Excerpts

In contrast, CS exposure in non-pregnant groups approached significance (p = 0.055), while in pregnant groups, it reached significance (p = 0.04).

In the spleen, the number of tetramer + CD4 + T cells in CVD 1926 Δ steD -immunized mice was almost significantly different from mice that received PBS ( p = 0.055, Mann-Whitney test), with a 2.6-fold increase in the median number of cells as compared to PBS mice ( Figure 2B ).

Of the chemokine receptors tested, only CCR6 showed borderline significant correlation with CCL18 (p = 0.055); its expression was highly correlated with T-cell presence.

Although this difference did not quite reach significance (p=0.055), collectively the results indicate that T cell-dependent antibodies contribute to the overall protection induced against GAS-M1 following immunization with GAS-2W.M1. 3.3 The 2W Th cell epitope promotes an enhanced CD4 T cell IFN-γ response in GAS-2W.M1-immunized mice Children are more susceptible to superficial GAS infections than adults and this correlates with reduced IgG3 and IFN-γ production ( 20 ).

At the 1-year follow-up, the EFS rates in the CAR-T[early] group and CAR-T[late] group were 48% and 30%, respectively, with marginal significance (P= 0.055), and similarly, the OS rates were 75% vs. 56% in favor of the CAR-T[early] group (P = 0.053) ( 79 ).

In addition, the risk of DVT in genetically predicted IBD patients had an increasing trend with marginal statistical effect in the IVW analysis (OR = 1.032, 95% CI: 0.999-1.066, p = 0.055) ( Figure 2A ).

Women with pronation showed a trend toward RTL shortening (p=0.055), possibly due to the small sample size. 3.4.

The “ENTP6 and SMOC1” combination exhibited a negative trend with borderline significance (p = 0.055).

Results suggested that patients in the NADM8 high group tend to be more sensitive to the treatment of PI3K inhibitor GDC-0941 as compared with the NADM8 low group, although it is borderline significant (P = 0.0556) due to the limited sample size ( Figure 6K ).

The drop in concentrations of procalcitonin in the UTI groups were nearly significant relative to no growth samples (p=0.0556).

The metric is seen in Figure 4B ; there is a decreasing trend in group C compared to the virally controlled adolescents with HIV-1 (P < 0.0559).

Though a statistical trend due to the small number of animals (P=0.056 for gRNA and replicating virus titers, and P=0.095 for sgRNA), the hamsters in the recipient group housing with group 2 consistently had a log or two lower median gRNA, sgRNA, and replicating viral load levels in the lungs and oral swabs than those housed with group 1 ( Figure 3D ).

Similarly, there were more children with history of food allergy in the asthmatics than in healthy controls, which appeared to be marginally significant (P=0.056).

However, when the patients were divided into two groups based on the median of observed species, the survival analysis had a trend toward significance [Log Rank p = 0.056, HR = 0.4035, 95%CI = (0.1543, 1.055)].

High S100A monocyte gene expression was associated with elevated plasma levels of protein S100A8, while the elevation of protein S100A9 was borderline significant ( p = 0.056) ( Figure 6 ).

The difference was nearly significant (p= 0.056) between mice who received isotype or anti-galectin-9.

For RFS, patients with blast level of ≥15% showed a trend of worse RFS ( sFigure 6B , P=0.056).

This difference was significant for BA.5 (p = 0.032), BN.1 (p = 0.0079), BQ.1 (p = 0.032), BQ1.1 (p = 0.016), XBB.1(P=0.032), and a strong trend for WT (p = 0.056), BA.1 (p = 0.056), and BF.7 (p=0.056).

Age ≤ 63 years (OR = 3.103, 95%CI: 1.035-9.306), CEA 6w Down (OR = 4.209, 95%CI: 1.287-13.758), and CEA 12w Down (OR = 7.267, 95%CI: 1.508-35.006) were significantly associated with higher DCR, while NLR 12w Down (OR = 4.682, 95%CI: 0.962-22.796) had marginal significance ( P = 0.056).

Nevertheless, the borderline significance of the adjusted malignancy risk (P = 0.056) suggested an emerging safety signal that would become more apparent during longer follow-up periods. 3.5 Secondary outcomes (2–6 years) Among 5,505 patients followed beyond 1 year (4,250 fast-exposure and 1,255 slow-exposure phenotypes), significant differences emerged in safety outcomes, while efficacy remained comparable ( Table 5 ).

IL-8 demonstrated only marginal significance in ROC analysis (adjusted P = 0.056) yet emerged as a robust independent predictor in Cox regression analysis.

The IFN-γ/IL-17F ratio was borderline significant to discriminate CIS from HC ( p = 0.05629).

And a decreasing trend of GSH-Px activity was observed in the TS group over the CON group on AT7 ( p = 0.057).

The median OS was 16.8 months in the ivonescimab group and 14.0 months in the placebo group, with a positive trend (HR, 0.79; 95% CI, 0.61 to 1.01; P = 0.057) ( 25 ).

Occurrence of a new miscarriage was higher and at the edge of significance (24 vs. 12%, p = 0.057) for RM patients with no dysregulation diagnosed.