Excerpts

A slight trend towards higher levels of these cell populations was seen in the subcutaneous tumours.

Focusing on headaches (BN 20, Figure 7 A), there was an increase in headaches observed during treatment, which improved at year 1 after PT similar to baseline, after that showing a slight trend to worsen.

found a decreasing trend in bacterial diversity from non-atrophic gastritis (NAG) to intestinal metaplasia (IM) and then to intestinal-type gastric cancer [ 41 , 47 , 48 , 49 , 50 , 51 ].

Table 3 presents the results of the multivariate analysis, including only the variables that were found to be either significant or nearly significant.

A quantitative analysis of the number of fluorescent pixels showed a trend towards a higher number of functional vessels in the orthotopic tumours compared to the subcutaneous tumours ( Figure 6 c).

Age is a highly significant risk factor, and possibly the most important one, as numerous studies from around the world have demonstrated that older age is associated with a higher chance of developing a malignant breast lesion.

reported that arachnoid invasion and higher Ki-67 could be considered significant risk factors for recurrence [ 29 ].

A significant difference was found for grading of differentiation and metastatic LNs at histology, whereas borderline significance was found for histotypes.

Conventional systemic therapy with nitrosoureas and temozolomide rechallenge has limited efficacy, thus leading to an increasing trend toward precision medicine and targeted therapy for GBM.

A statistically significant correlation was set at p < 0.05; a significant trend was defined as a p < 0.1. 3.

However, the intensity of the phenomenon was marginally non-significant.

The inverse of that was found in the present study with a borderline significant increase in PDCD1LG2 [PD-L2] between st-FL and nt-FL samples, as well as an even further increase in tFL samples.

Databases from developed countries like Japan, Switzerland, Italy, or Norway have also been recently bringing data showing an increasing trend in the incidence of NENs [ 12 , 13 ].

An ECOG performance status of 2 showed a trend towards a poorer PFS but was not statistically significant (HR: 1.89, 95% CI: 0.93–3.83, and p = 0.077).

In the analysis of all-cause mortality for the different beta-lactam arm, newer publication years showed a trend favoring the combination of beta-lactam with aminoglycosides.

A decreasing trend was also reported for specific cancer types, such as colorectal cancer [ 8 , 9 , 13 ], lung cancer [ 9 , 13 ], skin melanoma [ 14 ], female breast cancer [ 9 , 13 ], prostate cancer [ 15 ], head and neck cancer [ 16 ], and pancreatic, gastric, and oesophageal cancer [ 13 ].

Trends in Cancer Stage Distribution In the national database, the analysis shows a significant trend in the distribution of cancer stages at diagnosis over time ( Figure 1 A).

Other genetic abnormalities in AML cells may be significant in the treatment of patients, for example mutations in the FMS-like tyrosine kinase-3 ( FLT3 ) gene [ 6 ].

Over the past few years, we have observed an increasing trend of publications on radiomic approaches in oncology [ 11 ], especially for predicting diagnosis [ 12 , 13 , 14 ] and treatment response [ 15 , 16 , 17 , 18 , 19 ], as well as tumor molecular profiles [ 20 , 21 ].

Statistical significance was defined as p < 0.05, with p values between 0.05 and 0.1 considered marginally significant.

In female rats, there was a positive trend in the incidence of renal tubule adenomas, which became significant in the 400 ppm 3-MCPD group [ 14 ].

As shown by our data, we found significantly reduced levels of PLK5 protein in lung, cervical, ovarian, and fallopian tube cancers, and a decreasing trend towards significance in endometrial and testicular cancer tissues ( Figure 2 B).

IMPT 1.04 ± 0.01, p < 0.001); however, no significant difference was apparent in the HI and CI of CTV.

An interesting trend in the high-ranking results was the presence of downregulated lipid droplet genes.

We achieved the highly significant identification of regulated genes across multiple cell lines either exposed or not to the same drug, and were able to accomplish this using frozen samples from lines harvested at different times.