Barely Significant

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EXSCEL reported a nominally significant reduction in all-cause mortality (HR: 0.86, 95% CI: 0.77-0.97) despite a neutral primary efficacy result [ 17 ], and PIONEER 6 showed lower cardiovascular and all-cause mortality (all-cause death, HR: 0.51, 95% CI: 0.31-0.84), albeit on a small number of events [ 19 ].
Third, although the power analysis revealed a favorable result, further studies with a larger sample size may reveal different findings because there was a favorable trend toward the ketorolac group in this research, though it was not statistically significant.