Excerpts

At this threshold, only NRAS ( p raw = 0.0021) remains statistically significant after correction ( p Bonferroni = 0.0168), whereas KRAS shows a strong trend ( p Bonferroni = 0.093).

Similar dynamics were observed for body weight: a loss was recorded by day 5, followed by a positive trend of weight gain, indicating the onset of recovery and systemic compensation.

Common Themes in HRQL with Immunotherapy Use Across the different classes of ICIs, a clear trend emerges: patients’ HRQL is better preserved while on immunotherapy than the traditional cytotoxic therapies.

The raw case numbers over the years in our data show an increasing trend, consistent with international tendencies.

Additional genes ( STK25 , PGBD4 , DIRAS3 , ATG3 , RPS6KA4 , and DDX42 ) demonstrated borderline significance, implicating pathways related to kinetochore assembly, autophagy regulation, and immune signaling.

Using a Bonferroni-corrected significance threshold ( p value of 2.7 × 10 −6 ) and a borderline significant threshold ( p value of 5.5 × 10 −5 ), seven genes showed statistically significant or borderline significant associations in at least one test: MEIKIN , STK25 , PGBD4 , DIRAS3 , ATG3 , RPS6KA4 , and DDX42 .

Patients with parietal tumors showed a trend toward greater impairment, likely due to the proximity of these lesions to the temporoparietal junction and multiple critical association fibers. 4.4.

Density also showed a trend toward significance in predicting VPI, consistent with prior reports [ 8 , 13 , 14 , 22 ], but was excluded due to its high correlation with histotype, which had a stronger association with VPI and effectively incorporated its predictive contribution.

Interestingly, an increasing trend in the use of NST was observed, reaching a peak of 64% in the 2020–2022 period, coinciding with the most recent therapeutic advancements in this setting [ 14 , 15 ].

The comparative analysis of JSCCR 2024, NCCN 2025, and ESMO 2025 underscores a clear trend toward risk-stratified, multidisciplinary management of the lateral compartment.

Anti-PD1 therapy showed a trend toward a slowed progression of cSCC and increased CD8+ expression in preliminary single-specimen analysis.

In the DIEP cohort (n = 8), a paired samples t -test revealed a highly significant improvement in abdominal well-being following reconstruction.

The prognostic value of the sFas/sFasL ratio was found to be marginally significant ( Table 3 ).

Univariate analysis showed that CBL , NRAS , KRAS , and TP53 mutations were significantly associated with inferior overall survival, while RUNX1 had borderline significance.

For rural cancer patients who already face a barrier to accessing supportive care, this impact of obesity on physical function may be significant.

Although the difference in OS between the CR group and the non-CR group did not reach statistical significance (log-rank test, p = 0.095), the CR group showed a trend toward prolonged survival (not reached vs. 8.5 months; Figure 2 B).

These findings suggest a possible trend towards more favorable histological grades in surgically treated patients; however, the small sample size precludes drawing any statistically significant conclusions ( Table 4 ). 4.

The study showed that, while there was a positive trend towards improved survival with an increasing number of lymph nodes removed for ipsilateral neck dissection, this was particularly significant for contralateral and bilateral neck dissection.

Patients with adenocarcinomas with high CXCL13 infiltration also showed a trend toward improved RFS (median survival of 52 months for the low infiltration group vs. not reached), although the results were not significant (HR: 0.3697 [95% CI: 0.1067, 1.281]) ( Figure 2 m).

Clinical response, evaluated by changes in tumor size on CT scan, showed a trend toward greater reduction in the NCRT group, although the difference was not statistically significant.

In this review, the studies measuring arsenic demonstrate slightly significant associations; this may demonstrate a lack of associations or variability in study populations.

>5 cm) ( p = 0.08), and surgical margin status ( p = 0.07) showed a trend towards statistical significance.

The model’s specificity demonstrated a decreasing trend from BI-RADS 4A to 4C subgroups ( Figure 5 , right), with the highest specificity observed in the 4A group.

High expression of HLA-DQB2 ( p = 0.046) and HLA-DPA1 ( p = 0.031) indicated a better prognosis ( Figure 7 , rows 3 and 4), though the associations were marginally significant.

VAF demonstrates a highly significant positive correlation with blast percentage, leukocyte counts, and morphological markers of dysplasia (specifically dyserythropoiesis and dysmegakaryopoiesis).