Excerpts

In presence of IL-2 and IL-15 there was a significant increase in MIP-1α levels and RANTES had near significance ( P = 0.0512) at 12 h post-infection (p.i.) (data not shown).

Interestingly, the reduction in the B cell response was restricted mostly to the spike S1 + S2 proteins ( P = 0.0012), while for the NC protein only a decreasing trend was observed ( P = 0.0515) ( Figure 2B ).

Migration was significantly inhibited by CXCL17 (24–119) and a trend toward inhibition with the SUMO3-CXCL17 construct was observed, although this just failed to reach statistical significance ( p = 0.0518).

In splenocytes co-encapsulated BLG-Pep+CpG/NP lowered the percentage of Th2 cell while increasing ratios Treg/Th2 and Th1/Th2 The co-encapsulated BLG-Pep+CpG/NP pretreatment resulted in an increasing trend in CD25+FoxP3+ Treg percentage as compared to the BLG-Pep/NP+CpG/NP pretreated mice ( p =0.0518, Figure 5A ).The co-encapsulated BLG-Pep+CpG/NP pretreatment reduced the percentage of T1/ST2+ Th2 cells ( Figure 5B ) compared to the whey-sensitized group, but no difference was found on the frequencies of CXCR3+ Th1 ( Figure 5C ) and CD196+ Th17 subsets (Data not shown for Th17) in all pretreatment groups.

However, there was a borderline significant higher incidence of HLA mismatch in the ATG-T group compared to the ATG-F group (39.1% Vs. 21.2%; p=0.052, Chi-Square test).

IL-1β showed a near-significant reduction (SMD –4.14, P =0.052).

By using this analysis in the HIV+ individuals, we observed that expression of IL-32D and IL-32θ, IL-18, VEGF-A and IFNβ remained significantly associated with coronary artery atherosclerosis independently of age, smoking or statin treatment (p=0.031, p=0.042, p=0.001, p=0.029 and p=0.046, respectively), whereas TRAIL, IL-1β and FLT3L showed borderline significance (p=0.052, p=0.055, and 0.059, respectively).

The small group (N=43) of patients with cen B/B tel B/B KIR donors showed a trend towards a lower risk of relapse (multivariable Cox regression, HR 0.45, 95%-CI 0.2-1.01; p=.052) but EFS was not different (multivariable Cox regression, HR 0.78, 95%-CI 0.49-1.24; p=.3) compared to patients with non cen B/B tel B/B KIR donors.

Consistent with the previous finding that only specific genes demonstrated significant correlations ( 25 ), PEX HLA-E mRNA showed a near-significant ( P = 0.052) correlation with tumor HLA-E mRNA among the 6 genes ( Figure 5A ).

Fracture reduced the protein level of MCP-1, a regulator of monocyte/macrophage infiltration, in young mice significantly, and in aged mice with a strong trend (aged p > 0.052).

Results show significant monovariate differences in survival for 9 tumor types (BLCA, CESC, GBM, LGG, KICH, KIRC, KIRP, MESO, STAD (see Figure 4 legend for abbreviations, all p-values < 0.05; Figure 4B ), with uveal melanoma (UVM) also being very close to significance (p-value = 0.052) ( Supplementary Figure 5 ).

Participants who were not virally suppressed (i.e., HIV RNA >50 copies/mL) at week 12 (6/11) showed a trend for higher BDG levels in plasma (median 52 pg/mL, range 12–122 pg/mL) when compared to those who were virally suppressed (median 9 pg/mL, range 3–46 pg/mL; p = 0.052, Mann–Whitney U test), while there was no difference at week 24.

Among these cases, only aMPE-4 showed a significant response, evidenced by IFN-γ production and a near-significant TNF response ( p = 0.052) ( Figures 2A, B ).

Epregistry and PIRCHE-T2 showed significantly higher mismatch scores in the dnDSA + group compared to dnDSA - ( Figures 2A, B ), while PIRCHE-B showed a similar trend that narrowly missed significance ( Figure 2C , p = 0.052 ).

No significant changes in affected body surface area were observed in both treatment groups, though disulfiram-treated mice showed a trend towards improvements in clinical skin scores ( p = 0.0521) ( Figure 5B ).

This is also compatible with IC 50 -based weak and strong binders ( p = 0.264 and p = 0.311, respectively), and with %Rank-based strong binders for which the result was marginally significant ( p = 0.053; see Supplementary Table 10 ).

There was a weak correlation of borderline significance between ELISA and OPA for global protection at M12 (Rho=0.33, p=0.053).

While TMEV RNA was present in the hippocampus of TMEV-infected mice exposed to 70 ppt PFOA (Group F), differences in levels of TMEV RNA were not quite significant between not injected or sham-infected mice exposed to 70 ppt PFOA (Groups B and D, both p = 0.053).

Comparison between patients who received fewer than two DMTs prior to CLAD initiation compared to those who received two or more: a significant difference in duration until CDW during the study (borderline non-significant, p = 0.053).

This was significantly higher than the observation group (19.2%, p = 0.009, z-test) and showed a strong trend toward significance compared to the adjuvant group (32.1%, p=0.053, z-test).

12/100 [12%]), with a borderline significant difference ( p = 0.053). 3.2.4 Severity of familial Mediterranean fever in patients with and without vasculitis The FMF severity scores are summarized in Table 2 .

This association was statistically significant for all HLA antibody-positive groups and there was also a trend toward significance for DSA-positive patients with DGF (OR = 2.18, P = 0.053).

In this small group, the mean baseline RSAD2 expression in the basophils showed a trend toward higher expression compared to the poor/non-responder group (p=0.053, Supplementary Figure S5A ).

In the combined PEARL patient subsets ( n = 143), our analysis showed a trend for higher disease activity after 2 years in patients with low SOCS1 expression at baseline ( Figure 2A , p = 0.053).

While we did not observe systemic outlier samples, statistical analysis of three analytes (IL-1β, FGF-23, and FSH) became marginally significant, only in the HIV+ group (p=0.053, 0.068 and 0.085, Table 2 ).