Excerpts

The SI of T1w, T2 w, and contrast-enhanced T1w images only showed a trend toward higher values for the treatment group ( p > 0.5, p > 0.3, and p > 0.4, respectively).

Nonetheless, our analysis suggests a possible trend towards increased recurrence in Luminal B1 tumors (37.21% in the recurrence group vs. 24.71%, p = 0.51), warranting further investigation into its clinical implications [ 27 ].

While there was a numerical trend towards OS benefit with olaparib (median OS 19.3 months versus 17.1 months), this was not statistically significant (HR 0.90; 95% CI 0.66–1.23; p = 0.513) [ 6 ].

Similarly, having fewer depressed cytokines correlated with slightly improved EFS, which approached significance for osteosarcoma ( Figure 3 C: Ewing sarcoma p = 0.52; osteosarcoma p = 0.082).

For the ROM analyses, the weighted regression test (Egger’s test) indicated mild asymmetry in the true control comparison (t(16) = −2.84, p = 0.012), while the meta-regression test did not support a significant trend ( p = 0.520) ( Supplementary Figure S1A ).

As expected and in contrast to the highly significant association between the IRFMS signature and patient outcome with ER-positive breast cancers, we did not observe a significant association (Logrank p = 0.585) between our IRFMS signature and overall survival in patients with TNBC.

A slight trend was identified between the strength loss question and the ECOG stage ( p = 0.585).

Median OS was 58 months, with a slightly non-significant positive trend in OS for patients who were non-smokers and those who did not develop G3–4 AEs ( p = 0.786 and 0.799, respectively).

Unlike the findings for TGF-beta and WNT pathway alterations, the survival analysis for the EOCRC H/L patients based on RTK/RAS pathway alterations ( Figure 1 ) indicated a possible trend toward worse survival outcomes in those with RTK/RAS mutations ( p = 0.87).

Underlying viral cirrhosis ( p = 0.033), A6 or higher pre-SBRT Child–Pugh score ( p = 0.010), and pre-SBRT platelet count <100,000/mm 3 ( p = 0.017) were significant for a rise in Child–Pugh score of 2 points or more, and the volume of liver-GTV <1000 cm 3 ( p = 0.093) approached significance.

A comparison of the Beta values representing methylation levels of all probes showed an overall trend of hypomethylation in DLBCL compared to control cases ( Figure 2 B), suggesting global methylation associated with DLBCL pathogenesis.

IM-type DR and the presence of lymph node metastasis showed a trend toward poorer OS, although they were not statistically significant in the multivariate model (HR: 1.744, p = 0.387; and HR: 2.057, p = 0.172, respectively). 4.

These findings, although partially significant, may suggest that a clear and consistent association between UC recovery and preoperative MRI parameters is still elusive.

As shown in Supplementary Figure S1C,D , no significant differences were observed between groups in the prevalence of infections by HHV, HPV, and β-HPV, whereas low-risk individuals showed a trend toward a higher frequency of HPyV infections.

Importantly, patients who underwent surgery after CROSS showed a trend toward improved OS compared with those who did not (44.1 vs. 19.6 months), reaffirming the critical role of surgery in achieving durable outcomes in this complex disease setting.

Among lower-grade gliomas (WHO grades 2–3), IDH-mutant tumors showed a trend toward decreased fluorescence (48.6% vs. 80.0%), although this did not reach statistical significance ( p = 0.08).

As a result, only genes with highly significant and large differential changes in expression among all datasets were retained in the analysis.

Primary Endpoint: Total Radiation Dose The primary analysis revealed highly significant differences in total radiation exposure among techniques ( Figure 4 ).

The estimated incidence of AC in the United States is approximately 6 cases per 1,000,000 individuals annually, with an increasing trend observed over the past two decades [ 3 , 4 , 5 , 6 ].

Thirdly, highly significant statistical heterogeneities were observed across the estimations.

Other comorbid conditions such as peripheral artery disease, high New York Heart Association (NYHA) functional class, and chronic renal and pulmonary disease are also highly significant, albeit with a lower odds ratio.

A clear trend emerges: multimodal and weakly supervised approaches, integration of peritumoral regions, and temporal modeling are showing promise across multiple clinical targets.

Baseline body weight and estimated glomerular filtration rate at cycle 1 (GFR_C1) demonstrated borderline associations with AKD ( p = 0.06 for both), implying a possible trend toward higher risk in patients with greater body mass or lower baseline kidney function reserve.

Three-year OS was 34%, 29%, and 41% in the three groups, respectively, with a nonsignificant trend towards better OS for patients with relapsed AML and a peak 3-year OS of 51% in patients transplanted with leukemic BM infiltration <20%.

Observational studies showed a significantly reduced risk of rebleeding with anticoagulation (OR 0.15, 95% CI 0.04–0.52), while randomized controlled trials demonstrated a nonsignificant trend in the same direction (OR 0.84, 95% CI 0.31–2.32) [ 115 ].