Barely Significant

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The XELOXA trial comparing 5-FU to a combination of CAPOX showed a trend toward benefit from the addition of oxaliplatin in terms of DFS and OS in elderly patients, although this was diminished compared to younger patients and was not statistically significant [ 66 , 67 ].
A further subpopulation analysis, including 70 patients (85%) without metastases at presentation, revealed that rWIR as a binary variable nearly approached significance, suggesting an association with EFS (HR: 2.3; 95% CI: 1.0–5.2) ( Table 3 ). rWIR as a continuous variable was significantly associated with EFS (HR: 0.7; 95% CI: 0.5–0.9).