Excerpts

In Cntn1 −/− animals, the small intestine-associated Peyer's Patches showed a trend for reduced cellularity compared to wild-type tissues, and within these lymphoid structures the number of CD4 + T cells, TCR-β + NK1.1 + cells, and B cells was significantly reduced in Cntn1 -deficient tissues ( Figures 7D–F ).

Although this difference was less pronounced than we had anticipated based on previous reports ( 30 ), the analysis of nasopharyngeal swab samples using the luminescent assay showed a highly significant improvement in the clinical performance of the test.

Unexpectedly, co-incubation of infected STING KO feeder cells resulted in a highly significant increase in SIINFEKL/K b expressing BMDCs which was higher in STING WT compared to KO cells ( Figure 5C ).

Consistent with this result, we also showed a trend towards a lower incidence of acute rejection in patients with pre-transplant IRP ( 23 ).

CD8 T cell cytotoxicity was increased in the menstrual effluent of patients, and genomic analyses have shown a clear trend of enriched CD8 T effector memory cells in the eutopic endometrium of patients.

We found that to predict excess mortality, depending on the time interval when the deaths occur, either the levels of GDP or the vaccination rate or both may be significant as input parameters ( Figure 7A ).

Peripheral monocyte numbers correlated positively with nitric oxide, which showed an increasing trend in a dose-dependent manner.

In this analysis, we found a trend with marginal significance for set of countries that vaccinated more rapidly, showing that the higher the average national age, the higher the excess mortality.

In the absence of infection, lung progesterone of pregnant animals showed a decreasing trend from days 4 to 14.

When the ELISA data from MS patients and controls shown in Figure 2A was assessed on the basis of carriage of these PLP response-permissive HLA types, there was still a highly significant difference between MS patients and controls for the PLP response-permissive HLA types, but not for those individuals who do not carry these HLA types ( Figure 4 ).

Overall it seems that in acute COVID-19 infection there is a trend toward a decreased TIGIT frequency on T cells compared to healthy donors while T cells in acute malaria patients generally showed a trend toward higher TIGIT frequencies compared to healthy individuals.

In contrast, for countries with higher income, GDP is not significant, but the rate of booster administration is highly significant in the model ( Figure 7B , Model 6).

RvE1 Treatment Improved the Host Immune Response to Polymicrobial Sepsis Analysis of peritoneal exudates by flow cytometry ( Figure 3A ) showed a trend for increased (although not significant) peritoneal myeloid cells at 24 h post-CLP in RvE1-treated CLP mice compared to CLP mice with vehicle administration (CLP + vehicle: 2.79 ± 1.80 (×10 6 ) vs.

In fact, the main result was marginally significant.

These EBV-specific clones showed a significant trend of increased frequency with higher severity levels of COVID-19 ( Figure 6B ).

who examined metastatic SLN, a strong trend was observed for a negative association between high counts of FOXP3 + TIL and recurrence-free and overall survival ( 32 ).

Furthermore, the time course study revealed that the migration of KikGR-red uterus-derived total DCs, CD103 – DCs, and CD103 + DCs in the dLNs showed an increasing trend by day 3.5 pc ( Figure 4E ).

OND patients without anti-HHV-6A/B IgG in CSF or absence of intrathecal antibody synthesis showed a trend to have a higher prevalence of hhv6b-miR-Ro6-2 and −3-5p than positive patients.

We found a highly significant difference of the CD39 and CD73 expression of CD4 + , CD8 + and γδ + T cells between LPL and PBMC highlighting the peculiarity of the mucosal compartment where T cells adapt their phenotype and their effector functions to this special environment ( 21 , 22 , 42 ).

They reported that triglyceride and aortic cholesterol mass, and aortic lipid peroxides, have a decreasing trend following supplementation ( 242 ).

For ocludin, ZO-1, and TLR4, all three showed a trend of increasing compared with the controls, although the result was not statistically significant.

Therefore, Hp is considered to prefer healthy gastric mucosa and presents a decreasing trend from gastritis or stomach ulcers to GC ( 28 ).

Likewise, GAS induced a significant increase in lipoxygenase catalyzed conversion to hydroxyeicosatrienoic acids (HETEs) and in particular 15-HETE, while the increase in 5-HETE did not quite reach statistical significance.

Compared with patients with PTC, the serum of HT patients has significantly lower core fucose content and a decreasing trend of Tg antibody sialylation ( 35 ).

For comparison, MS-Gal-3 activated both DC subtypes to produce more of each cytokine, either significantly or with a strong trend, than those induced using sGal-3 at 100 ng/ml.