Excerpts

While the time series analysis indicated no immediate surge in the relative frequency of HZO at the pandemic's start, it revealed a highly significant acceleration in the long-term increasing trend of HZO cases.

By disease category, the mean number of errors per case showed an increasing trend in the order of MSK (six cases, one per case), CVA (three cases, two per case), and DUS (two cases, four per case).

This near-significant association warrants prospective investigation to clarify directionality.

The manuscript has been revised to clarify that this finding represents an observed trend within the QIP context and should not be interpreted as definitive evidence of reduced infection incidence As the project primarily assessed reported awareness and practices rather than directly observed behaviors, the findings may not fully reflect actual day-to-day clinical practice.

These indicators remained strong, with a positive trend seen in cycle 2 of the QIP.

Shoulder flexion active range of motion, a primary functional outcome, showed a positive trend in 6 of 10 patients, with an average gain of 12° (range: 3°-22°; e.g., patient 5: 118° to 140°, patient 10: 165° to 180°).

Hemodynamic monitoring showed a trend toward asymptomatic arterial hypotension; available documented blood pressure values remained within a similar low-normal range, including 106/66 mmHg on day three, without symptomatic hypotension or clinically significant hemodynamic instability.

52.6%; p = 0.051) showed a strong trend but did not reach statistical significance.

Chest CT performed at initial presentation showed only two small pulmonary nodules of indeterminate significance.

For instance, a single‐center study found only a nonsignificant trend toward higher readmission rates among obese PPCM patients, likely due to insufficient statistical power [ 11 , 16 ].

Most patients experienced surgical delay, and the sub-meta-analysis showed a nonsignificant trend toward reduced inpatient mortality with early surgery, whereas the narrative synthesis revealed mixed findings.

In contrast, PP demonstrated only borderline significance across both logistic and Cox regression analyses.

The clear separation of Kaplan-Meier curves and the highly significant log-rank test underscore the strong association between increased arterial stiffness and adverse outcomes.

The attitude score showed a positive trend toward better practice, but this association was not statistically significant (p = 0.063).

The SSM demonstrated a decreasing trend with age, reaching statistical significance in selected comparisons.

Although psychological well-being also demonstrated an increasing trend, this association did not reach statistical significance.

Interestingly, although psychological well-being showed a positive trend, the association did not reach statistical significance, indicating that emotional adaptation may be influenced by additional factors such as personality traits and social support.

Variables including numeric radiosurgery dose (HR = 1.35; 95% CI 0.99-1.87; p = 0.061) and loss of coordination at clinical presentation (HR = 2.74; 95% CI 0.94-8.02; p = 0.065) showed a trend towards association but did not reach statistical significance.

The p-values observed in our data, such as 1.00 for grade and 1.00 for stage, suggest a possible trend that may become meaningful in a larger cohort study, as Zhang et al.'s study [ 16 ], which showed that TAM density in distinct tumor compartments correlates with patient outcomes.

In the second study, which used the same longitudinal trend analysis approach but used data up to 2022, the authors reported a significant association between HTP use and a decreasing trend of acute coronary syndrome hospitalisations among four subgroups in which HTP use was most prevalent (younger adults, smokers, those residing in Tokyo, and those residing in prefectures with high HTP use).

These effects were statistically significant (i.e., the 95% CIs did not span 1) for dual users and recent quitters/novel product users, and the upper 95% CI of 1 for the cohort of longer‐term quitters/novel product users suggests an effect close to significance.

Cancer type was a highly significant correlate after adjustment for all other covariates.

Early-onset preeclampsia (≤34 weeks) showed higher odds (OR 1.53), which persisted after adjustment (AOR 1.71), suggesting a possible trend toward increased hemodynamic instability in severe disease; however, statistical significance was not achieved.

Multiple gestations showed a trend toward increased risk (AOR 4.34), though not statistically significant (p=0.058).

In this regard, the 2% GI side effects with imeglimin in this study, compared with the 20%-30% rate with standard metformin, are highly significant and a finding consistent with its distinct mechanism of action [ 6 , 20 ].