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(healthy eating habits, individualized and guided training programs, and psychological support) showed a trend towards a lower proportion of survivors with high LDL-C in the intervention group after 15 months [ 37 ].

This model was highly significant overall, with preoperative use of thyroxine and male gender being positively associated with the risk for cancer, and advanced age and the use of antithyroid medications being negatively associated with this outcome, but Tg-Abs were not independently associated with it ( Table 4 ).

A trial combining gefitinib and cediranib, targeting EGFR and VEGFR, showed a trend towards an improved response rate in recurrent GBM patients in a phase II trial [ 61 ].

The existing literature on this subject matter now provides compelling evidence pointing towards a statistical trend in favour of extended OS and PFS in cases involving craniotomy with resection, as opposed to the purely diagnostic stereotactic biopsy procedure.

The distribution of race between the group of subjects with HCC recurrence showed a trend toward a higher proportion of White and a lower proportion of Black patients; however, this was not a statistically significant difference.

There was only a weakly significant positive association with incidence in men but not in women ( Supplementary Tables S3 and S7 ).

The presence of variant histologic patterns on biopsy showed a trend toward higher upgrading risk but did not reach statistical significance when considered in isolation.

Two-sided p -values < 5% were considered to be statistically significant and p < 10% to be borderline significant. 5.

In our cohort, the patients who underwent additional mpMRI-targeted cognitive fusion lesion sampling had a nonsignificant trend toward lower upgrading rates (34.6% vs. 41.1% with systematic biopsy alone, Δ6.5%), consistent with the modest reductions in under-grading risk reported with MRI-targeted approaches [ 50 ].

Based on the highly significant differences observed in Sp17 expression between the ID8 cell sub-clones, a single population representing each of the Sp17 + and Sp17 − cells was chosen for use in subsequent in-vivo analyses.

Together, these three modules are likely to be significant and fairly independent functional units. 2.4.

However, the results of a clinical trial with Tarextumab, an antibody inhibiting NOTCH 2/3, although initially showed a trend towards an improvement of progression-free survival in patients whose tumors expressed elevated levels of NOTCH target genes, failed to confirm this trend in in a larger cohort of patients in the context of a phase II study [ 117 ].

TGF-βRII-KD CAPAN-1 or CAPAN-2 cells also showed a trend toward increased proliferation at 96 h compared to the respective NT control cells but that remained not significant (not shown).

The incidence and mortality of colorectal cancer in China have shown an increasing trend.

Differences were considered ‘not significant’ (n.s.) with p values > 0.10, as ‘borderline significant’ with p values from 0.10 to 0.05, and as ‘significant’ with p values < 0.05.

This suggests that there might be significant issues in achieving a highly synergistic drug combination with precision in individual patients.

Although not statistically significant, elevated post-induction CA 19,9 levels showed a trend toward association with shorter post-recurrence survival.

All analyses were conducted using SPSS version 23.0 (IBM, Armonk, NY, USA) and R software, version 3.2.5 for Windows (the R foundation for statistical computing, Vienna, Austria), and p -values < 0.05 were considered statistically significant; p -values between 0.05 and 0.15 were considered as a trend toward significance. 5.

In the fixed-effects model, ABT showed a trend toward increased risk of disease progression (HR = 1.085; 95% CI: 0.995–1.176).

The loss of BAP1 showed a strong trend toward improved median survival and was associated with higher histological grade and absent lymphatic invasion [ 161 ].

The two-dimensional field of view that is offered by endoscopic navigation can be a limitation, as can the restricted surgical instrument maneuverability compared with open surgery and a possibly significant learning curve required to master the endoscope [ 41 ].

The OS data remain immature but also showed a trend towards improvement in the overall population and AKT pathway mutated population.

Lung and lymph node metastases did not reach statistical significance in rPFS analysis even though a negative trend is represented in survival curves.

Compared to the baseline (d1, cycle 1), we revealed a highly significant increase of Ab levels from cycle to cycle (1.06 ± 0.06, 1.34 ± 0.09, 1.74 ± 0.15, and 1.99 ± 0.15 μg/mL for cycle 1, 2, 3, 4 and 5, respectively) ( Figure 3 B).

High waist circumference (HR: 1.12, 95% CI: 1.04, 1.20), elevated cholesterol (HR: 1.07, 95% CI: 1.01, 1.13), and high blood pressure (HR: 1.11, 95% CI: 1.05, 1.17) were each significantly associated with higher risk of breast cancer among postmenopausal women, and there was a clear trend in increased risk with increased number of MetS components among postmenopausal women.