Excerpts

Kaplan-Meier survival analysis showed a trend of shorter progression time by interim imaging reassessment for patients with at least three CTCs (median TTP 79 days) at baseline compared to 0–2 CTC (median TTP 94 days) ( p = 0.090) ( Figure S2A ). 2.2.3.

Highly significant correlations were also found with respect to relapse-free survival (RFS) in several subsets.

In addition, regarding to the highly significant improvement in OS for patients with brain metastases, this combination may be preferred in this subgroup.

In contrast, baseline anemia was shown to be a highly significant prognosticator in the radiotherapy group.

Elderly HNSCC patients with reduced kidney function who were treated with radiotherapy alone showed a trend towards lower OS, although statistical significance was not reached ( p = 0.112).

Moreover, three of them showed a trend of upregulation during disease progression from healthy controls to primary and metastatic melanoma cases. 2.

Increasing levels of haemoglobin and CRP were significantly associated with lower disease control rates during chemotherapy, whereas haemostatic biomarkers (D-dimer, F1+2) predicted for a lower probability of disease control with borderline significance.

As it was shown in Figure 1 C, the lower staining intensity of COX5B in tumorous, when compared to nontumorous part, were associated with a better prognosis in OS, recurrence-free survival (RFS) and metastasis-free survival (MFS), albeit a borderline significance in OS.

Because this difference is highly significant, it is possible that downregulation of NRBP2 may reflect an immature, progenitor-like state of MB cells, and that loss, or reduction, of NRBP2 expression during tumor formation relates to an undifferentiated state by which MB aggressiveness increases.

LPCs showed a trend towards reduced levels in samples from CCA, which reached statistical significance in those from PDAC patients.

In Korean women, the current mean age at menopause is lower than that in other countries such as the United Kingdom, Australia, or Japan but shows an increasing trend [ 17 ], which may possibly contribute to the increased breast cancer-related burden.

Subtype was significantly associated with the presence of distant metastasis at diagnosis and showed a trend towards significant association with lymphovascular invasion (LVI) at diagnosis, with a higher proportion of cases with LVI and distant metastasis for subtype A compared with B.

The presence of distant metastasis at diagnosis and recurrence after surgery are significantly more common for subtype A PNENs, and a trend towards significance was observed for LVI at diagnosis.

Even after adjusting for the cancer stage, the positivity of the D-marker panel and cancer progression remained associated with marginal significance, and the adjusted HR (95% CI) was 1.29 (0.92 to 1.80) (Model 2).

However, the mean Cl of the 1 h cohort was (range): 32.61 (19.76–72.67) L/h/m 2 , which is higher than previously published data of Cl in push injected VCR and corresponds well with our nearly statistically significant finding of higher Cl in the 1 h group compared to the push injection group.

Highly significant Pearson correlation coefficients were found for GATA3, FOXA1, and KRT14; a good correlation was found for KRT5/6 ( Figure 1 A).

However, in their concluding experiments only a trend towards significance over the randomly labeled approach could be established.

Conclusions Elucidating the natural history of small breast tumors in the two periods revealed a decreasing trend of incidence on larger tumors but an increasing trend of incidence on small breast tumors and also shorter sojourn times in the second period that are a reflection of greater awareness of women.

While there is an apparent trend in higher PD-L1 values in the primary melanoma samples compared with the metastatic melanomas, the difference is not statistically significant, as the p values of this comparison is 0.11, with wide overlapping interquartile values.

While tumour burden is likely to condition the patient’s survival and may explain the association between ctDNA detection and OS, ctDNA detection was less correlated with PFS in this study and was not significantly independent from other prognostic factors, despite a clear trend.

IL33Rα showed an association of borderline significance with cancer-related death, whereas highly significant associations were observed for the tumor characteristics and CRP levels.

The Eastern Cooperative Oncology Group (ECOG) performance status showed an association of borderline significance, whereas the Charlson comorbidity index and the American Society of Anesthesiologists (ASA) physical classification score showed no associations.

In this proof-of-concept study, a mild trend for reduced tumor volumes was observed when AAV vectors expressing anti-PD-1 scFv were combined with chemotherapy [ 189 ].

Moreover, an increasing trend was observed for administration of higher than prophylactic doses, with regards to the clinical oncology setting (line of systemic anticancer treatment).

Due to the limited number of samples, it was not possible to evaluate the significance of these values, which however show a positive trend. 3.