Excerpts

Malignant nodules, regardless of TERT status, showed a trend toward higher RAS AF than benign nodules (23.0% vs. 16.3%; p = 0.052).

In survival analyses we observed that high basal levels of IL-6 (over 6.0 pg/mL) were significantly associated with lower OS ( p = 0.029) and were almost significantly associated with lower PFS ( p = 0.052) ( Figure 5 C,D).

The 5-gene risk score calculated as PC1 was associated with the partial significance of worse prognosis (HR: 1.27, 95% CI: 1.0–1.61, p -value = 0.052), and the low-risk group was partially associated with better disease prognosis (HR: 0.72, 95% CI: 0.51–1.03, p -value = 0.073), as shown in Figure 2 A. 3.3.

A notable trend in differences in iPGV prevalence between patients identifying as Hispanic/Latinx and those identifying as Ashkenazi Jewish ( p = 0.052) was detected.

In the multivariate model, the presence of SARIFA showed a trend toward significance in its association with lymph node involvement (OR = 4.886; 95% CI: 0.985–24.241; p = 0.052).

DSS showed nearly significant difference ( p = 0.052): the 5-year disease-specific survival rate of SLN-negative cases was 92.7%, while that of SLN-positive cases was 77.5%.

In the T2CTC dataset ( Figure 8 ), a baseline effect of Trop2 expression was found for the bone metastatic condition ( p = 0.04255), with a marginally significant difference in slope between those with bone metastasis and without ( p = 0.052).

Compared to non-DCB patients, patients who exhibited DCB showed a trend towards increased Jaccard similarity, i.e., greater proportion of shared CDR3 sequences between PRE and FR samples ( p = 0.052; Figure S7 and Table S5 ).

The k PL showed borderline significance in predicting the variance in tumor MCT1 expression at the biopsy level ( p = 0.052; Supplementary Figure S8 ) and was independent of the cell density in tumor biopsies ( p = 0.95, Supplementary Figure S7 ).

However, as shown in Supplementary Figure S3B , a possible trend toward significance showing an association between SETDB1 expression and NSCLC patients carrying mutations for the TP53 gene was observed (SMD: 0.15; 95% CI: −0.004–0.31; p = 0.052), with low heterogeneity ( I 2 = 0%; p = 0.60).

After multivariate analysis, only combined nodal status and preoperative CEA ( p = 0.033), no postoperative s-CT ( p = 0.001), positive margins ( p = 0.008), and, with borderline significance, age ( p = 0.052) were independently associated with PM. 4.

The univariate analysis also reveals a trend for FC to reduce the increase in financial difficulty, which is marginally significant (β = −0.18 ± 0.094, p = 0.052) ( Table 3 ).

We found this association between the FOXL2 p.C134W mutation status and FOXL2 positivity by IHC to be marginally statistically significant (mid- p -value = 0.052).

Finally, MCT1 was overexpressed in 6/10 NSCLC samples (60%); however, the difference between the tumor tissues (median = 7.07) and the adjacent tissues (median = 9.51) was marginally statistically significant ( p = 0.052) ( Figure 2 ). 3.3.

The correlation of CA125 to disease recurrence was marginally significant ( p = 0.0522) without enough statistical power to make a definitive statement about it.

Probability of OS was almost significantly higher in period V compared with period IV (1.0 vs. 0.74, p = 0.05239), and no significant differences were found in the probability of EFS and RFS between periods IV and V (0.61 ± 0.07 vs. 0.71 ± 0.1 and 0.67 ± 0.08 vs. 0.71 ± 0.12; Figure S6 ).

Moreover, for the SKOV3 cell line, CXB treatment was borderline significant compared to its control ( p -value= 0.0524) ( Figure 9 B).

Lesion Measurability and CiRT Status Lesion measurability exhibited a borderline significant association with CiRT classification ( p = 0.0525).

As the BCLC staging system is the most widely used algorithm for treatment allocation and determination of prognosis of patients with HCC [ 2 ], we also performed subgroup analyses stratified according to BCLC stage, and found a significant prognostic effect of the combined score on overall survival only in the BCLC A group, although in BCLC B and C patients, a strong trend was observed ( p = 0.053 and 0.052, respectively) ( Figure 5 c).

Unfortunately, in the initially report there was no significant difference in median overall survival of 11.2 months (95% CI 9.5–12.7) in the experimental arm versus 10.0 months (95% CI 8.3–11.0) in the placebo group; however, the p value was very close to significance at p = 0.053.

Gross total resection showed a trend toward improved survival (HR = 0.563, 95% CI: 0.315–1.007, p = 0.053), though it did not reach statistical significance. 5-ALA remained non-significant in the multivariable model (HR = 0.885, 95% CI: 0.554–1.413, p = 0.608), suggesting that while it improves resection extent, it does not independently affect survival when accounting for other clinical variables. 3.6.

Expression of MDL1 and MDL1AS in LARC Patients Predict 5-Year Survival Given the differential expression of MDL1AS between rectal cancer cells and the surrounding normal tissue ( Figure 1 A) and that the differences in levels of expression for this lncRNA were almost significant in patients with long survival when compared to those with lower survival ( p = 0.053, Table 1 ), we decided to study more deeply the connections between the expression of MDL1/MDL1AS and LARC patient survival.

One study indicated that there is a borderline significant (trend p = 0.053) in the time spent watching TV to increase the risk of breast cancer in Japanese women [ 38 ].

There were no cytokines with baseline levels associated with rPFS in Cohort 2a (Cox regression p ≥ 0.05, Figure S1c, File S1 ), although IL6 almost reached statistical significance with p = 0.053 (HR = 1.16, 95% CI = 0.998–1.34). 3.4.

When analyzing survival in all patients (stages I–IV), a borderline significance was observed (HR = 0.87, p = 0.053; median survival in the low-expression cohort = 19.4 months, median survival in the high-expression cohort = 21 months) ( Figure 1 B).