0.21, P = 0.0735).

CD169-Cre x TLR7 fl/fl mice showed a trend of reduced VSV infection in dLN as compared to Wt mice ( p = 0.0735) although the reduction was less pronounced compared to TLR7 −/− mice ( Figure 7C ).

In the final time-to-event multivariable model (including those covariates with p < 0.1 in the univariate model), no individual parameter demonstrated an independent association with mortality, though the ASV metric approached significance (HR 1.51, 95%CI: 0.96 – 2.38, p = 0.074) ( Table 2 ) .