Excerpts

In a population similar to that of our study consisting of 54 patients undergoing induction chemotherapy based on immunomodulatory drugs (IMIDs) and proteasome inhibitors (PIs), followed by ASCT, the IMAJEM study showed a trend to a significant prognostic impact of pre-transplant PET/CT on PFS [ 6 ].

Finally, one study from China indicated that the tumor content of circulating cfDNA is related to the development of HBV-related HCC and presents an increasing trend during the 4-year period preceding clinical diagnosis of HCC, whereas it is correlated with tumor burden and worse survival [ 22 ].

Taken as a whole, the identified differences in grief trajectories based on the completion of LWs in patients versus DNR orders in caregivers point to the possibility that there may be significant variation in how various forms of ACP are differentially perceived and interpreted by patients and caregivers.

The eight-year probability of overall survival was 34 ± 2% with highly significant differences according to NHL subtypes: 28 ± 3% for 254 Burkitt lymphoma/leukemia, 50 ± 6% for 98 diffuse large B-cell lymphomas, 57 ± 8% for 41 primary mediastinal large B-cell lymphomas, 27 ± 3% for 177 T-lymphoblastic lymphomas, 52 ± 10% for 34 precursor-B-cell lymphoblastic lymphomas and 30 ± 9% for 35 patients with rare NHL subtypes.

While the Kaplan–Meier survival curves still demonstrated significantly better overall survival and disease-free survival for the “T3 single” group ( Supplementary Figures S1–S3 ), the difference in cancer-specific survival became less pronounced, although the curves still showed a trend towards better survival in the “T3 single” group.

We have shown that an elevation of cell-bound CA125 is markedly significant on T cells and NK cells, and significant on B cells as well as all PBMCs together.

Kendall’s W concordance coefficient exceeded 0.85 for all measures, with corresponding p -values below 1 × 10 −12 , indicating highly significant agreement.

While age itself did not have an influence on the prognosis, PRKCA overexpression status showed a highly significant association with poor OS and DFS within the young OTSCC subgroup ( Figure 2 ).

The DOS regimen demonstrated better pathological response and showed a trend toward longer 3-year progression-free survival and 3-year overall survival, with a comparable safety profile to the SOX regimen [ 61 ].

Preliminary studies showed a trend [ 166 ] or clear evidence [ 156 , 160 ] of the prognostic value of CTC detection even in sarcoma.

We would emphasize that this observation should be interpreted with great care because the patients are few and the difference reached only borderline significance, but previous studies also suggest that ATRA therapy is less effective in patients with NPM1 wt [ 91 ].

Patients with pathogenic germline variants showed a trend toward longer PFS and OS, although this was not statistically significant ( Supplementary Figure S4 ).

Patients with high PD-L1 expression on IC showed a trend for improved survival as assessed by IC area 25% alone ( Figure 2 D; not significant in multivariable survival models) and significantly improved DSS (5-year DSS rate: 61%; HR mult = 0.44 [95%-CI = 0.27–0.72]) and DFS (5-year DFS rate: 58%; HR mult = 0.42 [95%-CI = 0.26–0.68]) as assessed by Ventana IC5% ( Figure 2 E).

This is also reflected by the borderline significance of PD-L1 expression in multi-variable adjusted survival analyses in this study [ 36 ].

Disease-Free Survival According to the Beppu and RAS-Beppu Classifications The DFS curves of the three risk groups based on the Beppu and RAS -Beppu classifications were clearly separated, and there was a significant trend for shorter DFS as the risk increased ( Figure 2 ).

While not statistically significant, increasing quartiles of methylation levels showed a trend of increased risk.

However, among men, there was a significant trend towards higher BCC risk with longer duration of statin use (P-trend = 0.003). 3.5.2.

The heritability of LINE-1 methylation may be gender-specific and there was a marginally significant inverse association between LINE-1 hypomethylation levels and increased TGCT risk [ 76 ].

Generally, all piRNAs selected for validation showed a trend of decreased quantities in TGCT patients, which was also observed in the sequencing cohort. 4.

Although the disparity in mortality may be reflected by disparities in access to care, genetics and the differential mutational burden of PCa-related genes may be significant contributing factors [ 29 ].

Nevertheless, despite no significant result, we observed a clear trend towards a better composite OS after SIB.

The simultaneous integrated boost concept showed a trend towards improving five-year composite OS compared to the sequential boost concept.

Overall, conclusions of the study do not associate tea consumption to colorectal cancer risk reduction for both genders combined, though a marginally significant inverse association may exist in women.

Radiotherapy showed a trend towards reduced risk but did not reach statistical significance (OR = 0.49, 95% CI: 0.21–1.13, p = 0.094).

In the quantitative studies, a notable trend emerged, with nine studies combining two EORTC instruments: the generic EORTC QLQ-C30 and the tumor-specific EORTC QLQ-GI.NET21, which focuses on muscle and/or bone pain, endocrine and gastrointestinal symptoms, and treatment-related effects ( Supplementary Table S2.4 ).