Excerpts

We selected and monitored the gene set associated with the pro-inflammatory effects in M1 macrophages, observing that the inflammatory genes exhibited an increasing trend during the early post-transplantation period ( Figure 2E ).In contrast, maximal T cell infiltration occurred at POD7.

Although not statistically significant, SSG-NIV treatment also showed a trend for elevated levels of IL-12p70 and IL-4, two other protective cytokines in VL ( Figures 2B, C ).

Across all samples, a decreasing trend was observed in all three (CD8, CD3, and CD68) scores with increasing MSLN H-score, but correlations did not reach significance (CD8: p = 0.174; CD3: p = 0.267; CD68: p = 0.432), likely due to low sample numbers ( Figure 4C ).

3) For Stage III, immunotherapy showed a trend toward superior DFS versus chemotherapy, though statistical significance was not reached (HR = 0.28, 95%CI: 0.04-1.96, P = 0.204), and both outperformed WW (HR = 0.05, 95%CI: 0.004-0.54, P = 0.014 and HR = 0.34, 95%CI: 0.05-2.17, P = 0.113, respectively).

In contrast, SUDV-infected cells showed a trend for decreasing viral progeny production between 1 DPI and 3 DPI, suggestive of efficient control of infection compared with MARV ( Figures 2C, E ).

also observed a favorable trend of BBs use in ICIs-treated lung cancer patients, but it was not statistically significant ( 11 ); our larger sample and rigorous methodology likely yield more reliable results. β-adrenergic receptors (β-AR) are widely expressed in tumor cells, immune cells, and vascular endothelial cells.

In parallel, animals showed a trend toward elevated NF-κB expression and decreased levels of its repressor Nkrf.

We observed a positive trend of LDR-induced expression of CD25 on NK cells at 3.5 and 6-month time points, with 10 mGy and 100 mGy reaching statistical significance at 3.5 and 6-month time points, respectively ( Figure 4B ).

TGF-β1 levels showed a trend toward elevation in T1DM patients across all periodontal conditions; however, these differences did not reach statistical significance (F (1, 126) = 4.029 and p = 0.069; Figure 2G ).

Meanwhile, although the statistical results for TC, LDL, and HDL did not reach significance, there was an overall trend of improvement.

A P value < 0.05 was considered statistically significant, and P < 0.01 was considered highly significant.

In a phase II trial in metastatic castration-resistant prostate cancer ( NCT00992186 ), free CCL2 showed a trend of rapid rebound despite a manageable safety profile ( 223 ).

3.4 AHR modulation differentially affects monocyte polarization in PDAC PBMCs Analysis of monocyte subpopulations revealed that M0 monocytes remained unchanged across all treatment conditions in both AHR expression groups ( Figure 5A ), with values consistent with those of healthy PBMC and co-cultured baselines, except for Carbidopa, which showed an increasing trend in both patient groups.

Kaplan–Meier survival curves ( Figure 9 ) showed a trend toward improved survival in the High/Medium AHR group; however, the difference did not reach statistical significance (log-rank p = 0.276).

PGE2 levels ( Figure 2D ) remained statistically unchanged across all conditions but showed a modest increase following Carbidopa treatment in the High/Medium AHR group and a decreasing trend after BAY treatment in the Low AHR group, moving marginally toward levels found in cultured healthy PBMCs.

Results demonstrated that, in most subgroups, patients with poorer SII-PNI scores (1-score group and 2-score group) showed an increasing trend in mortality risk for OS ( Figure 4 ) and disease progression risk for DFS ( Supplementary Figure 3 ) compared to 0-score group, with risk exhibiting a graded dependence on score severity (higher risk in 2-score group than in 1-score group). 4.

Patients with non-keratinizing carcinoma or EBV DNA positivity showed a trend toward improved DMFS as well.Safety:S-1 maintenance chemotherapy demonstrated a favorable safety profile, with only 3.2% of patients experiencing grade 3 adverse events.

Among T and NK cells, naive or proliferative cells (CD8_Naive and NK_Pro) were enriched, while effector T-cell subsets (CD4_Tfh, CD4_Treg and CD8_Effector) showed a decreasing trend ( Figure 1D ; Supplementary Figure 4 ).

Among these, IFITM1 , IFITM3 , IRF1 , and IFNGR2 exhibited an increasing trend ( Supplementary Figure 10G ).

Consistent with our scRNA-seq data, we found that plasma IFN-α levels showed an elevated trend in IVIG non-responders ( Supplementary Figure 10E ).

Among the biomarkers analyzed, all showed a trend toward higher concentrations in IBD patients; however, only sICAM-1 and sE-selectin reached statistical significance.

As shown in Table 3 , although the overlap between simulated and experimental DEGs was modest (8 shared genes, Fisher’s p = 0.0707), 62.5 % of them displayed concordant regulation direction, and the overall fold-change correlation (r = 0.22) indicated a positive trend in expression magnitude, supporting the biological plausibility of the simulated immune response.

This enhanced approach confirmed and strengthened our earlier findings, showing a robust and highly significant correlation between accelerated disease progression and a higher burden of unstable HLA-C allotypes.

3.2 IL-18 receptor components are selectively upregulated in allergic NK and T cells In a public scRNA-seq dataset from an AC mouse model, the Il18r1 homolog of the IL-18 receptor was significantly upregulated in conjunctival tissue of allergy-model mice compared with controls (avg_log2FC = 1.15, P-adj = 0.02657758), while Il18rap (the accessory protein) showed a trend towards increased expression ( Table 2 ).

For example, participants exhibiting symptoms at Week 4 showed a trend toward elevated CCL4 (MIP-1β) levels compared to asymptomatic individuals.